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Cplane2 ciliogenesis and planar polarity effector 2 [ Mus musculus (house mouse) ]

Gene ID: 76166, updated on 10-Jun-2024

Summary

Official Symbol
Cplane2provided by MGI
Official Full Name
ciliogenesis and planar polarity effector 2provided by MGI
Primary source
MGI:MGI:1923416
See related
Ensembl:ENSMUSG00000073733 AllianceGenome:MGI:1923416
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rsg1; Gm723; b2b2804Clo; b2b2827Clo; 6330545A04Rik
Summary
Predicted to enable GTP binding activity and GTPase activity. Predicted to act upstream of or within cell projection organization; exocytosis; and protein transport. Predicted to be located in cilium; cytoplasm; and cytoskeleton. Used to study VACTERL association and visceral heterotaxy. Orthologous to human CPLANE2 (ciliogenesis and planar polarity effector 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 1.3), ovary adult (RPKM 1.2) and 28 other tissues See more
Orthologs
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Genomic context

See Cplane2 in Genome Data Viewer
Location:
4 D3; 4 73.47 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (140941249..140947425)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (141213940..141220114)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene SUZ RNA binding domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_11890 Neighboring gene STARR-positive B cell enhancer ABC_E3533 Neighboring gene STARR-positive B cell enhancer ABC_E3534 Neighboring gene F-box protein 42 Neighboring gene STARR-seq mESC enhancer starr_11892 Neighboring gene STARR-positive B cell enhancer ABC_E10273 Neighboring gene STARR-positive B cell enhancer ABC_E3535 Neighboring gene STARR-positive B cell enhancer ABC_E6249 Neighboring gene RIKEN cDNA C630004L07 gene Neighboring gene STARR-positive B cell enhancer mm9_chr4:140795314-140795615 Neighboring gene Rho guanine nucleotide exchange factor 19 Neighboring gene predicted gene, 52686

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in centriole IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in ciliary base IDA
Inferred from Direct Assay
more info
PubMed 
located_in ciliary transition zone IDA
Inferred from Direct Assay
more info
PubMed 
located_in cilium IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ciliogenesis and planar polarity effector 2
Names
REM2 and RAB-like small GTPase 1
REM2- and Rab-like small GTPase 1
miro domain-containing protein C1orf89 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081174.2NP_001074643.1  ciliogenesis and planar polarity effector 2

    See identical proteins and their annotated locations for NP_001074643.1

    Status: VALIDATED

    Source sequence(s)
    BC147765, BY232166
    Consensus CDS
    CCDS38937.1
    UniProtKB/Swiss-Prot
    A2A825
    UniProtKB/TrEMBL
    B2RWG6
    Related
    ENSMUSP00000095422.3, ENSMUST00000097813.3
    Conserved Domains (1) summary
    cd00882
    Location:62180
    Ras_like_GTPase; Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    140941249..140947425
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_003955035.2 RNA Sequence