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ZNF75D zinc finger protein 75D [ Homo sapiens (human) ]

Gene ID: 7626, updated on 12-Oct-2019

Summary

Official Symbol
ZNF75Dprovided by HGNC
Official Full Name
zinc finger protein 75Dprovided by HGNC
Primary source
HGNC:HGNC:13145
See related
Ensembl:ENSG00000186376 MIM:314997
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
D8C6; ZNF75; ZNF82; ZSCAN28; ZKSCAN24
Summary
This gene encodes a protein that likely functions as a transcription factor. The protein, which belongs to the ZNF75 family, includes an N-terminal SCAN domain, a KRAB box, and five C2H2-type zinc finger motifs. Another functional gene belonging to this family is located on chromosome 16, while pseudogenes have been identified on chromosomes 11 and 12. Alternative splicing results in multiple transcripts variants. [provided by RefSeq, Jun 2010]
Expression
Ubiquitous expression in prostate (RPKM 3.8), adrenal (RPKM 3.6) and 25 other tissues See more
Orthologs

Genomic context

See ZNF75D in Genome Data Viewer
Location:
Xq26.3
Exon count:
10
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (135248589..135344629, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (134419719..134478034, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene cancer/testis antigen 55 pseudogene Neighboring gene zinc finger protein 449 pseudogene Neighboring gene embryonic testis differentiation homolog A Neighboring gene tigger transposable element derived 7 pseudogene Neighboring gene uncharacterized LOC105373342 Neighboring gene embryonic testis differentiation homolog C Neighboring gene zinc finger protein 449 Neighboring gene uncharacterized LOC100506790

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from BioSystems

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...

General gene information

Markers

Homology

Clone Names

  • MGC126327

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger protein 75D
Names
zinc finger protein 75
zinc finger protein 82

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021412.2 RefSeqGene

    Range
    4979..63297
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001185063.2NP_001171992.1  zinc finger protein 75D isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks two in-frame exons, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK091687, AL832801, CB241691, DA412890
    Consensus CDS
    CCDS55503.1
    UniProtKB/Swiss-Prot
    P51815
    Related
    ENSP00000359800.1, ENST00000370764.1
    Conserved Domains (8) summary
    smart00431
    Location:45155
    SCAN; leucine rich region
    smart00349
    Location:140185
    KRAB; krueppel associated box
    COG5048
    Location:283397
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:300320
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:270292
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:140179
    KRAB; KRAB box
    pfam02023
    Location:45133
    SCAN; SCAN domain
    pfam13465
    Location:343365
    zf-H2C2_2; Zinc-finger double domain
  2. NM_007131.5NP_009062.2  zinc finger protein 75D isoform 1

    See identical proteins and their annotated locations for NP_009062.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL450472, AL831984, AL832801, BC029787
    Consensus CDS
    CCDS14648.1
    UniProtKB/Swiss-Prot
    P51815
    UniProtKB/TrEMBL
    Q86TD5
    Related
    ENSP00000359802.3, ENST00000370766.8
    Conserved Domains (5) summary
    COG5048
    Location:378492
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:395415
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:365387
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:234275
    KRAB; KRAB box
    pfam02023
    Location:45133
    SCAN; SCAN domain

RNA

  1. NR_110381.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has multiple differences compared to variant 1, including containing three alternate 3' exons. This variant is represented as non-coding because it lacks the entire coding region found in variant 1.
    Source sequence(s)
    AI264634, AL450472, AL831984, BC029787, CF530049
    Related
    ENST00000494295.1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    135248589..135344629 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531395.3XP_011529697.1  zinc finger protein 75D isoform X1

    Conserved Domains (6) summary
    smart00349
    Location:85130
    KRAB; krueppel associated box
    COG5048
    Location:228342
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:245265
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:215237
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:85124
    KRAB; KRAB box
    pfam13465
    Location:288310
    zf-H2C2_2; Zinc-finger double domain
  2. XM_017029820.2XP_016885309.1  zinc finger protein 75D isoform X5

    Conserved Domains (6) summary
    smart00349
    Location:64109
    KRAB; krueppel associated box
    COG5048
    Location:207321
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:224244
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:194216
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:64103
    KRAB; KRAB box
    pfam13465
    Location:267289
    zf-H2C2_2; Zinc-finger double domain
  3. XM_011531397.3XP_011529699.1  zinc finger protein 75D isoform X5

    Conserved Domains (6) summary
    smart00349
    Location:64109
    KRAB; krueppel associated box
    COG5048
    Location:207321
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:224244
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:194216
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:64103
    KRAB; KRAB box
    pfam13465
    Location:267289
    zf-H2C2_2; Zinc-finger double domain
  4. XM_017029819.2XP_016885308.1  zinc finger protein 75D isoform X4

  5. XM_024452445.1XP_024308213.1  zinc finger protein 75D isoform X7

    Conserved Domains (2) summary
    COG5048
    Location:115229
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:132152
    ZF_C2H2; C2H2 Zn finger [structural motif]
  6. XM_024452446.1XP_024308214.1  zinc finger protein 75D isoform X8

    Conserved Domains (2) summary
    COG5048
    Location:71185
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:88108
    ZF_C2H2; C2H2 Zn finger [structural motif]
  7. XM_024452444.1XP_024308212.1  zinc finger protein 75D isoform X7

    Conserved Domains (2) summary
    COG5048
    Location:115229
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:132152
    ZF_C2H2; C2H2 Zn finger [structural motif]
  8. XM_024452443.1XP_024308211.1  zinc finger protein 75D isoform X7

    Conserved Domains (2) summary
    COG5048
    Location:115229
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:132152
    ZF_C2H2; C2H2 Zn finger [structural motif]
  9. XM_024452442.1XP_024308210.1  zinc finger protein 75D isoform X2

    Conserved Domains (4) summary
    COG5048
    Location:232346
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:249269
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:219241
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:88129
    KRAB; KRAB box
  10. XM_005262471.3XP_005262528.1  zinc finger protein 75D isoform X6

    See identical proteins and their annotated locations for XP_005262528.1

    Conserved Domains (6) summary
    smart00349
    Location:2873
    KRAB; krueppel associated box
    COG5048
    Location:171285
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:188208
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:158180
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:2867
    KRAB; KRAB box
    pfam13465
    Location:231253
    zf-H2C2_2; Zinc-finger double domain
  11. XM_011531396.3XP_011529698.1  zinc finger protein 75D isoform X3

    Conserved Domains (6) summary
    smart00349
    Location:67112
    KRAB; krueppel associated box
    COG5048
    Location:210324
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:227247
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:197219
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:67106
    KRAB; KRAB box
    pfam13465
    Location:270292
    zf-H2C2_2; Zinc-finger double domain
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