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Mcur1 mitochondrial calcium uniporter regulator 1 [ Mus musculus (house mouse) ]

Gene ID: 76137, updated on 9-Mar-2023

Summary

Official Symbol
Mcur1provided by MGI
Official Full Name
mitochondrial calcium uniporter regulator 1provided by MGI
Primary source
MGI:MGI:1923387
See related
Ensembl:ENSMUSG00000021371 AllianceGenome:MGI:1923387
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ccdc90a; 6230416A05Rik
Summary
Predicted to be involved in calcium import into the mitochondrion and positive regulation of mitochondrial calcium ion concentration. Predicted to act upstream of or within calcium ion transport. Predicted to be located in mitochondrial inner membrane. Predicted to be integral component of membrane. Predicted to be active in mitochondrion. Predicted to be integral component of mitochondrial inner membrane. Is expressed in brain; heart; and liver. Orthologous to human MCUR1 (mitochondrial calcium uniporter regulator 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 29.7), adrenal adult (RPKM 20.4) and 27 other tissues See more
Orthologs
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Genomic context

See Mcur1 in Genome Data Viewer
Location:
13; 13 A4
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (43691882..43714284, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (43538406..43560344, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene non-histone chromosomal protein HMG-17 pseudogene Neighboring gene predicted gene, 32939 Neighboring gene ring finger protein 182 Neighboring gene predicted gene, 52070

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
mitochondrial calcium uniporter regulator 1
Names
MCU regulator 1
coiled-coil domain containing 90A
coiled-coil domain-containing protein 90A, mitochondrial
NP_001074528.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081059.3NP_001074528.1  mitochondrial calcium uniporter regulator 1

    See identical proteins and their annotated locations for NP_001074528.1

    Status: VALIDATED

    Source sequence(s)
    AC124171, AK018089, AK041849, BQ174175
    Consensus CDS
    CCDS36645.1
    UniProtKB/Swiss-Prot
    Q3V3D3, Q9CXD6
    Related
    ENSMUSP00000021800.5, ENSMUST00000021800.6
    Conserved Domains (1) summary
    pfam07798
    Location:147338
    DUF1640; Protein of unknown function (DUF1640)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    43691882..43714284 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001780828.3 RNA Sequence

  2. XR_003950490.2 RNA Sequence