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Gpt glutamic pyruvic transaminase, soluble [ Mus musculus (house mouse) ]

Gene ID: 76282, updated on 5-Mar-2024

Summary

Official Symbol
Gptprovided by MGI
Official Full Name
glutamic pyruvic transaminase, solubleprovided by MGI
Primary source
MGI:MGI:95802
See related
Ensembl:ENSMUSG00000022546 AllianceGenome:MGI:95802
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ALT; ALT1; Gpt1; Gpt-1; 1300007J06Rik; 2310022B03Rik
Summary
Predicted to enable L-alanine:2-oxoglutarate aminotransferase activity and pyridoxal phosphate binding activity. Predicted to be involved in positive regulation of gluconeogenesis. Located in extracellular space. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human GPT (glutamic--pyruvic transaminase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 148.9), duodenum adult (RPKM 136.1) and 12 other tissues See more
Orthologs
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Genomic context

See Gpt in Genome Data Viewer
Location:
15 D3; 15 36.28 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (76580926..76583875)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (76696726..76699675)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene kinesin family member C2 Neighboring gene STARR-positive B cell enhancer ABC_E5491 Neighboring gene forkhead box H1 Neighboring gene protein phosphatase 1, regulatory subunit 16A Neighboring gene STARR-seq mESC enhancer starr_39060 Neighboring gene major facilitator superfamily domain containing 3 Neighboring gene RecQ protein-like 4 Neighboring gene STARR-positive B cell enhancer ABC_E7385 Neighboring gene leucine rich repeat containing 14

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • 1300007J06Rik, 2310022B03Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-alanine:2-oxoglutarate aminotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables L-alanine:2-oxoglutarate aminotransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
 
enables transaminase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of gluconeogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
alanine aminotransferase 1
Names
GPT 1
glutamate pyruvate transaminase 1
glutamic pyruvic transaminase 1, soluble
glutamic--alanine transaminase 1
glutamic--pyruvic transaminase 1
NP_877957.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_182805.3NP_877957.1  alanine aminotransferase 1

    See identical proteins and their annotated locations for NP_877957.1

    Status: VALIDATED

    Source sequence(s)
    AC156550, AI196515, AK009457, BU706045
    Consensus CDS
    CCDS27586.1
    UniProtKB/Swiss-Prot
    Q8QZR5
    UniProtKB/TrEMBL
    Q566C3
    Related
    ENSMUSP00000023203.5, ENSMUST00000023203.6
    Conserved Domains (2) summary
    cd00609
    Location:98485
    AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
    PTZ00377
    Location:19496
    PTZ00377; alanine aminotransferase; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    76580926..76583875
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)