Rftn1 raftlin lipid raft linker 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rftn1provided by MGI
Official Full Name: raftlin lipid raft linker 1provided by MGI
Primary source: MGI:MGI:1923688
See related: Ensembl:ENSMUSG00000039316 AllianceGenome:MGI:1923688
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2310015N21Rik
Summary: Predicted to enable double-stranded RNA binding activity. Involved in several processes, including T cell antigen processing and presentation; T cell receptor signaling pathway; and positive regulation of interleukin-17 production. Predicted to be located in endosome; membrane raft; and plasma membrane. Predicted to be part of protein-containing complex. Is expressed in brain and dorsal grey horn. Orthologous to human RFTN1 (raftlin, lipid raft linker 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in spleen adult (RPKM 21.3), thymus adult (RPKM 21.0) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17; 17 C

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (50300287..50497525, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (49993258..50190497, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

this study shows that raftlin appears to modulate cargo selection as an accessary protein of clathrin-associated adaptor protein-2 in clathrin-mediated endocytosis of TLR3/4 ligands
Title: Raftlin Controls Lipopolysaccharide-Induced TLR4 Internalization and TICAM-1 Signaling in a Cell Type-Specific Manner.
Raftlin cooperates with the uptake receptor to mediate cell entry of poly(I:C), which is critical for activation of TLR3.
Title: Raftlin is involved in the nucleocapture complex to induce poly(I:C)-mediated TLR3 activation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU048992 (e-PCR)
- UniSTS:145440

PrC117 (e-PCR)
- UniSTS:532094

AI853526 (e-PCR)
- UniSTS:166063

D17Mit117 (e-PCR), detects polymorphism
- UniSTS:127952

Homology

Homologs of the Rftn1 gene: The Rftn1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, rat, chicken, and frog.
Orthologs from Annotation Pipeline: 351 organisms have orthologs with human gene Rftn1
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables double-stranded RNA binding	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in B cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in T cell antigen processing and presentation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in T cell receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dsRNA transport	ISO Inferred from Sequence Orthology more info	PubMed
involved_in membrane raft assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of growth rate	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-17 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to membrane raft	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport into membrane raft	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to exogenous dsRNA	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within toll-like receptor 3 signaling pathway	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info	PubMed
located_in endosome	ISO Inferred from Sequence Orthology more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: raftlin

Names: raft-linking protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.