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Pcolce2 procollagen C-endopeptidase enhancer 2 [ Mus musculus (house mouse) ]

Gene ID: 76477, updated on 13-Oct-2022

Summary

Official Symbol
Pcolce2provided by MGI
Official Full Name
procollagen C-endopeptidase enhancer 2provided by MGI
Primary source
MGI:MGI:1923727
See related
Ensembl:ENSMUSG00000015354 AllianceGenome:MGI:1923727
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pcpe2; 2400001O18Rik
Summary
Predicted to enable collagen binding activity; heparin binding activity; and peptidase activator activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Located in collagen-containing extracellular matrix. Is expressed in several structures, including branchial arch; jaw; limb; nasal cavity epithelium; and skeleton. Orthologous to human PCOLCE2 (procollagen C-endopeptidase enhancer 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lung adult (RPKM 28.4), liver E18 (RPKM 4.2) and 5 other tissues See more
Orthologs
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Genomic context

See Pcolce2 in Genome Data Viewer
Location:
9; 9 E3.3
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (95519681..95577604)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (95637628..95695551)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32542 Neighboring gene predicted gene 16126 Neighboring gene predicted gene, 25582 Neighboring gene inosine triphosphatase (nucleoside triphosphate pyrophosphatase) pseudogene 2 Neighboring gene predicted gene, 39407 Neighboring gene transient receptor potential cation channel, subfamily C, member 1 Neighboring gene plastin 1 (I-isoform) Neighboring gene VISTA enhancer mm1367

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables collagen binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables collagen binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
enables heparin binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables peptidase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables peptidase activator activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
PubMed 

General protein information

Preferred Names
procollagen C-endopeptidase enhancer 2
Names
PCPE-2
procollagen C-proteinase enhancer 2
procollagen COOH-terminal proteinase enhancer 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029620.2NP_083896.1  procollagen C-endopeptidase enhancer 2 precursor

    See identical proteins and their annotated locations for NP_083896.1

    Status: VALIDATED

    Source sequence(s)
    AK010249, AK132395
    Consensus CDS
    CCDS23410.1
    UniProtKB/Swiss-Prot
    Q8R4W6, Q9CX06
    Related
    ENSMUSP00000015498.9, ENSMUST00000015498.9
    Conserved Domains (3) summary
    cd00041
    Location:32142
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd03576
    Location:291414
    NTR_PCOLCE; NTR domain, PCOLCE subfamily; Procollagen C-endopeptidase enhancers (PCOLCEs) are extracellular matrix proteins that enhance the activity of procollagen C-proteases, by binding to the procollagen I C-peptide. They contain a C-terminal NTR domain, which ...
    pfam00431
    Location:153264
    CUB; CUB domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    95519681..95577604
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)