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Ercc6l2 excision repair cross-complementing rodent repair deficiency, complementation group 6 like 2 [ Mus musculus (house mouse) ]

Gene ID: 76251, updated on 9-Mar-2023

Summary

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Official Symbol
Ercc6l2provided by MGI
Official Full Name
excision repair cross-complementing rodent repair deficiency, complementation group 6 like 2provided by MGI
Primary source
MGI:MGI:1923501
See related
Ensembl:ENSMUSG00000021470 AllianceGenome:MGI:1923501
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sr278; Rad26l; 0610007P08Rik; 1700019D06Rik; 9330134C04Rik
Summary
Predicted to enable protein kinase binding activity. Predicted to be involved in cellular response to reactive oxygen species and interstrand cross-link repair. Predicted to act upstream of or within DNA repair. Predicted to be located in mitochondrion and nucleus. Predicted to be part of protein-containing complex. Predicted to colocalize with centrosome. Orthologous to human ERCC6L2 (ERCC excision repair 6 like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 2.2), bladder adult (RPKM 2.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ercc6l2 in Genome Data Viewer
Location:
13; 13 B3
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (63958793..64048116)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (63810979..63900302)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm702 Neighboring gene predicted gene, 30709 Neighboring gene RIKEN cDNA 1700024I08 gene Neighboring gene predicted gene, 46423 Neighboring gene predicted gene, 30950

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ERCC6L2 promotes DNA orientation-specific recombination in mammalian cells. Liu X, et al. Cell Res, 2020 Sep. PMID 32355287, Free PMC Article
  2. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Mural RJ, et al. Science, 2002 May 31. PMID 12040188
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (16) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ERCC6L2 promotes DNA orientation-specific recombination in mammalian cells.
    Title: ERCC6L2 promotes DNA orientation-specific recombination in mammalian cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (6)  1 citation

General gene information

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Homology

Clone Names

  • MGC100170

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent chromatin remodeler activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to reactive oxygen species ISO
Inferred from Sequence Orthology
more info
  
involved_in interstrand cross-link repair ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
colocalizes_with centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DNA excision repair protein ERCC-6-like 2
Names
DNA repair and recombination protein RAD26-like
putative repair and recombination helicase RAD26L
stretch responsive protein 278

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013608.4 → NP_001013626.2  DNA excision repair protein ERCC-6-like 2 isoform 1

    See identical proteins and their annotated locations for NP_001013626.2

    Status: VALIDATED

    Source sequence(s)
    AC154248
    Consensus CDS
    CCDS26593.2
    UniProtKB/Swiss-Prot
    Q9DD01, Q9JIM3
    Related
    ENSMUSP00000158755.2, ENSMUST00000238465.2
    Conserved Domains (4) summary
    COG0553
    Location:72 → 649
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    cd18005
    Location:122 → 369
    DEXHc_ERCC6L2; DEXH-box helicase domain of ERCC6L2
    pfam14773
    Location:1108 → 1131
    VIGSSK; Helicase-associated putative binding domain, C-terminal
    cl02573
    Location:17 → 72
    Tudor_SF; Tudor domain superfamily

  2. NM_001361124.2 → NP_001348053.1  DNA excision repair protein ERCC-6-like 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC154248
    Related
    ENSMUSP00000021926.7, ENSMUST00000021926.13
    Conserved Domains (1) summary
    COG0553
    Location:81 → 466
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]

  3. NM_023507.5 → NP_075996.2  DNA excision repair protein ERCC-6-like 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154248
    Consensus CDS
    CCDS36701.1
    UniProtKB/Swiss-Prot
    Q9JIM3
    Related
    ENSMUSP00000069488.6, ENSMUST00000067821.13
    Conserved Domains (3) summary
    cd00046
    Location:141 → 300
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam00176
    Location:125 → 460
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:505 → 619
    Helicase_C; Helicase conserved C-terminal domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    63958793..64048116
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517451.4 → XP_006517514.1  DNA excision repair protein ERCC-6-like 2 isoform X4

    Conserved Domains (4) summary
    cd04508
    Location:20 → 70
    TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
    COG0553
    Location:72 → 649
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    cd18005
    Location:122 → 369
    DEXHc_ERCC6L2; DEXH-box helicase domain of ERCC6L2
    pfam14773
    Location:1101 → 1131
    VIGSSK; Helicase-associated putative binding domain, C-terminal

  2. XM_017315632.2 → XP_017171121.1  DNA excision repair protein ERCC-6-like 2 isoform X1

    Conserved Domains (3) summary
    COG0553
    Location:72 → 649
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    cd18005
    Location:122 → 369
    DEXHc_ERCC6L2; DEXH-box helicase domain of ERCC6L2
    pfam14773
    Location:1074 → 1104
    VIGSSK; Helicase-associated putative binding domain, C-terminal

  3. XM_017315633.2 → XP_017171122.1  DNA excision repair protein ERCC-6-like 2 isoform X2

    Conserved Domains (3) summary
    COG0553
    Location:72 → 609
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    cd18005
    Location:122 → 329
    DEXHc_ERCC6L2; DEXH-box helicase domain of ERCC6L2
    pfam14773
    Location:1061 → 1091
    VIGSSK; Helicase-associated putative binding domain, C-terminal

  4. XM_030247457.1 → XP_030103317.1  DNA excision repair protein ERCC-6-like 2 isoform X3

    Conserved Domains (3) summary
    COG0553
    Location:2 → 364
    HepA; Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination and repair]
    cd18793
    Location:219 → 345
    SF2_C_SNF; C-terminal helicase domain of the SNF family helicases
    pfam14773
    Location:816 → 846
    VIGSSK; Helicase-associated putative binding domain, C-terminal
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JIM3.3 GenPept UniProtKB/Swiss-Prot:Q9JIM3

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