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Arhgap15 Rho GTPase activating protein 15 [ Mus musculus (house mouse) ]

Gene ID: 76117, updated on 17-Jan-2023

Summary

Official Symbol
Arhgap15provided by MGI
Official Full Name
Rho GTPase activating protein 15provided by MGI
Primary source
MGI:MGI:1923367
See related
Ensembl:ENSMUSG00000049744 AllianceGenome:MGI:1923367
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5830480G12Rik
Summary
The protein encoded by this gene is a RAC GTPase-activating protein that is regulated through its PH domain and by recruitment to the membrane. The protein accelerates hydrolysis of guanosine triphosphate to guanosine diphosphate to repress Rac activity. Knock-out of Arhgap15 function demonstrates that this gene is required to regulate multiple functions in macrophages and neutrophils. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]
Expression
Broad expression in thymus adult (RPKM 1.0), cortex adult (RPKM 0.9) and 21 other tissues See more
Orthologs
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Genomic context

See Arhgap15 in Genome Data Viewer
Location:
2; 2 B
Exon count:
22
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (43638786..44285965)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (43748798..44395953)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene kynureninase Neighboring gene predicted gene, 30374 Neighboring gene predicted gene, 39804 Neighboring gene Rho GTPase activating protein 15, opposite strand Neighboring gene predicted gene, 52508 Neighboring gene predicted gene, 39805 Neighboring gene predicted gene, 39806

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (4) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of cell shape ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
rho GTPase-activating protein 15
Names
rho-type GTPase-activating protein 15

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301831.1NP_001288760.1  rho GTPase-activating protein 15 isoform 3

    See identical proteins and their annotated locations for NP_001288760.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK036520, AK040796, AL844535
    Consensus CDS
    CCDS79793.1
    UniProtKB/TrEMBL
    B1AW40
    Related
    ENSMUSP00000108443.2, ENSMUST00000112824.8
    Conserved Domains (3) summary
    cd13233
    Location:89198
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:88196
    PH; PH domain
    cl02570
    Location:285423
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
  2. NM_001301832.1NP_001288761.1  rho GTPase-activating protein 15 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternate exon in the 5' end of the transcript compared to variant 1. This causes translation initiation at a downstream AUG and results in an isoform (4) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK036520, AK040796, BF453909
    Conserved Domains (2) summary
    cd04403
    Location:150336
    RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
    cl17171
    Location:163
    PH-like; Pleckstrin homology-like domain
  3. NM_001364029.1NP_001350958.1  rho GTPase-activating protein 15 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL732320, AL844535, AL845160, AL928611, AL935152
    Conserved Domains (2) summary
    cd04403
    Location:240426
    RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
    cd13233
    Location:44153
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
  4. NM_153820.3NP_722542.2  rho GTPase-activating protein 15 isoform 1

    See identical proteins and their annotated locations for NP_722542.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AI840874, AK036520, AK040796, BC034881
    Consensus CDS
    CCDS16019.1
    UniProtKB/Swiss-Prot
    Q811M1, Q8JZY0
    Related
    ENSMUSP00000056461.7, ENSMUST00000055776.8
    Conserved Domains (3) summary
    cd04403
    Location:285471
    RhoGAP_ARHGAP27_15_12_9; RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. ...
    cd13233
    Location:89198
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    pfam00169
    Location:88196
    PH; PH domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    43638786..44285965
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162663.1XP_036018556.1  rho GTPase-activating protein 15 isoform X3

    Conserved Domains (2) summary
    cd13233
    Location:89198
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    cl02570
    Location:285387
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
  2. XM_006498402.5XP_006498465.1  rho GTPase-activating protein 15 isoform X4

    Conserved Domains (2) summary
    cd13233
    Location:89198
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
    cl02570
    Location:285404
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
  3. XM_006498398.5XP_006498461.1  rho GTPase-activating protein 15 isoform X1

    Conserved Domains (2) summary
    cd04403
    Location:262448
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:66175
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
  4. XM_006498399.5XP_006498462.1  rho GTPase-activating protein 15 isoform X2

    See identical proteins and their annotated locations for XP_006498462.1

    UniProtKB/Swiss-Prot
    Q811M1
    Conserved Domains (2) summary
    cd04403
    Location:252438
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...
    cd13233
    Location:56165
    PH_ARHGAP9-like; Beta-spectrin pleckstrin homology (PH) domain
  5. XM_006498403.3XP_006498466.1  rho GTPase-activating protein 15 isoform X5

    See identical proteins and their annotated locations for XP_006498466.1

    UniProtKB/TrEMBL
    B2X2D4
    Conserved Domains (1) summary
    cd04403
    Location:91247
    RhoGAP_ARHGAP27_15_12_9; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001025377.1: Suppressed sequence

    Description
    NM_001025377.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.