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Agbl3 ATP/GTP binding protein-like 3 [ Mus musculus (house mouse) ]

Gene ID: 76223, updated on 8-Dec-2022

Summary

Official Symbol
Agbl3provided by MGI
Official Full Name
ATP/GTP binding protein-like 3provided by MGI
Primary source
MGI:MGI:1923473
See related
Ensembl:ENSMUSG00000038836 AllianceGenome:MGI:1923473
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CCP3; 2900053G10Rik; 4930431N21Rik; 6530406M24Rik
Summary
Enables metallocarboxypeptidase activity. Involved in protein side chain deglutamylation. Predicted to be located in cytosol. Is expressed in brain. Orthologous to human AGBL3 (AGBL carboxypeptidase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 4.2), CNS E18 (RPKM 1.2) and 21 other tissues See more
Orthologs
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Genomic context

See Agbl3 in Genome Data Viewer
Location:
6; 6 B1
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (34755249..34837874)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (34780432..34860939)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene caldesmon 1 Neighboring gene predicted gene 13861 Neighboring gene predicted gene, 38787 Neighboring gene ribosomal protein L7A pseudogene Neighboring gene predicted gene, 46957 Neighboring gene transmembrane protein 140 Neighboring gene cell cycle regulator of NHEJ Neighboring gene WD repeat domain 91

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metallocarboxypeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables metallocarboxypeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables metallocarboxypeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables metallocarboxypeptidase activity TAS
Traceable Author Statement
more info
 
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in protein side chain deglutamylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein side chain deglutamylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein side chain deglutamylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein side chain deglutamylation TAS
Traceable Author Statement
more info
 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
cytosolic carboxypeptidase 3
Names
protein deglutamylase CCP3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289656.1NP_001276585.1  cytosolic carboxypeptidase 3 isoform 1

    See identical proteins and their annotated locations for NP_001276585.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC153869, AK029793, AK029798
    Consensus CDS
    CCDS80515.1
    UniProtKB/Swiss-Prot
    Q8CDP0, Q8R036
    Related
    ENSMUSP00000110668.2, ENSMUST00000115016.8
    Conserved Domains (1) summary
    cd06907
    Location:315576
    M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
  2. NM_001289657.1NP_001276586.1  cytosolic carboxypeptidase 3 isoform 3

    See identical proteins and their annotated locations for NP_001276586.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains multiple differences in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AC153627, AC153869, AK029793, AK029798
    UniProtKB/Swiss-Prot
    Q8CDP0
    Conserved Domains (1) summary
    cd06907
    Location:81333
    M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
  3. NM_001289658.1NP_001276587.1  cytosolic carboxypeptidase 3 isoform 4

    See identical proteins and their annotated locations for NP_001276587.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks multiple 3' coding exons and its transcription extends past a splice site used in variant 1, resulting in a different 3' coding region and 3' UTR. The encoded isoform (4) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC153627, AK029793, BC028521
    Consensus CDS
    CCDS80516.1
    UniProtKB/Swiss-Prot
    Q8CDP0
    Related
    ENSMUSP00000110666.2, ENSMUST00000115014.8
  4. NM_178630.4NP_848745.2  cytosolic carboxypeptidase 3 isoform 2

    See identical proteins and their annotated locations for NP_848745.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC153627, AC153869
    Consensus CDS
    CCDS19995.2
    UniProtKB/Swiss-Prot
    Q8CDP0
    Related
    ENSMUSP00000110669.2, ENSMUST00000115017.8
    Conserved Domains (2) summary
    cd06907
    Location:319571
    M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
    pfam18027
    Location:171297
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    34755249..34837874
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030255658.2XP_030111518.1  cytosolic carboxypeptidase 3 isoform X1

    Conserved Domains (2) summary
    cd06907
    Location:319571
    M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
    pfam18027
    Location:171297
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain
  2. XM_006506731.5XP_006506794.1  cytosolic carboxypeptidase 3 isoform X2

    Conserved Domains (2) summary
    cd06907
    Location:307559
    M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
    pfam18027
    Location:163285
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain
  3. XM_006506734.5XP_006506797.1  cytosolic carboxypeptidase 3 isoform X4

    Conserved Domains (2) summary
    cd06907
    Location:319571
    M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
    pfam18027
    Location:171297
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain
  4. XM_030255660.2XP_030111520.1  cytosolic carboxypeptidase 3 isoform X6

    UniProtKB/TrEMBL
    D6RI59
    Related
    ENSMUSP00000118303.2, ENSMUST00000135304.8
  5. XM_030255659.2XP_030111519.1  cytosolic carboxypeptidase 3 isoform X5

  6. XM_030255661.2XP_030111521.1  cytosolic carboxypeptidase 3 isoform X7

  7. XM_011241501.2XP_011239803.1  cytosolic carboxypeptidase 3 isoform X3

    See identical proteins and their annotated locations for XP_011239803.1

    Conserved Domains (1) summary
    cd06907
    Location:81333
    M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins

RNA

  1. XR_377500.5 RNA Sequence

  2. XR_377501.5 RNA Sequence

  3. XR_004933646.1 RNA Sequence