Hectd3 HECT domain E3 ubiquitin protein ligase 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hectd3provided by MGI
Official Full Name: HECT domain E3 ubiquitin protein ligase 3provided by MGI
Primary source: MGI:MGI:1923858
See related: Ensembl:ENSMUSG00000046861 AllianceGenome:MGI:1923858
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1700064K09Rik
Summary: Enables syntaxin binding activity and ubiquitin-protein transferase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Located in perinuclear region of cytoplasm. Orthologous to human HECTD3 (HECT domain E3 ubiquitin protein ligase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in duodenum adult (RPKM 36.0), small intestine adult (RPKM 35.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4; 4 D1

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (116852491..116862474)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (116995296..117005277)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The E3 ubiquitin ligase HectD3 attenuates cardiac hypertrophy and inflammation in mice.
Title: The E3 ubiquitin ligase HectD3 attenuates cardiac hypertrophy and inflammation in mice.
Deficiency of the E3 ligase gene Hectd3 remarkably increased host defense against infection by intracellular bacteria Francisella novicida, Mycobacterium, and Listeria by limiting bacterial dissemination. In the absence of HECTD3, type I IFN response was impaired during bacterial infection both in vivo and in vitro.
Title: HECTD3 mediates TRAF3 polyubiquitination and type I interferon induction during bacterial infection.
Syntaxin 8 and HECTd3 have similar subcellular localization.
Title: Interaction between syntaxin 8 and HECTd3, a HECT domain ligase.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW822000 (e-PCR)
- UniSTS:207662

AW743312 (e-PCR)
- UniSTS:207663

MARC_13905-13906:1007570719:1 (e-PCR)
- UniSTS:267602

MARC_13905-13906:1025530549:1 (e-PCR)
- UniSTS:267602

AI467540 (e-PCR)
- UniSTS:165343

Homology

Homologs of the Hectd3 gene: The Hectd3 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 450 organisms have orthologs with human gene Hectd3
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables syntaxin binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-protein transferase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables ubiquitin-protein transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: E3 ubiquitin-protein ligase HECTD3

Names: HECT domain-containing protein 3; HECT-type E3 ubiquitin transferase HECTD3; probable E3 ubiquitin-protein ligase HECTD3

NP_780453.1

EC 2.3.2.26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175244.4 → NP_780453.1 E3 ubiquitin-protein ligase HECTD3

See identical proteins and their annotated locations for NP_780453.1

Status: VALIDATED

Source sequence(s)

AL671671, BC070411

Consensus CDS

CCDS18522.1

UniProtKB/Swiss-Prot

Q3U487, Q8R1L6

UniProtKB/TrEMBL

A0A8C6H7A7

Related

ENSMUSP00000051922.10, ENSMUST00000050067.10

Conserved Domains (3) summary

cd08666
Location:238 → 371

APC10-HECTD3; APC10-like DOC1 domain of HECTD3, a HECT E3 ubiquitin ligase protein that mediates substrate ubiquitination

smart00119
Location:528 → 849

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

pfam00632
Location:586 → 845

HECT; HECT-domain (ubiquitin-transferase)