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CA5A carbonic anhydrase 5A [ Homo sapiens (human) ]

Gene ID: 763, updated on 3-Jun-2018
Official Symbol
CA5Aprovided by HGNC
Official Full Name
carbonic anhydrase 5Aprovided by HGNC
Primary source
HGNC:HGNC:1377
See related
Ensembl:ENSG00000174990 MIM:114761; Vega:OTTHUMG00000137677
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CA5; CAV; CAVA; CA5AD; GS1-21A4.1
Summary
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA VA is localized in the mitochondria and expressed primarily in the liver. It may play an important role in ureagenesis and gluconeogenesis. CA5A gene maps to chromosome 16q24.3 and an unprocessed pseudogene has been assigned to 16p12-p11.2. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward liver (RPKM 2.8) See more
Orthologs
See CA5A in Genome Data Viewer
Location:
16q24.2
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (87888013..87936575, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (87921625..87970173, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene solute carrier family 7 member 5 Neighboring gene microRNA 6775 Neighboring gene uncharacterized LOC107987237 Neighboring gene small EDRK-rich factor 1 pseudogene Neighboring gene BTG3 associated nuclear protein

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Tat tat FITC-labeled Tat 47-59 peptide downregulates gene expression of carbonic anhydrase VA, mitochondrial (CA5A) in U-937 macrophages PubMed

Go to the HIV-1, Human Interaction Database

  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Nitrogen metabolism, organism-specific biosystem (from KEGG)
    Nitrogen metabolism, organism-specific biosystemThe biological process of the nitrogen cycle is a complex interplay among many microorganisms catalyzing different reactions, where nitrogen is found in various oxidation states ranging from +5 in ni...
  • Nitrogen metabolism, conserved biosystem (from KEGG)
    Nitrogen metabolism, conserved biosystemThe biological process of the nitrogen cycle is a complex interplay among many microorganisms catalyzing different reactions, where nitrogen is found in various oxidation states ranging from +5 in ni...
  • Reversible hydration of carbon dioxide, organism-specific biosystem (from REACTOME)
    Reversible hydration of carbon dioxide, organism-specific biosystemCarbonic anhydrases reversibly catalyze the hydration of carbon dioxide and directly produce bicarbonate and protons, bypassing the formation of carbonic acid (reviewed in Lindskog 1997, Breton 2001,...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carbonate dehydratase activity TAS
Traceable Author Statement
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
bicarbonate transport TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
mitochondrial matrix TAS
Traceable Author Statement
more info
 
mitochondrion TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
carbonic anhydrase 5A, mitochondrial
Names
CA-VA
carbonate dehydratase VA
carbonic anhydrase V, mitochondrial
carbonic anhydrase VA, mitochondrial
carbonic dehydratase
NP_001730.1
XP_005256191.1
XP_011521611.1
XP_016879135.1
XP_024306202.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033227.1 RefSeqGene

    Range
    5001..53488
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001739.1NP_001730.1  carbonic anhydrase 5A, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001730.1

    Status: REVIEWED

    Source sequence(s)
    U25134
    Consensus CDS
    CCDS10965.1
    UniProtKB/Swiss-Prot
    P35218
    Related
    ENSP00000309649.2, OTTHUMP00000175040, ENST00000309893.3, OTTHUMT00000269164
    Conserved Domains (1) summary
    cd03118
    Location:61296
    alpha_CA_V; Carbonic anhydrase alpha, CA isozyme V_like subgroup. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    87888013..87936575 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450434.1XP_024306202.1  carbonic anhydrase 5A, mitochondrial isoform X4

    Conserved Domains (1) summary
    cl00012
    Location:27170
    alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
  2. XM_017023646.1XP_016879135.1  carbonic anhydrase 5A, mitochondrial isoform X2

  3. XM_011523309.2XP_011521611.1  carbonic anhydrase 5A, mitochondrial isoform X1

    Conserved Domains (1) summary
    cl00012
    Location:61212
    alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
  4. XM_005256134.4XP_005256191.1  carbonic anhydrase 5A, mitochondrial isoform X3

    Conserved Domains (1) summary
    cl00012
    Location:61114
    alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

RNA

  1. XR_002957839.1 RNA Sequence

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