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Car12 carbonic anhydrase 12 [ Mus musculus (house mouse) ]

Gene ID: 76459, updated on 28-Aug-2018

Summary

Official Symbol
Car12provided by MGI
Official Full Name
carbonic anhydrase 12provided by MGI
Primary source
MGI:MGI:1923709
See related
Ensembl:ENSMUSG00000032373 Vega:OTTMUSG00000025353
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ca12; CA-XII; AI314958; 2310047E01Rik
Summary
This gene encodes a membrane-bound member of the alpha carbonic anhydrase family of enzymes that catalyze the reversible hydration of carbon dioxide to bicarbonate. These proteins participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Expression
Biased expression in kidney adult (RPKM 57.2), limb E14.5 (RPKM 7.3) and 5 other tissues See more
Orthologs

Genomic context

See Car12 in Genome Data Viewer
Location:
9; 9 C
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (66711626..66766845)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (66561493..66614652)

Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 Neighboring gene F-box and leucine-rich repeat protein 22 Neighboring gene ubiquitin specific peptidase 3 Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 2, pseudogene 4 Neighboring gene aph1 homolog B, gamma secretase subunit

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
carbonate dehydratase activity IDA
Inferred from Direct Assay
more info
PubMed 
lyase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
carbon dioxide transport IC
Inferred by Curator
more info
PubMed 
chloride ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
regulation of pH IC
Inferred by Curator
more info
PubMed 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
carbonic anhydrase 12
Names
CA XII
carbonate dehydratase XII
carbonic anhydrase XII
NP_001293077.1
NP_848483.3
XP_006511611.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001306148.1NP_001293077.1  carbonic anhydrase 12 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001293077.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC134429, AI414285, AK009873, AK052639, BU700194, BX513273, BY236613, CX240181
    Consensus CDS
    CCDS81026.1
    UniProtKB/Swiss-Prot
    Q8CI85
    UniProtKB/TrEMBL
    Q8K2J1
    Related
    ENSMUSP00000082541.5, OTTMUSP00000030758, ENSMUST00000085420.11, OTTMUST00000062412
    Conserved Domains (1) summary
    cl00012
    Location:39290
    alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
  2. NM_178396.5NP_848483.3  carbonic anhydrase 12 isoform 1 precursor

    See identical proteins and their annotated locations for NP_848483.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC134429, AI414285, AK009873, AK052639, BU700194, BX513273, BY236613, CX240181
    Consensus CDS
    CCDS23306.1
    UniProtKB/Swiss-Prot
    Q8CI85
    UniProtKB/TrEMBL
    A0A0R4J0W4
    Related
    ENSMUSP00000071786.6, OTTMUSP00000030757, ENSMUST00000071889.12, OTTMUST00000062411
    Conserved Domains (1) summary
    cl00012
    Location:39290
    alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

    Range
    66711626..66766845
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511548.3XP_006511611.1  carbonic anhydrase 12 isoform X1

    Conserved Domains (1) summary
    cl00012
    Location:39290
    alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
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