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Mcur1 mitochondrial calcium uniporter regulator 1 [ Mus musculus (house mouse) ]

Gene ID: 76137, updated on 4-May-2024


Official Symbol
Mcur1provided by MGI
Official Full Name
mitochondrial calcium uniporter regulator 1provided by MGI
Primary source
See related
Ensembl:ENSMUSG00000021371 AllianceGenome:MGI:1923387
Gene type
protein coding
RefSeq status
Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ccdc90a; 6230416A05Rik
Predicted to be involved in calcium import into the mitochondrion and positive regulation of mitochondrial calcium ion concentration. Predicted to act upstream of or within calcium ion transport. Predicted to be located in mitochondrial inner membrane. Predicted to be integral component of membrane. Predicted to be active in mitochondrion. Predicted to be integral component of mitochondrial inner membrane. Is expressed in brain; heart; and liver. Orthologous to human MCUR1 (mitochondrial calcium uniporter regulator 1). [provided by Alliance of Genome Resources, Apr 2022]
Ubiquitous expression in kidney adult (RPKM 29.7), adrenal adult (RPKM 20.4) and 27 other tissues See more
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Genomic context

See Mcur1 in Genome Data Viewer
13 A4; 13 21.6 cM
Exon count:
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (43691882..43714284, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (43538406..43560344, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene non-histone chromosomal protein HMG-17 pseudogene Neighboring gene predicted gene, 32939 Neighboring gene STARR-seq mESC enhancer starr_34344 Neighboring gene ring finger protein 182 Neighboring gene STARR-seq mESC enhancer starr_34345 Neighboring gene predicted gene, 52070

Genomic regions, transcripts, and products


  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a



Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2)  1 citation


Products Interactant Other Gene Complex Source Pubs Description

General gene information


Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info

General protein information

Preferred Names
mitochondrial calcium uniporter regulator 1
MCU regulator 1
coiled-coil domain containing 90A
coiled-coil domain-containing protein 90A, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081059.3NP_001074528.1  mitochondrial calcium uniporter regulator 1

    See identical proteins and their annotated locations for NP_001074528.1

    Status: VALIDATED

    Source sequence(s)
    AC124171, AK018089, AK041849, BQ174175
    Consensus CDS
    Q14DH8, Q3V3D3, Q9CXD6
    ENSMUSP00000021800.5, ENSMUST00000021800.6
    Conserved Domains (1) summary
    DUF1640; Protein of unknown function (DUF1640)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J


  1. NC_000079.7 Reference GRCm39 C57BL/6J

    43691882..43714284 complement
    GenBank, FASTA, Sequence Viewer (Graphics)


  1. XR_001780828.3 RNA Sequence

  2. XR_003950490.2 RNA Sequence