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Fads1 fatty acid desaturase 1 [ Mus musculus (house mouse) ]

Gene ID: 76267, updated on 18-May-2023

Summary

Official Symbol
Fads1provided by MGI
Official Full Name
fatty acid desaturase 1provided by MGI
Primary source
MGI:MGI:1923517
See related
Ensembl:ENSMUSG00000010663 AllianceGenome:MGI:1923517
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DSD; 0710001O03Rik; A930006B21Rik
Summary
Enables acyl-CoA delta5-desaturase activity. Predicted to be involved in arachidonic acid metabolic process and cellular response to starvation. Predicted to act upstream of or within long-chain fatty acid biosynthetic process and unsaturated fatty acid biosynthetic process. Predicted to be located in nucleus. Is expressed in several structures, including alimentary system; eye; genitourinary system; nervous system; and respiratory system. Orthologous to human FADS1 (fatty acid desaturase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 116.7), liver adult (RPKM 83.2) and 23 other tissues See more
Orthologs
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Genomic context

See Fads1 in Genome Data Viewer
Location:
19; 19 A
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_04 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (10160245..10174238)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (10182877..10196874)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:10138709-10138947 Neighboring gene fatty acid desaturase 2 Neighboring gene vesicle-associated membrane protein 3 pseudogene Neighboring gene microRNA 6993 Neighboring gene transmembrane protein 258 Neighboring gene flap structure specific endonuclease 1 Neighboring gene myelin regulatory factor

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC37858

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
acyl-CoA (8-3)-desaturase
Names
D5D
delta(5) desaturase
delta(5) fatty acid desaturase
NP_666206.1
XP_006527501.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_146094.2NP_666206.1  acyl-CoA (8-3)-desaturase

    See identical proteins and their annotated locations for NP_666206.1

    Status: VALIDATED

    Source sequence(s)
    AC132148, AK083959, BC063053
    Consensus CDS
    CCDS29572.1
    UniProtKB/Swiss-Prot
    Q8VC07, Q920L1
    UniProtKB/TrEMBL
    A0A8C6I6Q8, X2EXD0
    Related
    ENSMUSP00000010807.5, ENSMUST00000010807.6
    Conserved Domains (3) summary
    PLN03199
    Location:12442
    PLN03199; delta6-acyl-lipid desaturase-like protein; Provisional
    cd03506
    Location:164415
    Delta6-FADS-like; The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases ...
    pfam00173
    Location:2196
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2023_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    10160245..10174238
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527438.3XP_006527501.1  acyl-CoA (8-3)-desaturase isoform X1

    Conserved Domains (1) summary
    cd03506
    Location:40291
    Delta6-FADS-like; The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases ...