Format

Send to:

Choose Destination

CA5A carbonic anhydrase 5A [ Homo sapiens (human) ]

Gene ID: 763, updated on 11-Jun-2021

Summary

Official Symbol
CA5Aprovided by HGNC
Official Full Name
carbonic anhydrase 5Aprovided by HGNC
Primary source
HGNC:HGNC:1377
See related
Ensembl:ENSG00000174990 MIM:114761
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CA5; CAV; CAVA; CA5AD; GS1-21A4.1
Summary
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA VA is localized in the mitochondria and expressed primarily in the liver. It may play an important role in ureagenesis and gluconeogenesis. CA5A gene maps to chromosome 16q24.3 and an unprocessed pseudogene has been assigned to 16p12-p11.2. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward liver (RPKM 2.8) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See CA5A in Genome Data Viewer
Location:
16q24.2
Exon count:
11
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (87881549..87936575, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (87915155..87970135, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene solute carrier family 7 member 5 Neighboring gene uncharacterized LOC107987237 Neighboring gene CRISPRi-validated cis-regulatory element chr16.4806 Neighboring gene small EDRK-rich factor 1 pseudogene Neighboring gene BTG3 associated nuclear protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat FITC-labeled Tat 47-59 peptide downregulates gene expression of carbonic anhydrase VA, mitochondrial (CA5A) in U-937 macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carbonate dehydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables hydro-lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in bicarbonate transport TAS
Traceable Author Statement
more info
 
involved_in one-carbon metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrial matrix TAS
Traceable Author Statement
more info
 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
carbonic anhydrase 5A, mitochondrial
Names
CA-VA
carbonate dehydratase VA
carbonic anhydrase V, mitochondrial
carbonic anhydrase VA, mitochondrial
carbonic dehydratase
NP_001354154.1
NP_001730.1
XP_005256191.1
XP_011521611.1
XP_016879135.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033227.2 RefSeqGene

    Range
    5001..53517
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1280

mRNA and Protein(s)

  1. NM_001367225.1NP_001354154.1  carbonic anhydrase 5A, mitochondrial isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' structure, resulting in a novel 3' coding region, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC127455, AC133539
    Related
    ENSP00000496993.1, ENST00000649158.1
    Conserved Domains (1) summary
    cl00012
    Location:61258
    alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
  2. NM_001739.2NP_001730.1  carbonic anhydrase 5A, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_001730.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC133539, BJ996241, L19297
    Consensus CDS
    CCDS10965.1
    UniProtKB/Swiss-Prot
    P35218
    Related
    ENSP00000498065.2, ENST00000649794.3
    Conserved Domains (1) summary
    cd03118
    Location:61296
    alpha_CA_V; Carbonic anhydrase alpha, CA isozyme V_like subgroup. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

RNA

  1. NR_159798.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC127455, AC133539
    Related
    ENST00000648022.1
  2. NR_159799.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC127455, AC133539

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    87881549..87936575 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017023646.1XP_016879135.1  carbonic anhydrase 5A, mitochondrial isoform X2

  2. XM_011523309.2XP_011521611.1  carbonic anhydrase 5A, mitochondrial isoform X1

    Conserved Domains (1) summary
    cl00012
    Location:61212
    alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
  3. XM_005256134.4XP_005256191.1  carbonic anhydrase 5A, mitochondrial isoform X3

    Conserved Domains (1) summary
    cl00012
    Location:61114
    alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
Support Center