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Dock8 dedicator of cytokinesis 8 [ Mus musculus (house mouse) ]

Gene ID: 76088, updated on 8-Feb-2024

Summary

Official Symbol
Dock8provided by MGI
Official Full Name
dedicator of cytokinesis 8provided by MGI
Primary source
MGI:MGI:1921396
See related
Ensembl:ENSMUSG00000052085 AllianceGenome:MGI:1921396
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1200017A24Rik; 5830472H07Rik; A130095G14Rik
Summary
Enables guanyl-nucleotide exchange factor activity. Involved in dendritic cell migration; positive regulation of T cell migration; and positive regulation of establishment of T cell polarity. Acts upstream of or within immunological synapse formation and negative regulation of T cell apoptotic process. Located in cell leading edge. Is expressed in central nervous system; retina; and thymus primordium. Human ortholog(s) of this gene implicated in atopic dermatitis; bacterial infectious disease; hyper IgE recurrent infection syndrome 2; immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome; and viral infectious disease (multiple). Orthologous to human DOCK8 (dedicator of cytokinesis 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 25.8), spleen adult (RPKM 17.9) and 18 other tissues See more
Orthologs
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Genomic context

See Dock8 in Genome Data Viewer
Location:
19 B; 19 19.91 cM
Exon count:
52
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (24976753..25179796)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (24999321..25202432)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_45808 Neighboring gene forkhead box D4 Neighboring gene STARR-positive B cell enhancer mm9_chr19:25033055-25033356 Neighboring gene STARR-positive B cell enhancer ABC_E7639 Neighboring gene microRNA 3084-1 Neighboring gene STARR-positive B cell enhancer ABC_E5693 Neighboring gene Zn regulated GTPase metalloprotein activator 1 Neighboring gene STARR-seq mESC enhancer starr_45809 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:25126893-25127076 Neighboring gene STARR-positive B cell enhancer ABC_E1974 Neighboring gene NADH:ubiquinone oxidoreductase subunit B4B Neighboring gene predicted gene, 34235 Neighboring gene STARR-seq mESC enhancer starr_45812 Neighboring gene predicted gene, 34186 Neighboring gene predicted gene, 24252 Neighboring gene STARR-seq mESC enhancer starr_45817 Neighboring gene KN motif and ankyrin repeat domains 1 Neighboring gene STARR-seq mESC enhancer starr_45819 Neighboring gene predicted gene, 34432 Neighboring gene predicted gene, 52392

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular response to chemokine ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within dendritic cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within dendritic cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dendritic cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within immunological synapse formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within memory T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of T cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of T cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of T cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of establishment of T cell polarity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of establishment of T cell polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of establishment of T cell polarity ISO
Inferred from Sequence Orthology
more info
 
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cell leading edge IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cell leading edge IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in leading edge membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
dedicator of cytokinesis protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_028785.3NP_083061.2  dedicator of cytokinesis protein 8

    See identical proteins and their annotated locations for NP_083061.2

    Status: VALIDATED

    Source sequence(s)
    AK028968, AK038285, AK050543, AK131180, DT909592
    Consensus CDS
    CCDS37943.1
    UniProtKB/Swiss-Prot
    Q6KAM7, Q6PIS0, Q7TMQ5, Q8C147, Q8CAP6, Q8K105, Q9DBQ2
    UniProtKB/TrEMBL
    B9EJ70
    Related
    ENSMUSP00000025831.7, ENSMUST00000025831.8
    Conserved Domains (3) summary
    cd08696
    Location:560740
    C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11701
    Location:16372058
    DHR2_DOCK8; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 8
    pfam11878
    Location:73164
    DUF3398; Domain of unknown function (DUF3398)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    24976753..25179796
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527436.5XP_006527499.1  dedicator of cytokinesis protein 8 isoform X2

    Conserved Domains (2) summary
    cd08696
    Location:560740
    C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    pfam11878
    Location:56166
    DUF3398; Domain of unknown function (DUF3398)
  2. XM_011247397.4XP_011245699.1  dedicator of cytokinesis protein 8 isoform X1

    See identical proteins and their annotated locations for XP_011245699.1

    UniProtKB/TrEMBL
    B9EJ70
    Conserved Domains (3) summary
    cd08696
    Location:492672
    C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11701
    Location:15691990
    DHR2_DOCK8; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 8
    pfam11878
    Location:198
    DUF3398; Domain of unknown function (DUF3398)
  3. XM_006527435.3XP_006527498.1  dedicator of cytokinesis protein 8 isoform X1

    See identical proteins and their annotated locations for XP_006527498.1

    UniProtKB/TrEMBL
    B9EJ70
    Conserved Domains (3) summary
    cd08696
    Location:492672
    C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11701
    Location:15691990
    DHR2_DOCK8; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 8
    pfam11878
    Location:198
    DUF3398; Domain of unknown function (DUF3398)

RNA

  1. XR_004940182.1 RNA Sequence

  2. XR_004940183.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_175233.3: Suppressed sequence

    Description
    NM_175233.3: This RefSeq was temporarily suppressed because currently there are not sufficient data to support this transcript.