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Stard3nl STARD3 N-terminal like [ Mus musculus (house mouse) ]

Gene ID: 76205, updated on 5-Mar-2024

Summary

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Official Symbol
Stard3nlprovided by MGI
Official Full Name
STARD3 N-terminal likeprovided by MGI
Primary source
MGI:MGI:1923455
See related
Ensembl:ENSMUSG00000003062 AllianceGenome:MGI:1923455
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MENTHO; 0610035N01Rik; 6530409L22Rik
Summary
Predicted to enable cholesterol binding activity and protein homodimerization activity. Predicted to be involved in vesicle tethering to endoplasmic reticulum. Predicted to be located in endoplasmic reticulum-endosome membrane contact site and late endosome membrane. Predicted to colocalize with endoplasmic reticulum membrane. Is expressed in respiratory system cartilage; sensory organ; skeleton; and tarsus. Orthologous to human STARD3NL (STARD3 N-terminal like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 24.1), whole brain E14.5 (RPKM 18.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Stard3nl in Genome Data Viewer
Location:
13 A2; 13 6.89 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (19541846..19579983, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (19357676..19395813, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene T cell receptor gamma chain Neighboring gene T cell receptor gamma joining 4 Neighboring gene T cell receptor gamma, constant 4 Neighboring gene STARR-seq mESC enhancer starr_33793 Neighboring gene STARR-positive B cell enhancer mm9_chr13:19487566-19487867 Neighboring gene predicted gene, 40827 Neighboring gene STARR-seq mESC enhancer starr_33795 Neighboring gene cofilin 1, non-muscle pseudogene Neighboring gene RIKEN cDNA 9330199G10 gene Neighboring gene STARR-seq mESC enhancer starr_33796

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MENTHO, a MLN64 homologue devoid of the START domain. Alpy F, et al. J Biol Chem, 2002 Dec 27. PMID 12393907
  2. STARD3NL inhibits the osteogenic differentiation by inactivating the Wnt/β-catenin pathway via binding to Annexin A2 in osteoporosis. Xu Y, et al. J Cell Mol Med, 2022 Mar. PMID 35098646, Free PMC Article
  3. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
  4. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
  5. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. STARD3NL inhibits the osteogenic differentiation by inactivating the Wnt/beta-catenin pathway via binding to Annexin A2 in osteoporosis.
    Title: STARD3NL inhibits the osteogenic differentiation by inactivating the Wnt/β-catenin pathway via binding to Annexin A2 in osteoporosis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cholesterol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cholesterol binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cholesterol transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle tethering to endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle tethering to endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
colocalizes_with endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum-endosome membrane contact site IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum-endosome membrane contact site ISO
Inferred from Sequence Orthology
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in late endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in late endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in organelle membrane contact site ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
STARD3 N-terminal-like protein
Names
MLN64 N-terminal domain homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347485.1 → NP_001334414.1  STARD3 N-terminal-like protein isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two 3' exons but contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is longer than isoform a.
    Source sequence(s)
    AK018331, BG071347, CJ135250, DV648392
    Consensus CDS
    CCDS84008.1
    UniProtKB/TrEMBL
    A0A0G2JE93, Q3U852
    Related
    ENSMUSP00000142680.2, ENSMUST00000200323.3

  2. NM_024270.3 → NP_077232.2  STARD3 N-terminal-like protein isoform a

    See identical proteins and their annotated locations for NP_077232.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (a).
    Source sequence(s)
    BG084215, BP772163, CO039188, DV648392
    Consensus CDS
    CCDS26259.1
    UniProtKB/Swiss-Prot
    Q3U8Q7, Q99J63, Q9D356, Q9DCI3
    UniProtKB/TrEMBL
    Q3U852
    Related
    ENSMUSP00000037991.8, ENSMUST00000039694.13
    Conserved Domains (1) summary
    pfam10457
    Location:49 → 212
    MENTAL; Cholesterol-capturing domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    19541846..19579983 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158216.1 → XP_036014109.1  STARD3 N-terminal-like protein isoform X2

    UniProtKB/TrEMBL
    Q3U852
    Conserved Domains (1) summary
    pfam10457
    Location:104 → 267
    MENTAL; Cholesterol-capturing domain

  2. XM_036158217.1 → XP_036014110.1  STARD3 N-terminal-like protein isoform X3

    UniProtKB/Swiss-Prot
    Q3U8Q7, Q99J63, Q9D356, Q9DCI3
    UniProtKB/TrEMBL
    Q3U852
    Conserved Domains (1) summary
    pfam10457
    Location:49 → 212
    MENTAL; Cholesterol-capturing domain

  3. XM_030247456.1 → XP_030103316.1  STARD3 N-terminal-like protein isoform X3

    UniProtKB/Swiss-Prot
    Q3U8Q7, Q99J63, Q9D356, Q9DCI3
    UniProtKB/TrEMBL
    Q3U852
    Conserved Domains (1) summary
    pfam10457
    Location:49 → 212
    MENTAL; Cholesterol-capturing domain

  4. XM_030247454.2 → XP_030103314.1  STARD3 N-terminal-like protein isoform X1

    Conserved Domains (1) summary
    pfam10457
    Location:104 → 268
    MENTAL; Cholesterol-capturing domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DCI3.2 GenPept UniProtKB/Swiss-Prot:Q9DCI3

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