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Ercc6l2 excision repair cross-complementing rodent repair deficiency, complementation group 6 like 2 [ Mus musculus (house mouse) ]

Gene ID: 76251, updated on 31-Jan-2019

Summary

Official Symbol
Ercc6l2provided by MGI
Official Full Name
excision repair cross-complementing rodent repair deficiency, complementation group 6 like 2provided by MGI
Primary source
MGI:MGI:1923501
See related
Ensembl:ENSMUSG00000021470
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sr278; Rad26l; 0610007P08Rik; 1700019D06Rik; 9330134C04Rik
Expression
Ubiquitous expression in adrenal adult (RPKM 2.2), bladder adult (RPKM 2.2) and 28 other tissues See more
Orthologs

Genomic context

See Ercc6l2 in Genome Data Viewer
Location:
13; 13 B3
Exon count:
20
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (63815058..63900302)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (63916628..64001610)

Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 30709 Neighboring gene RIKEN cDNA 1700024I08 gene Neighboring gene predicted gene, 46423 Neighboring gene predicted gene, 30950

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

General gene information

Homology

Clone Names

  • MGC100170

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
helicase activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
DNA repair IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to reactive oxygen species ISO
Inferred from Sequence Orthology
more info
 
interstrand cross-link repair ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
colocalizes_with centrosome ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
DNA excision repair protein ERCC-6-like 2
Names
DNA repair and recombination protein RAD26-like
putative repair and recombination helicase RAD26L
stretch responsive protein 278

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013608.3NP_001013626.2  DNA excision repair protein ERCC-6-like 2 isoform 1

    See identical proteins and their annotated locations for NP_001013626.2

    Status: VALIDATED

    Source sequence(s)
    AC154248
    UniProtKB/Swiss-Prot
    Q9JIM3
    Conserved Domains (4) summary
    cd00046
    Location:141300
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam00176
    Location:125460
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:505619
    Helicase_C; Helicase conserved C-terminal domain
    pfam14773
    Location:11081131
    VIGSSK; Helicase-associated putative binding domain, C-terminal
  2. NM_001361124.1NP_001348053.1  DNA excision repair protein ERCC-6-like 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC154248, AK082850
    Conserved Domains (1) summary
    COG0553
    Location:81466
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
  3. NM_023507.4NP_075996.2  DNA excision repair protein ERCC-6-like 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154248
    Consensus CDS
    CCDS36701.1
    UniProtKB/Swiss-Prot
    Q9JIM3
    Related
    ENSMUSP00000069488.5, ENSMUST00000067821.12
    Conserved Domains (3) summary
    cd00046
    Location:141300
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam00176
    Location:125460
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:505619
    Helicase_C; Helicase conserved C-terminal domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

    Range
    63815058..63900302
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517451.3XP_006517514.1  DNA excision repair protein ERCC-6-like 2 isoform X4

    Conserved Domains (4) summary
    cd00046
    Location:141300
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam00176
    Location:125460
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:505619
    Helicase_C; Helicase conserved C-terminal domain
    pfam14773
    Location:11081131
    VIGSSK; Helicase-associated putative binding domain, C-terminal
  2. XM_017315632.1XP_017171121.1  DNA excision repair protein ERCC-6-like 2 isoform X1

  3. XM_017315633.1XP_017171122.1  DNA excision repair protein ERCC-6-like 2 isoform X2

  4. XM_006517450.1XP_006517513.1  DNA excision repair protein ERCC-6-like 2 isoform X3

    Conserved Domains (3) summary
    COG0553
    Location:2364
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    pfam00271
    Location:220334
    Helicase_C; Helicase conserved C-terminal domain
    pfam14773
    Location:823846
    VIGSSK; Helicase-associated putative binding domain, C-terminal
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