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Atp6v0e2 ATPase, H+ transporting, lysosomal V0 subunit E2 [ Mus musculus (house mouse) ]

Gene ID: 76252, updated on 8-Apr-2026
Official Symbol
Atp6v0e2provided by MGI
Official Full Name
ATPase, H+ transporting, lysosomal V0 subunit E2provided by MGI
Primary source
MGI:MGI:1923502
See related
Ensembl:ENSMUSG00000039347 AllianceGenome:MGI:1923502
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NM9.2; 0610006O14Rik
Summary
Predicted to enable proton-transporting ATPase activity, rotational mechanism. Involved in synaptic vesicle lumen acidification. Predicted to be located in clathrin-coated vesicle membrane. Predicted to be part of vacuolar proton-transporting V-type ATPase, V0 domain. Predicted to be active in synaptic vesicle membrane. Is expressed in several structures, including genitourinary system; nervous system; sensory organ; and tongue. Orthologous to human ATP6V0E2 (ATPase H+ transporting V0 subunit e2). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Broad expression in cortex adult (RPKM 116.9), cerebellum adult (RPKM 109.2) and 20 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See Atp6v0e2 in Genome Data Viewer
Location:
6 B2.3; 6 23.52 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (48514503..48518735)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (48537569..48541801)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 862, pseudogene Neighboring gene PEST proteolytic signal containing nuclear protein pseudogene Neighboring gene RIKEN cDNA 1700026J14 gene Neighboring gene STARR-positive B cell enhancer ABC_E9271 Neighboring gene leucine rich repeat containing 61 Neighboring gene retinoic acid receptor responder (tazarotene induced) 2 Neighboring gene predicted gene 5111

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Related articles in PubMed

  1. A novel putative M9.2 isoform of V-ATPase expressed in the nervous system. Ueda T, et al. Neuroreport, 2003 Jan 20. PMID 12544825
  2. The Presynaptic v-ATPase Reversibly Disassembles and Thereby Modulates Exocytosis but Is Not Part of the Fusion Machinery. Bodzęta A, et al. Cell Rep, 2017 Aug 8. PMID 28793259
  3. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  4. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
  5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to proton-transporting ATPase activity, rotational mechanism IBA
Inferred from Biological aspect of Ancestor
more info
  
enables proton-transporting ATPase activity, rotational mechanism IEA
Inferred from Electronic Annotation
more info
  
enables proton-transporting ATPase activity, rotational mechanism ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in proton transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in proton transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in synaptic vesicle lumen acidification EXP
Inferred from Experiment
more info
 PubMed 
involved_in synaptic vesicle lumen acidification IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synaptic vesicle lumen acidification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in clathrin-coated vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of proton-transporting V-type ATPase, V0 domain IEA
Inferred from Electronic Annotation
more info
  
located_in synaptic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
  
part_of vacuolar proton-transporting V-type ATPase, V0 domain IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of vacuolar proton-transporting V-type ATPase, V0 domain ISS
Inferred from Sequence or Structural Similarity
more info
  
Preferred Names
V-type proton ATPase subunit e 2
Names
ATPase, H+ transporting, lysosomal, V0 subunit E
V-ATPase subunit e 2
vacuolar proton pump subunit e 2

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347164.1 → NP_001334093.1  V-type proton ATPase subunit e 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a longer and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC154013
    Consensus CDS
    CCDS85039.1
    UniProtKB/TrEMBL
    A0A0N4SVQ2
    Related
    ENSMUSP00000145198.2, ENSMUST00000203011.2

  2. NM_133764.3 → NP_598525.1  V-type proton ATPase subunit e 2 isoform 1

    See identical proteins and their annotated locations for NP_598525.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (1).
    Source sequence(s)
    AC154013, AI839056, AK077313, BY296901
    Consensus CDS
    CCDS20103.1
    UniProtKB/Swiss-Prot
    Q91XE7
    Related
    ENSMUSP00000044110.6, ENSMUST00000040361.8
    Conserved Domains (1) summary
    pfam05493
    Location:9 → 67
    ATP_synt_H; ATP synthase subunit H

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    48514503..48518735
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91XE7.1 GenPept UniProtKB/Swiss-Prot:Q91XE7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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