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Zc3h18 zinc finger CCCH-type containing 18 [ Mus musculus (house mouse) ]

Gene ID: 76014, updated on 5-Feb-2023

Summary

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Official Symbol
Zc3h18provided by MGI
Official Full Name
zinc finger CCCH-type containing 18provided by MGI
Primary source
MGI:MGI:1923264
See related
Ensembl:ENSMUSG00000017478 AllianceGenome:MGI:1923264
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nhn1; 1190001B23Rik; 5830416A07Rik
Summary
Predicted to enable mRNA cap binding complex binding activity and protein-macromolecule adaptor activity. Predicted to be involved in RNA destabilization. Predicted to be located in nuclear speck. Predicted to be part of ribonucleoprotein complex. Is expressed in respiratory system cartilage; sensory organ; skeleton; and vibrissa. Orthologous to human ZC3H18 (zinc finger CCCH-type containing 18). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 22.4), limb E14.5 (RPKM 12.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Zc3h18 in Genome Data Viewer
Location:
8; 8 E1
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (123103298..123144104)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (122376564..122417365)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46056 Neighboring gene thyrotropin releasing hormone receptor 2 Neighboring gene interleukin 17C Neighboring gene cytochrome b-245, alpha polypeptide

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Apr 30. PMID 15449545
  2. Elf5-centered transcription factor hub controls trophoblast stem cell self-renewal and differentiation through stoichiometry-sensitive shifts in target gene networks. Latos PA, et al. Genes Dev, 2015 Dec 1. PMID 26584622, Free PMC Article
  3. Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells. Zhang S, et al. Sci Data, 2018 Nov 20. PMID 30457570, Free PMC Article
  4. ALS-linked loss of Cyclin-F function affects HSP90. Siebert A, et al. Life Sci Alliance, 2022 Sep 16. PMID 36114006, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (16) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables mRNA cap binding complex binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in RNA destabilization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger CCCH domain-containing protein 18
Names
conserved nuclear protein Nhn1
nuclear protein NHN1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001029993.1 → NP_001025164.1  zinc finger CCCH domain-containing protein 18 isoform a

    See identical proteins and their annotated locations for NP_001025164.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AK004428, AK017933, AK031413, BC030495, BY235998
    Consensus CDS
    CCDS22735.1
    UniProtKB/Swiss-Prot
    Q0P678
    UniProtKB/TrEMBL
    G3X8T2
    Related
    ENSMUSP00000017622.6, ENSMUST00000017622.12

  2. NM_001029994.1 → NP_001025165.1  zinc finger CCCH domain-containing protein 18 isoform b

    See identical proteins and their annotated locations for NP_001025165.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon, compared to variant 1, but maintains the reading frame. The resulting protein (isoform b) is shorter than isoform a.
    Source sequence(s)
    BC030495, BY235998, CD348551
    Consensus CDS
    CCDS22736.1
    UniProtKB/Swiss-Prot
    Q0P678, Q9CU64
    Related
    ENSMUSP00000090761.6, ENSMUST00000093073.12
    Conserved Domains (1) summary
    smart00356
    Location:211 → 239
    ZnF_C3H1; zinc finger

  3. NM_001310650.1 → NP_001297579.1  zinc finger CCCH domain-containing protein 18 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. It encodes isoform c, which is shorter than isoform a.
    Source sequence(s)
    AK159881, BC094330, BM900035, BY125794, BY235998
    Consensus CDS
    CCDS80941.1
    UniProtKB/Swiss-Prot
    Q0P678
    UniProtKB/TrEMBL
    H3BIW0
    Related
    ENSMUSP00000134743.2, ENSMUST00000176629.8

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    123103298..123144104
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243834.2 → XP_030099694.1  zinc finger CCCH domain-containing protein 18 isoform X5

    Conserved Domains (1) summary
    pfam18044
    Location:218 → 239
    zf-CCCH_4; CCCH-type zinc finger

  2. XM_006531470.4 → XP_006531533.1  zinc finger CCCH domain-containing protein 18 isoform X3

    Conserved Domains (2) summary
    pfam18044
    Location:254 → 275
    zf-CCCH_4; CCCH-type zinc finger
    NF000535
    Location:21 → 165
    MSCRAMM_SdrC; MSCRAMM family adhesin SdrC

  3. XM_006531469.4 → XP_006531532.1  zinc finger CCCH domain-containing protein 18 isoform X1

    Conserved Domains (2) summary
    NF000535
    Location:21 → 165
    MSCRAMM_SdrC; MSCRAMM family adhesin SdrC
    cl39030
    Location:254 → 299
    zf_CCCH_4; Zinc finger domain

  4. XM_011248538.2 → XP_011246840.1  zinc finger CCCH domain-containing protein 18 isoform X2

    Conserved Domains (2) summary
    NF000535
    Location:21 → 165
    MSCRAMM_SdrC; MSCRAMM family adhesin SdrC
    cl39030
    Location:254 → 299
    zf_CCCH_4; Zinc finger domain

  5. XM_036154364.1 → XP_036010257.1  zinc finger CCCH domain-containing protein 18 isoform X4

    Conserved Domains (2) summary
    NF000535
    Location:21 → 165
    MSCRAMM_SdrC; MSCRAMM family adhesin SdrC
    pfam18044
    Location:254 → 275
    zf-CCCH_4; CCCH-type zinc finger

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_024268.1: Suppressed sequence

    Description
    NM_024268.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0P678.1 GenPept UniProtKB/Swiss-Prot:Q0P678

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