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Styxl1 serine/threonine/tyrosine interacting-like 1 [ Mus musculus (house mouse) ]

Gene ID: 76571, updated on 5-Mar-2024

Summary

Official Symbol
Styxl1provided by MGI
Official Full Name
serine/threonine/tyrosine interacting-like 1provided by MGI
Primary source
MGI:MGI:1923821
See related
Ensembl:ENSMUSG00000019178 AllianceGenome:MGI:1923821
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dusp24; Mkstyx; 1700011C14Rik
Summary
Predicted to enable protein phosphatase binding activity; protein phosphatase inhibitor activity; and pseudophosphatase activity. Predicted to be involved in several processes, including negative regulation of phosphoprotein phosphatase activity; negative regulation of stress granule assembly; and positive regulation of intrinsic apoptotic signaling pathway. Predicted to be active in mitochondrion. Orthologous to human STYXL1 (serine/threonine/tyrosine interacting like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 12.2), ovary adult (RPKM 0.7) and 1 other tissue See more
Orthologs
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Genomic context

See Styxl1 in Genome Data Viewer
Location:
5 G2; 5 75.38 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (135776074..135807277, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (135747220..135778424, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene cytochrome p450 oxidoreductase Neighboring gene 40S ribosomal protein S2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_14588 Neighboring gene STARR-positive B cell enhancer ABC_E9654 Neighboring gene transmembrane protein 120A Neighboring gene microRNA 7034 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:136254330-136254517 Neighboring gene predicted gene, 30205 Neighboring gene malate dehydrogenase 2, NAD (mitochondrial) Neighboring gene serine/arginine repetitive matrix 3 Neighboring gene STARR-positive B cell enhancer ABC_E6387

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein phosphatase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein phosphatase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein phosphatase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables pseudophosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables pseudophosphatase activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
serine/threonine/tyrosine-interacting-like protein 1
Names
dual specificity phosphatase 24 (putative)
map kinase phosphatase-like protein MK-STYX

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289554.1NP_001276483.1  serine/threonine/tyrosine-interacting-like protein 1 isoform a

    See identical proteins and their annotated locations for NP_001276483.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (a).
    Source sequence(s)
    AK005599, BC045148
    Consensus CDS
    CCDS19745.2
    UniProtKB/TrEMBL
    Q9DAR2
    Related
    ENSMUSP00000051216.5, ENSMUST00000053906.11
    Conserved Domains (1) summary
    cl28904
    Location:158311
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  2. NM_001289555.1NP_001276484.1  serine/threonine/tyrosine-interacting-like protein 1 isoform a

    See identical proteins and their annotated locations for NP_001276484.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (a).
    Source sequence(s)
    AK005599, BC045148
    Consensus CDS
    CCDS19745.2
    UniProtKB/TrEMBL
    Q9DAR2
    Related
    ENSMUSP00000106793.3, ENSMUST00000111163.9
    Conserved Domains (1) summary
    cl28904
    Location:158311
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  3. NM_001289556.1NP_001276485.1  serine/threonine/tyrosine-interacting-like protein 1 isoform c

    See identical proteins and their annotated locations for NP_001276485.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate exon and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus than isoform a.
    Source sequence(s)
    AK005858, AK161310, BC045148
    Consensus CDS
    CCDS71679.1
    UniProtKB/TrEMBL
    Q9DAG7
    Related
    ENSMUSP00000106791.3, ENSMUST00000111161.9
    Conserved Domains (1) summary
    cl28904
    Location:14167
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  4. NM_001289557.1NP_001276486.1  serine/threonine/tyrosine-interacting-like protein 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 5' UTR and lacks two alternate exons, which results in a region containing a frameshift, compared to variant 1. The encoded isoform (b) is shorter than isoform 1.
    Source sequence(s)
    AK161310, BC045148, BF471066
    Consensus CDS
    CCDS71680.1
    UniProtKB/TrEMBL
    D3YZ02
    Related
    ENSMUSP00000106792.2, ENSMUST00000111162.8
    Conserved Domains (1) summary
    cl28904
    Location:103207
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  5. NM_029659.4NP_083935.3  serine/threonine/tyrosine-interacting-like protein 1 isoform a

    See identical proteins and their annotated locations for NP_083935.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1, 2, and 3 encode the same isoform (a).
    Source sequence(s)
    AC083948, AK161310, BC045148
    Consensus CDS
    CCDS19745.2
    UniProtKB/TrEMBL
    Q9DAR2
    Related
    ENSMUSP00000106794.3, ENSMUST00000111164.9
    Conserved Domains (1) summary
    cl28904
    Location:158311
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    135776074..135807277 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254884.2XP_030110744.1  serine/threonine/tyrosine-interacting-like protein 1 isoform X6

    UniProtKB/TrEMBL
    Q9DAR2
    Related
    ENSMUSP00000135982.2, ENSMUST00000177559.8
    Conserved Domains (1) summary
    cl28904
    Location:158311
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  2. XM_030254888.2XP_030110748.1  serine/threonine/tyrosine-interacting-like protein 1 isoform X11

    UniProtKB/TrEMBL
    Q9DAG7
    Conserved Domains (1) summary
    cl28904
    Location:14167
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  3. XM_006504519.4XP_006504582.1  serine/threonine/tyrosine-interacting-like protein 1 isoform X8

    Conserved Domains (1) summary
    cl28904
    Location:119223
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  4. XM_006504511.3XP_006504574.1  serine/threonine/tyrosine-interacting-like protein 1 isoform X4

    Conserved Domains (1) summary
    cl28904
    Location:174327
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  5. XM_017321146.3XP_017176635.1  serine/threonine/tyrosine-interacting-like protein 1 isoform X5

    Conserved Domains (1) summary
    cl28904
    Location:158278
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  6. XM_017321153.3XP_017176642.1  serine/threonine/tyrosine-interacting-like protein 1 isoform X10

    Conserved Domains (1) summary
    cl28904
    Location:14134
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  7. XM_017321150.3XP_017176639.1  serine/threonine/tyrosine-interacting-like protein 1 isoform X5

    Conserved Domains (1) summary
    cl28904
    Location:158278
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  8. XM_017321149.3XP_017176638.1  serine/threonine/tyrosine-interacting-like protein 1 isoform X5

    Conserved Domains (1) summary
    cl28904
    Location:158278
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  9. XM_017321151.3XP_017176640.1  serine/threonine/tyrosine-interacting-like protein 1 isoform X5

    Conserved Domains (1) summary
    cl28904
    Location:158278
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  10. XM_017321147.3XP_017176636.1  serine/threonine/tyrosine-interacting-like protein 1 isoform X5

    Conserved Domains (1) summary
    cl28904
    Location:158278
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  11. XM_017321148.3XP_017176637.1  serine/threonine/tyrosine-interacting-like protein 1 isoform X5

    Conserved Domains (1) summary
    cl28904
    Location:158278
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  12. XM_017321145.3XP_017176634.1  serine/threonine/tyrosine-interacting-like protein 1 isoform X3

    Conserved Domains (1) summary
    cl28904
    Location:170290
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  13. XM_017321144.3XP_017176633.1  serine/threonine/tyrosine-interacting-like protein 1 isoform X2

    Conserved Domains (1) summary
    cl28904
    Location:171291
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  14. XM_017321152.2XP_017176641.1  serine/threonine/tyrosine-interacting-like protein 1 isoform X7

    Conserved Domains (1) summary
    cl28904
    Location:119190
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  15. XM_017321143.2XP_017176632.1  serine/threonine/tyrosine-interacting-like protein 1 isoform X1

    Conserved Domains (1) summary
    cl28904
    Location:174294
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
  16. XM_036165592.1XP_036021485.1  serine/threonine/tyrosine-interacting-like protein 1 isoform X9

    UniProtKB/TrEMBL
    J3QK74

RNA

  1. XR_004942585.1 RNA Sequence