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Atp11b ATPase, class VI, type 11B [ Mus musculus (house mouse) ]

Gene ID: 76295, updated on 8-Dec-2022

Summary

Official Symbol
Atp11bprovided by MGI
Official Full Name
ATPase, class VI, type 11Bprovided by MGI
Primary source
MGI:MGI:1923545
See related
Ensembl:ENSMUSG00000037400 AllianceGenome:MGI:1923545
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ATPIF; ATPIR; mKIAA0956; 1110019I14Rik
Summary
Predicted to enable ATPase-coupled intramembrane lipid transporter activity. Predicted to be involved in phospholipid translocation. Predicted to act upstream of or within lipid transport. Predicted to be located in Golgi apparatus; endosome; and membrane. Predicted to be integral component of membrane. Predicted to be active in several cellular components, including endoplasmic reticulum; recycling endosome; and trans-Golgi network. Is expressed in 2-cell stage embryo and 4-cell stage embryo. Orthologous to human ATP11B (ATPase phospholipid transporting 11B (putative)). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in frontal lobe adult (RPKM 18.5), CNS E18 (RPKM 15.8) and 28 other tissues See more
Orthologs
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Genomic context

See Atp11b in Genome Data Viewer
Location:
3; 3 B
Exon count:
35
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (35808104..35910425)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (35754044..35856276)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene 6639 Neighboring gene predicted gene, 25696 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene chaperonin containing Tcp1, subunit 8 (theta) pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (3) 

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables ATPase-coupled intramembrane lipid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables transporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in aminophospholipid transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lipid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in phospholipid translocation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phospholipid transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
part_of phospholipid-translocating ATPase complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in recycling endosome ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
phospholipid-transporting ATPase IF; probable phospholipid-transporting ATPase IF
Names
P4-ATPase flippase complex alpha subunit ATP11B
NP_083846.2
XP_006535637.1
XP_030108731.1
XP_030108733.1
XP_036019283.1
XP_036019284.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029570.4NP_083846.2  phospholipid-transporting ATPase IF

    See identical proteins and their annotated locations for NP_083846.2

    Status: VALIDATED

    Source sequence(s)
    BC076603, CF952078, CJ128477, CN535194
    Consensus CDS
    CCDS38414.1
    UniProtKB/Swiss-Prot
    Q6DFW5
    UniProtKB/TrEMBL
    Q6DFW5
    Related
    ENSMUSP00000029257.9, ENSMUST00000029257.15
    Conserved Domains (1) summary
    cd02073
    Location:41978
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C

RNA

  1. NR_151626.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC157780, BC076603
  2. NR_151627.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC157780, BC076603

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    35808104..35910425
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163391.1XP_036019284.1  probable phospholipid-transporting ATPase IF isoform X4

    Conserved Domains (1) summary
    cl21460
    Location:13590
    HAD_like; Haloacid Dehalogenase-like Hydrolases
  2. XM_036163390.1XP_036019283.1  probable phospholipid-transporting ATPase IF isoform X1

    Related
    ENSMUSP00000142676.2, ENSMUST00000198599.2
    Conserved Domains (1) summary
    cd02073
    Location:41978
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
  3. XM_006535574.4XP_006535637.1  probable phospholipid-transporting ATPase IF isoform X3

    Related
    ENSMUST00000200445.5
    Conserved Domains (1) summary
    cd02073
    Location:41835
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
  4. XM_030252871.1XP_030108731.1  probable phospholipid-transporting ATPase IF isoform X2

    Conserved Domains (2) summary
    cd02073
    Location:1715
    P-type_ATPase_APLT_Dnf-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C
    cl28910
    Location:654800
    MFS; Major Facilitator Superfamily
  5. XM_030252873.1XP_030108733.1  probable phospholipid-transporting ATPase IF isoform X4

    Conserved Domains (1) summary
    cl21460
    Location:13590
    HAD_like; Haloacid Dehalogenase-like Hydrolases