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ZNF221 zinc finger protein 221 [ Homo sapiens (human) ]

Gene ID: 7638, updated on 13-May-2022

Summary

Official Symbol
ZNF221provided by HGNC
Official Full Name
zinc finger protein 221provided by HGNC
Primary source
HGNC:HGNC:13014
See related
Ensembl:ENSG00000159905 AllianceGenome:HGNC:13014
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary (RPKM 1.3), brain (RPKM 1.3) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF221 in Genome Data Viewer
Location:
19q13.31
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (43951228..43981613)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (46774167..46790633)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (44455380..44471861)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100505715 Neighboring gene ZNF45 antisense RNA 1 Neighboring gene zinc finger protein 45 Neighboring gene zinc finger protein 155 Neighboring gene ZNF230 divergent transcript Neighboring gene zinc finger protein 230

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC138186, MGC141986

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001297588.2NP_001284517.1  zinc finger protein 221

    See identical proteins and their annotated locations for NP_001284517.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC006213, AF187987, AK314207, DA493401, KF459580
    Consensus CDS
    CCDS12633.1
    UniProtKB/Swiss-Prot
    Q9UK13
    UniProtKB/TrEMBL
    A0A087WT08
    Related
    ENSP00000467367.1, ENST00000587682.6
    Conserved Domains (3) summary
    COG5048
    Location:166576
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:228248
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:3070
    KRAB; KRAB box
  2. NM_001297589.2NP_001284518.1  zinc finger protein 221

    See identical proteins and their annotated locations for NP_001284518.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC006213, BP337374, KF459580
    Consensus CDS
    CCDS12633.1
    UniProtKB/TrEMBL
    A0A087WT08
    Conserved Domains (3) summary
    COG5048
    Location:166576
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:228248
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:3070
    KRAB; KRAB box
  3. NM_013359.3NP_037491.2  zinc finger protein 221

    See identical proteins and their annotated locations for NP_037491.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AC006213, AF187987, BC111981
    Consensus CDS
    CCDS12633.1
    UniProtKB/Swiss-Prot
    Q9UK13
    UniProtKB/TrEMBL
    A0A087WT08
    Related
    ENSP00000251269.4, ENST00000251269.9
    Conserved Domains (3) summary
    COG5048
    Location:166576
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:228248
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:3070
    KRAB; KRAB box

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    43951228..43981613
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047439352.1XP_047295308.1  zinc finger protein 221 isoform X1

RNA

  1. XR_007066976.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    46774167..46790633
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)