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Gstk1 glutathione S-transferase kappa 1 [ Mus musculus (house mouse) ]

Gene ID: 76263, updated on 27-Feb-2024

Summary

Official Symbol
Gstk1provided by MGI
Official Full Name
glutathione S-transferase kappa 1provided by MGI
Primary source
MGI:MGI:1923513
See related
Ensembl:ENSMUSG00000029864 AllianceGenome:MGI:1923513
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DsbA-L; 0610025I19Rik
Summary
Enables glutathione peroxidase activity and glutathione transferase activity. Acts upstream of or within glutathione metabolic process. Located in mitochondrion. Orthologous to human GSTK1 (glutathione S-transferase kappa 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver adult (RPKM 68.9), adrenal adult (RPKM 41.8) and 19 other tissues See more
Orthologs
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Genomic context

See Gstk1 in Genome Data Viewer
Location:
6 B2.1; 6 20.52 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (42222869..42227375)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (42245935..42250441)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene taste receptor, type 2, member 139 Neighboring gene taste receptor, type 2, member 144 Neighboring gene STARR-positive B cell enhancer mm9_chr6:42195755-42196055 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:42214692-42214906 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:42214909-42215092 Neighboring gene transmembrane protein 139 Neighboring gene caspase 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables glutathione peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables glutathione peroxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables glutathione peroxidase activity ISO
Inferred from Sequence Orthology
more info
 
enables glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables glutathione transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables glutathione transferase activity ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in glutathione metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within glutathione metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane HDA PubMed 
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
glutathione S-transferase kappa 1
Names
GST 13-13
GST class-kappa
GSTK1-1
glutathione S-transferase class kappa
glutathione S-transferase subunit 13
mGSTK1
NP_083831.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029555.2NP_083831.1  glutathione S-transferase kappa 1

    See identical proteins and their annotated locations for NP_083831.1

    Status: PROVISIONAL

    Source sequence(s)
    AC155654
    Consensus CDS
    CCDS20063.1
    UniProtKB/Swiss-Prot
    Q9DCM2
    Related
    ENSMUSP00000031897.6, ENSMUST00000031897.8
    Conserved Domains (1) summary
    cd03021
    Location:6211
    DsbA_GSTK; DsbA family, Glutathione (GSH) S-transferase Kappa (GSTK) subfamily; GSTK is a member of the GST family of enzymes which catalyzes the transfer of the thiol of GSH to electrophilic substrates. It is specifically located in the mitochondria and ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    42222869..42227375
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)