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Atp6v0e2 ATPase, H+ transporting, lysosomal V0 subunit E2 [ Mus musculus (house mouse) ]

Gene ID: 76252, updated on 8-Dec-2022

Summary

Official Symbol
Atp6v0e2provided by MGI
Official Full Name
ATPase, H+ transporting, lysosomal V0 subunit E2provided by MGI
Primary source
MGI:MGI:1923502
See related
Ensembl:ENSMUSG00000039347 AllianceGenome:MGI:1923502
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NM9.2; 0610006O14Rik
Summary
Predicted to enable proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in proton transmembrane transport. Predicted to act upstream of or within ion transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of proton-transporting V-type ATPase, V0 domain. Is expressed in several structures, including genitourinary system; nervous system; sensory organ; and tongue. Orthologous to human ATP6V0E2 (ATPase H+ transporting V0 subunit e2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cortex adult (RPKM 116.9), cerebellum adult (RPKM 109.2) and 20 other tissues See more
Orthologs
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Genomic context

See Atp6v0e2 in Genome Data Viewer
Location:
6; 6 B2.3
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (48514503..48518735)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (48537569..48541801)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 862, pseudogene Neighboring gene PEST proteolytic signal containing nuclear protein pseudogene Neighboring gene RIKEN cDNA 1700026J14 gene Neighboring gene leucine rich repeat containing 61 Neighboring gene retinoic acid receptor responder (tazarotene induced) 2 Neighboring gene predicted gene 5111

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables proton-transporting ATPase activity, rotational mechanism ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
part_of proton-transporting V-type ATPase, V0 domain IEA
Inferred from Electronic Annotation
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
V-type proton ATPase subunit e 2
Names
ATPase, H+ transporting, lysosomal, V0 subunit E
V-ATPase subunit e 2
vacuolar proton pump subunit e 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347164.1NP_001334093.1  V-type proton ATPase subunit e 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a longer and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC154013
    Consensus CDS
    CCDS85039.1
    UniProtKB/TrEMBL
    A0A0N4SVQ2
    Related
    ENSMUSP00000145198.2, ENSMUST00000203011.2
  2. NM_133764.3NP_598525.1  V-type proton ATPase subunit e 2 isoform 1

    See identical proteins and their annotated locations for NP_598525.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (1).
    Source sequence(s)
    AC154013, AI839056, AK077313, BY296901
    Consensus CDS
    CCDS20103.1
    UniProtKB/Swiss-Prot
    Q91XE7
    UniProtKB/TrEMBL
    A0A6P5PV67, A0A8C6HQ85
    Related
    ENSMUSP00000044110.6, ENSMUST00000040361.8
    Conserved Domains (1) summary
    pfam05493
    Location:967
    ATP_synt_H; ATP synthase subunit H

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    48514503..48518735
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)