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Gid8 GID complex subunit 8 [ Mus musculus (house mouse) ]

Gene ID: 76425, updated on 8-Jan-2023

Summary

Official Symbol
Gid8provided by MGI
Official Full Name
GID complex subunit 8provided by MGI
Primary source
MGI:MGI:1923675
See related
Ensembl:ENSMUSG00000027573 AllianceGenome:MGI:1923675
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Twa1; 2310003C23Rik; 4833420G11Rik
Summary
Enables protein homodimerization activity. Predicted to be involved in positive regulation of canonical Wnt signaling pathway; positive regulation of cell population proliferation; and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within Wnt signaling pathway. Predicted to be located in cell junction; cytosol; and nucleoplasm. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human GID8 (GID complex subunit 8 homolog). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 23.4), liver E14.5 (RPKM 22.0) and 28 other tissues See more
Orthologs
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Genomic context

See Gid8 in Genome Data Viewer
Location:
2; 2 H4
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (180351874..180363392)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (180710122..180721599)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene transcription factor-like 5 (basic helix-loop-helix) Neighboring gene predicted gene, 54097 Neighboring gene death inducer-obliterator 1 Neighboring gene predicted gene, 22502 Neighboring gene predicted gene, 30455 Neighboring gene solute carrier family 17, member 9 Neighboring gene basic helix-loop-helix family, member e23

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • RP24-209P15.2

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cell junction ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
glucose-induced degradation protein 8 homolog
Names
GID complex subunit 8 homolog
protein C20orf11 homolog
two hybrid-associated protein 1 with RanBPM

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289651.1NP_001276580.1  glucose-induced degradation protein 8 homolog

    See identical proteins and their annotated locations for NP_001276580.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK009106, AL732560
    Consensus CDS
    CCDS17185.1
    UniProtKB/Swiss-Prot
    Q9D7M1
    UniProtKB/TrEMBL
    A0A6P5P8H1, A0A8C6HEY6
    Conserved Domains (2) summary
    pfam08513
    Location:2852
    LisH
    pfam10607
    Location:63207
    CLTH; CTLH/CRA C-terminal to LisH motif domain
  2. NM_001289652.1NP_001276581.1  glucose-induced degradation protein 8 homolog

    See identical proteins and their annotated locations for NP_001276581.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK009106, AL732560, BY131338
    Consensus CDS
    CCDS17185.1
    UniProtKB/Swiss-Prot
    Q9D7M1
    UniProtKB/TrEMBL
    A0A6P5P8H1, A0A8C6HEY6
    Related
    ENSMUSP00000029090.3, ENSMUST00000029090.9
    Conserved Domains (2) summary
    pfam08513
    Location:2852
    LisH
    pfam10607
    Location:63207
    CLTH; CTLH/CRA C-terminal to LisH motif domain
  3. NM_029607.2NP_083883.1  glucose-induced degradation protein 8 homolog

    See identical proteins and their annotated locations for NP_083883.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK009106, AL732560, BC059022
    Consensus CDS
    CCDS17185.1
    UniProtKB/Swiss-Prot
    Q9D7M1
    UniProtKB/TrEMBL
    A0A6P5P8H1, A0A8C6HEY6
    Related
    ENSMUSP00000077753.6, ENSMUST00000078687.6
    Conserved Domains (2) summary
    pfam08513
    Location:2852
    LisH
    pfam10607
    Location:63207
    CLTH; CTLH/CRA C-terminal to LisH motif domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    180351874..180363392
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162670.1XP_036018563.1  glucose-induced degradation protein 8 homolog isoform X2

    Conserved Domains (2) summary
    pfam08513
    Location:2852
    LisH
    pfam10607
    Location:63171
    CLTH; CTLH/CRA C-terminal to LisH motif domain
  2. XM_030252191.2XP_030108051.1  glucose-induced degradation protein 8 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q9D7M1
    UniProtKB/TrEMBL
    A0A6P5P8H1, A0A8C6HEY6
    Conserved Domains (2) summary
    pfam08513
    Location:2852
    LisH
    pfam10607
    Location:63207
    CLTH; CTLH/CRA C-terminal to LisH motif domain
  3. XM_036162669.1XP_036018562.1  glucose-induced degradation protein 8 homolog isoform X1

    UniProtKB/Swiss-Prot
    Q9D7M1
    UniProtKB/TrEMBL
    A0A6P5P8H1, A0A8C6HEY6
    Conserved Domains (2) summary
    pfam08513
    Location:2852
    LisH
    pfam10607
    Location:63207
    CLTH; CTLH/CRA C-terminal to LisH motif domain