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Med13l mediator complex subunit 13-like [ Mus musculus (house mouse) ]

Gene ID: 76199, updated on 4-May-2024

Summary

Official Symbol
Med13lprovided by MGI
Official Full Name
mediator complex subunit 13-likeprovided by MGI
Primary source
MGI:MGI:2670178
See related
Ensembl:ENSMUSG00000018076 AllianceGenome:MGI:2670178
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Thrap2; Trap240L; mKIAA1025; 2210413I17Rik; 6330591G05Rik; 9030618F05Rik
Summary
Predicted to enable transcription coregulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within transcription by RNA polymerase II. Part of mediator complex. Human ortholog(s) of this gene implicated in dextro-looped transposition of the great arteries. Orthologous to human MED13L (mediator complex subunit 13L). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 10.1), spleen adult (RPKM 6.5) and 28 other tissues See more
Orthologs
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Genomic context

See Med13l in Genome Data Viewer
Location:
5 F; 5 59.1 cM
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (118698363..118903503)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (118560330..118765438)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene basic transcription factor 3, pseudogene 11 Neighboring gene predicted gene, 46921 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:119020268-119020484 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:119040971-119041080 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:119126693-119126894 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:119128855-119129008 Neighboring gene STARR-seq mESC enhancer starr_14210 Neighboring gene predicted gene, 42015 Neighboring gene RIKEN cDNA 4930413E15 gene Neighboring gene STARR-seq mESC enhancer starr_14211

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4)  1 citation
  • Targeted (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of mediator complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
mediator of RNA polymerase II transcription subunit 13-like
Names
thyroid hormone receptor associated protein 2
thyroid hormone receptor-associated protein complex 240 kDa component-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347445.2NP_001334374.1  mediator of RNA polymerase II transcription subunit 13-like isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC117585, AC129552
    Consensus CDS
    CCDS84948.1
    UniProtKB/Swiss-Prot
    Q3TRF4, Q3UQI8, Q6JPI3, Q80TM3, Q80WQ0
    UniProtKB/TrEMBL
    A0A0J9YUA8
    Related
    ENSMUSP00000144092.2, ENSMUST00000201010.2
  2. NM_172424.5NP_766012.3  mediator of RNA polymerase II transcription subunit 13-like isoform 2

    See identical proteins and their annotated locations for NP_766012.3

    Status: VALIDATED

    Source sequence(s)
    AC117585, AC129552
    Consensus CDS
    CCDS57375.1
    UniProtKB/Swiss-Prot
    Q3TRF4, Q3UQI8, Q6JPI3, Q80TM3, Q80WQ0
    UniProtKB/TrEMBL
    E9QLJ3
    Related
    ENSMUSP00000098379.5, ENSMUST00000100816.8
    Conserved Domains (2) summary
    pfam06333
    Location:16752194
    Med13_C; Mediator complex subunit 13 C-terminal
    pfam11597
    Location:16380
    Med13_N; Mediator complex subunit 13 N-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    118698363..118903503
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254882.2XP_030110742.1  mediator of RNA polymerase II transcription subunit 13-like isoform X2

    UniProtKB/Swiss-Prot
    Q3TRF4, Q3UQI8, Q6JPI3, Q80TM3, Q80WQ0
    Conserved Domains (3) summary
    pfam06333
    Location:17922195
    Med13_C; Mediator complex subunit 13 C-terminal
    pfam11597
    Location:11287
    Med13_N; Mediator complex subunit 13 N-terminal
    pfam18296
    Location:14141756
    MID_MedPIWI; MID domain of medPIWI
  2. XM_011248248.4XP_011246550.1  mediator of RNA polymerase II transcription subunit 13-like isoform X1

    UniProtKB/Swiss-Prot
    Q3TRF4, Q3UQI8, Q6JPI3, Q80TM3, Q80WQ0
    Conserved Domains (3) summary
    pfam06333
    Location:17922204
    Med13_C; Mediator complex subunit 13 C-terminal
    pfam11597
    Location:11287
    Med13_N; Mediator complex subunit 13 N-terminal
    pfam18296
    Location:14141756
    MID_MedPIWI; MID domain of medPIWI
  3. XM_036165591.1XP_036021484.1  mediator of RNA polymerase II transcription subunit 13-like isoform X3

    UniProtKB/Swiss-Prot
    Q3TRF4, Q3UQI8, Q6JPI3, Q80TM3, Q80WQ0
    Conserved Domains (2) summary
    pfam06333
    Location:16592071
    Med13_C; Mediator complex subunit 13 C-terminal
    pfam18296
    Location:12811623
    MID_MedPIWI; MID domain of medPIWI
  4. XM_030254883.1XP_030110743.1  mediator of RNA polymerase II transcription subunit 13-like isoform X3

    UniProtKB/Swiss-Prot
    Q3TRF4, Q3UQI8, Q6JPI3, Q80TM3, Q80WQ0
    Conserved Domains (2) summary
    pfam06333
    Location:16592071
    Med13_C; Mediator complex subunit 13 C-terminal
    pfam18296
    Location:12811623
    MID_MedPIWI; MID domain of medPIWI