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ZNF75A zinc finger protein 75a [ Homo sapiens (human) ]

Gene ID: 7627, updated on 5-Jan-2022

Summary

Official Symbol
ZNF75Aprovided by HGNC
Official Full Name
zinc finger protein 75aprovided by HGNC
Primary source
HGNC:HGNC:13146
See related
Ensembl:ENSG00000162086 MIM:601473
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in lymph node (RPKM 3.9), testis (RPKM 3.7) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF75A in Genome Data Viewer
Location:
16p13.3
Exon count:
10
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (3305478..3322999)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (3355497..3368851)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 921 Neighboring gene zinc finger protein 263 Neighboring gene tigger transposable element derived 7 Neighboring gene ribosomal protein L7 like 1 pseudogene Neighboring gene olfactory receptor family 2 subfamily C member 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ31529, MGC59959

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302109.2NP_001289038.1  zinc finger protein 75A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC004232, AC025283, BC119652, BX324672, CR749782, DB249528
    UniProtKB/Swiss-Prot
    Q96N20
    UniProtKB/TrEMBL
    Q68CU0
    Related
    ENSP00000499415.1, ENST00000669516.2
    Conserved Domains (8) summary
    smart00431
    Location:50153
    SCAN; leucine rich region
    smart00349
    Location:235296
    KRAB; krueppel associated box
    COG5048
    Location:400537
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:432452
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:486508
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:235274
    KRAB; KRAB box
    pfam02023
    Location:44132
    SCAN; SCAN domain
    pfam13465
    Location:416439
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001324041.1NP_001310970.1  zinc finger protein 75A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC004232, AC025283
    Conserved Domains (8) summary
    smart00431
    Location:50153
    SCAN; leucine rich region
    smart00349
    Location:235296
    KRAB; krueppel associated box
    COG5048
    Location:400537
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:432452
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:486508
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:235274
    KRAB; KRAB box
    pfam02023
    Location:44132
    SCAN; SCAN domain
    pfam13465
    Location:416439
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001324085.2NP_001311014.1  zinc finger protein 75A isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC004232, AC025283
    Related
    ENSP00000499242.1, ENST00000498240.6
    Conserved Domains (2) summary
    smart00431
    Location:50153
    SCAN; leucine rich region
    pfam02023
    Location:44132
    SCAN; SCAN domain
  4. NM_001352495.2NP_001339424.1  zinc finger protein 75A isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC004232, AC025283
    Conserved Domains (2) summary
    COG5048
    Location:41178
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:7393
    ZF_C2H2; C2H2 Zn finger [structural motif]
  5. NM_001352497.2NP_001339426.1  zinc finger protein 75A isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC004232, AC025283
    Conserved Domains (2) summary
    COG5048
    Location:41178
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:7393
    ZF_C2H2; C2H2 Zn finger [structural motif]
  6. NM_001352498.2NP_001339427.1  zinc finger protein 75A isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC004232, AC025283
    Conserved Domains (2) summary
    COG5048
    Location:41178
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:7393
    ZF_C2H2; C2H2 Zn finger [structural motif]
  7. NM_153028.4NP_694573.1  zinc finger protein 75A isoform 2

    See identical proteins and their annotated locations for NP_694573.1

    Status: VALIDATED

    Source sequence(s)
    AC025283, AK056091, CR749782
    Consensus CDS
    CCDS10501.1
    UniProtKB/Swiss-Prot
    Q96N20
    UniProtKB/TrEMBL
    Q68CU0
    Related
    ENSP00000459566.1, ENST00000574298.6
    Conserved Domains (3) summary
    smart00349
    Location:155
    KRAB; krueppel associated box
    COG5048
    Location:159296
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:191211
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    3305478..3322999
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017023645.2XP_016879134.1  zinc finger protein 75A isoform X5

  2. XM_017023644.2XP_016879133.1  zinc finger protein 75A isoform X4

  3. XM_011522646.3XP_011520948.1  zinc finger protein 75A isoform X1

    Conserved Domains (8) summary
    smart00431
    Location:50153
    SCAN; leucine rich region
    smart00349
    Location:235294
    KRAB; krueppel associated box
    COG5048
    Location:363500
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:395415
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:449471
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:235274
    KRAB; KRAB box
    pfam02023
    Location:44132
    SCAN; SCAN domain
    pfam13465
    Location:379402
    zf-H2C2_2; Zinc-finger double domain
  4. XM_017023643.2XP_016879132.1  zinc finger protein 75A isoform X3

  5. XM_011522647.2XP_011520949.1  zinc finger protein 75A isoform X2

    See identical proteins and their annotated locations for XP_011520949.1

    UniProtKB/Swiss-Prot
    Q96N20
    Conserved Domains (3) summary
    smart00349
    Location:155
    KRAB; krueppel associated box
    COG5048
    Location:159296
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:191211
    ZF_C2H2; C2H2 Zn finger [structural motif]
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