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Ift46 intraflagellar transport 46 [ Mus musculus (house mouse) ]

Gene ID: 76568, updated on 12-May-2024

Summary

Official Symbol
Ift46provided by MGI
Official Full Name
intraflagellar transport 46provided by MGI
Primary source
MGI:MGI:1923818
See related
Ensembl:ENSMUSG00000002031 AllianceGenome:MGI:1923818
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
c11orf2; 1500035H01Rik
Summary
Acts upstream of or within cilium assembly and smoothened signaling pathway. Located in centrosome and motile cilium. Part of intraciliary transport particle B. Is expressed in several structures, including brain; gonad; hemolymphoid system gland; hindlimb; and otocyst. Orthologous to human IFT46 (intraflagellar transport 46). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 16.0), CNS E14 (RPKM 11.2) and 28 other tissues See more
Orthologs
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Genomic context

See Ift46 in Genome Data Viewer
Location:
9 A5.2; 9 24.84 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (44683074..44704011)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (44770456..44792714)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene pleckstrin homology like domain, family B, member 1 Neighboring gene predicted gene, 24166 Neighboring gene archain 1 Neighboring gene STARR-positive B cell enhancer ABC_E9756 Neighboring gene transmembrane protein 25 Neighboring gene tetratricopeptide repeat domain 36 Neighboring gene lysine (K)-specific methyltransferase 2A Neighboring gene predicted gene, 39326 Neighboring gene STARR-positive B cell enhancer ABC_E6728

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in ciliary base ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in ciliary membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in cilium NAS
Non-traceable Author Statement
more info
PubMed 
located_in cilium TAS
Traceable Author Statement
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
part_of intraciliary transport particle B IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of intraciliary transport particle B IDA
Inferred from Direct Assay
more info
PubMed 
part_of intraciliary transport particle B ISO
Inferred from Sequence Orthology
more info
 
is_active_in motile cilium IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in motile cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in motile cilium ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
intraflagellar transport protein 46 homolog
Names
intraflagellar transport 46 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023831.3NP_076320.2  intraflagellar transport protein 46 homolog

    See identical proteins and their annotated locations for NP_076320.2

    Status: PROVISIONAL

    Source sequence(s)
    AK032880
    Consensus CDS
    CCDS23119.1
    UniProtKB/Swiss-Prot
    Q91Z06, Q9DB07, Q9JHT1
    UniProtKB/TrEMBL
    A0A5F8MPR6
    Related
    ENSMUSP00000159011.2, ENSMUST00000239014.2
    Conserved Domains (1) summary
    pfam12317
    Location:62264
    IFT46_B_C; Intraflagellar transport complex B protein 46 C terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    44683074..44704011
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510671.5XP_006510734.1  intraflagellar transport protein 46 homolog isoform X1

    See identical proteins and their annotated locations for XP_006510734.1

    UniProtKB/Swiss-Prot
    Q91Z06, Q9DB07, Q9JHT1
    UniProtKB/TrEMBL
    A0A5F8MPR6
    Conserved Domains (1) summary
    pfam12317
    Location:62264
    IFT46_B_C; Intraflagellar transport complex B protein 46 C terminal
  2. XM_006510672.5XP_006510735.1  intraflagellar transport protein 46 homolog isoform X2

    UniProtKB/TrEMBL
    A0A1L1SR19
    Related
    ENSMUSP00000149271.3, ENSMUST00000214854.3
    Conserved Domains (1) summary
    pfam12317
    Location:62222
    IFT46_B_C; Intraflagellar transport complex B protein 46 C terminal
  3. XM_036155404.1XP_036011297.1  intraflagellar transport protein 46 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q91Z06, Q9DB07, Q9JHT1
    UniProtKB/TrEMBL
    A0A5F8MPR6
    Related
    ENSMUSP00000113845.2, ENSMUST00000118186.2
    Conserved Domains (1) summary
    pfam12317
    Location:62264
    IFT46_B_C; Intraflagellar transport complex B protein 46 C terminal

RNA

  1. XR_001779069.3 RNA Sequence