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ZNF41 zinc finger protein 41 [ Homo sapiens (human) ]

Gene ID: 7592, updated on 23-Nov-2021

Summary

Official Symbol
ZNF41provided by HGNC
Official Full Name
zinc finger protein 41provided by HGNC
Primary source
HGNC:HGNC:13107
See related
Ensembl:ENSG00000147124 MIM:314995
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRX89
Summary
This gene encodes a protein that contains KRAB-A and KRAB-B domains multiple zinc finger DNA binding motifs and finger linking regions characteristic of the Kruppel family. An initial study suggested that this gene may be associated with X-linked cognitive disability, but a later study has called this finding into question (PMID:23871722).[provided by RefSeq, Apr 2016]
Expression
Ubiquitous expression in thyroid (RPKM 3.3), heart (RPKM 2.6) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF41 in Genome Data Viewer
Location:
Xp11.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (47444691..47485934, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (47304577..47342621, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene zinc finger protein 157 Neighboring gene UBX domain protein 4 pseudogene Neighboring gene nucleophosmin 1 pseudogene 49 Neighboring gene long intergenic non-protein coding RNA 1560 Neighboring gene NUS1 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 4668 Neighboring gene A-Raf proto-oncogene, serine/threonine kinase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2012-10-24)

ClinGen Genome Curation Page
Haploinsufficency

Little evidence for dosage pathogenicity (Last evaluated 2012-10-24)

ClinGen Genome Curation PagePubMed

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC8941

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008238.1 RefSeqGene

    Range
    5001..42769
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001324139.2NP_001311068.1  zinc finger protein 41 isoform b

    Status: REVIEWED

    Source sequence(s)
    AK294858, AL590223, DA127531
    UniProtKB/Swiss-Prot
    P51814
    Conserved Domains (3) summary
    COG5048
    Location:218640
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:327347
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:508532
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001324140.2NP_001311069.1  zinc finger protein 41 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL590223, BQ053634, DA127531
    Consensus CDS
    CCDS14279.1
    UniProtKB/Swiss-Prot
    P51814
    UniProtKB/TrEMBL
    A0A024R1C4
    Conserved Domains (3) summary
    smart00349
    Location:2787
    KRAB; krueppel associated box
    COG5048
    Location:304726
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:413433
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. NM_001324141.2NP_001311070.1  zinc finger protein 41 isoform b

    Status: REVIEWED

    Source sequence(s)
    AL590223, DA127531, DA567652
    UniProtKB/Swiss-Prot
    P51814
    Conserved Domains (3) summary
    COG5048
    Location:218640
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:327347
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:508532
    zf-H2C2_2; Zinc-finger double domain
  4. NM_001324142.2NP_001311071.1  zinc finger protein 41 isoform c

    Status: REVIEWED

    Source sequence(s)
    AL590223, AL590283, Z84466
    UniProtKB/Swiss-Prot
    P51814
    Conserved Domains (5) summary
    smart00349
    Location:2989
    KRAB; krueppel associated box
    COG5048
    Location:306728
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:415435
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:2968
    KRAB; KRAB box
    pfam13465
    Location:596620
    zf-H2C2_2; Zinc-finger double domain
  5. NM_001324143.2NP_001311072.1  zinc finger protein 41 isoform b

    Status: REVIEWED

    Source sequence(s)
    AL590223, DA783869
    UniProtKB/Swiss-Prot
    P51814
    Conserved Domains (3) summary
    COG5048
    Location:218640
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:327347
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:508532
    zf-H2C2_2; Zinc-finger double domain
  6. NM_001324144.2NP_001311073.1  zinc finger protein 41 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL590223, AL590283, Z84466
    Consensus CDS
    CCDS14279.1
    UniProtKB/Swiss-Prot
    P51814
    UniProtKB/TrEMBL
    A0A024R1C4
    Related
    ENSP00000508254.1, ENST00000684689.1
    Conserved Domains (3) summary
    smart00349
    Location:2787
    KRAB; krueppel associated box
    COG5048
    Location:304726
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:413433
    ZF_C2H2; C2H2 Zn finger [structural motif]
  7. NM_001324145.2NP_001311074.1  zinc finger protein 41 isoform b

    Status: REVIEWED

    Source sequence(s)
    AL590223, AL590283, Z84466
    UniProtKB/Swiss-Prot
    P51814
    Conserved Domains (3) summary
    COG5048
    Location:218640
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:327347
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:508532
    zf-H2C2_2; Zinc-finger double domain
  8. NM_001324147.2NP_001311076.1  zinc finger protein 41 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL590223, AL590283, Z84466
    Consensus CDS
    CCDS14279.1
    UniProtKB/Swiss-Prot
    P51814
    UniProtKB/TrEMBL
    A0A024R1C4
    Conserved Domains (3) summary
    smart00349
    Location:2787
    KRAB; krueppel associated box
    COG5048
    Location:304726
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:413433
    ZF_C2H2; C2H2 Zn finger [structural motif]
  9. NM_001324148.2NP_001311077.1  zinc finger protein 41 isoform c

    Status: REVIEWED

    Source sequence(s)
    AL590223, AL590283, Z84466
    UniProtKB/Swiss-Prot
    P51814
    Conserved Domains (5) summary
    smart00349
    Location:2989
    KRAB; krueppel associated box
    COG5048
    Location:306728
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:415435
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:2968
    KRAB; KRAB box
    pfam13465
    Location:596620
    zf-H2C2_2; Zinc-finger double domain
  10. NM_001324149.2NP_001311078.1  zinc finger protein 41 isoform b

    Status: REVIEWED

    Source sequence(s)
    AL590223, AL590283, Z84466
    UniProtKB/Swiss-Prot
    P51814
    Conserved Domains (3) summary
    COG5048
    Location:218640
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:327347
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:508532
    zf-H2C2_2; Zinc-finger double domain
  11. NM_001324150.2NP_001311079.1  zinc finger protein 41 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL590223, AL590283, Z84466
    Consensus CDS
    CCDS14279.1
    UniProtKB/Swiss-Prot
    P51814
    UniProtKB/TrEMBL
    A0A024R1C4
    Conserved Domains (3) summary
    smart00349
    Location:2787
    KRAB; krueppel associated box
    COG5048
    Location:304726
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:413433
    ZF_C2H2; C2H2 Zn finger [structural motif]
  12. NM_001324151.2NP_001311080.1  zinc finger protein 41 isoform d

    Status: REVIEWED

    Source sequence(s)
    AL590223, AL590283, Z84466
    UniProtKB/Swiss-Prot
    P51814
    Conserved Domains (5) summary
    smart00349
    Location:3797
    KRAB; krueppel associated box
    COG5048
    Location:314736
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:423443
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:3776
    KRAB; KRAB box
    pfam13465
    Location:604628
    zf-H2C2_2; Zinc-finger double domain
  13. NM_001324152.2NP_001311081.1  zinc finger protein 41 isoform b

    Status: REVIEWED

    Source sequence(s)
    AL590223, AL590283, Z84466
    UniProtKB/Swiss-Prot
    P51814
    Conserved Domains (3) summary
    COG5048
    Location:218640
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:327347
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:508532
    zf-H2C2_2; Zinc-finger double domain
  14. NM_001324153.2NP_001311082.1  zinc finger protein 41 isoform d

    Status: REVIEWED

    Source sequence(s)
    AL590223, AL590283, Z84466
    UniProtKB/Swiss-Prot
    P51814
    Conserved Domains (5) summary
    smart00349
    Location:3797
    KRAB; krueppel associated box
    COG5048
    Location:314736
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:423443
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:3776
    KRAB; KRAB box
    pfam13465
    Location:604628
    zf-H2C2_2; Zinc-finger double domain
  15. NM_001324154.1NP_001311083.1  zinc finger protein 41 isoform e

    Status: REVIEWED

    Source sequence(s)
    AJ010020, AL590223, BC015023
    UniProtKB/Swiss-Prot
    P51814
    Conserved Domains (6) summary
    smart00349
    Location:61121
    KRAB; krueppel associated box
    COG5048
    Location:338760
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:447467
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:669691
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:61100
    KRAB; KRAB box
    pfam13465
    Location:628652
    zf-H2C2_2; Zinc-finger double domain
  16. NM_001324155.1NP_001311084.1  zinc finger protein 41 isoform f

    Status: REVIEWED

    Source sequence(s)
    AJ010020, AJ010021, AL590223, BC015023
    UniProtKB/Swiss-Prot
    P51814
    Conserved Domains (6) summary
    smart00349
    Location:69129
    KRAB; krueppel associated box
    COG5048
    Location:346768
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:455475
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:677699
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:69108
    KRAB; KRAB box
    pfam13465
    Location:636660
    zf-H2C2_2; Zinc-finger double domain
  17. NM_001324156.1NP_001311085.1  zinc finger protein 41 isoform g

    Status: REVIEWED

    Source sequence(s)
    AJ010022, AL590223, BC015023
    UniProtKB/Swiss-Prot
    P51814
  18. NM_001324157.1NP_001311086.1  zinc finger protein 41 isoform h

    Status: REVIEWED

    Source sequence(s)
    AJ010023, AL590223, BC015023
    UniProtKB/Swiss-Prot
    P51814
  19. NM_007130.4NP_009061.1  zinc finger protein 41 isoform a

    See identical proteins and their annotated locations for NP_009061.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript.
    Source sequence(s)
    AK290021, AL590223, BC015023
    Consensus CDS
    CCDS14279.1
    UniProtKB/Swiss-Prot
    P51814
    UniProtKB/TrEMBL
    A0A024R1C4
    Related
    ENSP00000315173.7, ENST00000313116.11
    Conserved Domains (3) summary
    smart00349
    Location:2787
    KRAB; krueppel associated box
    COG5048
    Location:304726
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:413433
    ZF_C2H2; C2H2 Zn finger [structural motif]
  20. NM_153380.3NP_700359.1  zinc finger protein 41 isoform a

    See identical proteins and their annotated locations for NP_700359.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1.
    Source sequence(s)
    AL590223, BC015023
    Consensus CDS
    CCDS14279.1
    UniProtKB/Swiss-Prot
    P51814
    UniProtKB/TrEMBL
    A0A024R1C4
    Related
    ENSP00000366265.4, ENST00000377065.8
    Conserved Domains (3) summary
    smart00349
    Location:2787
    KRAB; krueppel associated box
    COG5048
    Location:304726
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:413433
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    47444691..47485934 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029814.2XP_016885303.1  zinc finger protein 41 isoform X1

    UniProtKB/Swiss-Prot
    P51814
    Conserved Domains (6) summary
    smart00349
    Location:61121
    KRAB; krueppel associated box
    COG5048
    Location:338760
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:447467
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:669691
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:61100
    KRAB; KRAB box
    pfam13465
    Location:628652
    zf-H2C2_2; Zinc-finger double domain
  2. XM_017029811.2XP_016885300.1  zinc finger protein 41 isoform X1

    UniProtKB/Swiss-Prot
    P51814
    Conserved Domains (6) summary
    smart00349
    Location:61121
    KRAB; krueppel associated box
    COG5048
    Location:338760
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:447467
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:669691
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:61100
    KRAB; KRAB box
    pfam13465
    Location:628652
    zf-H2C2_2; Zinc-finger double domain
  3. XM_017029810.2XP_016885299.1  zinc finger protein 41 isoform X1

    UniProtKB/Swiss-Prot
    P51814
    Conserved Domains (6) summary
    smart00349
    Location:61121
    KRAB; krueppel associated box
    COG5048
    Location:338760
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:447467
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:669691
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:61100
    KRAB; KRAB box
    pfam13465
    Location:628652
    zf-H2C2_2; Zinc-finger double domain
  4. XM_006724550.3XP_006724613.1  zinc finger protein 41 isoform X1

    See identical proteins and their annotated locations for XP_006724613.1

    UniProtKB/Swiss-Prot
    P51814
    Conserved Domains (6) summary
    smart00349
    Location:61121
    KRAB; krueppel associated box
    COG5048
    Location:338760
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:447467
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:669691
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:61100
    KRAB; KRAB box
    pfam13465
    Location:628652
    zf-H2C2_2; Zinc-finger double domain
  5. XM_017029815.1XP_016885304.1  zinc finger protein 41 isoform X1

    UniProtKB/Swiss-Prot
    P51814
    Conserved Domains (6) summary
    smart00349
    Location:61121
    KRAB; krueppel associated box
    COG5048
    Location:338760
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:447467
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:669691
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:61100
    KRAB; KRAB box
    pfam13465
    Location:628652
    zf-H2C2_2; Zinc-finger double domain
  6. XM_006724555.3XP_006724618.1  zinc finger protein 41 isoform X2

    See identical proteins and their annotated locations for XP_006724618.1

    UniProtKB/Swiss-Prot
    P51814
    Conserved Domains (5) summary
    smart00349
    Location:3797
    KRAB; krueppel associated box
    COG5048
    Location:314736
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:423443
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:3776
    KRAB; KRAB box
    pfam13465
    Location:604628
    zf-H2C2_2; Zinc-finger double domain
  7. XM_017029812.1XP_016885301.1  zinc finger protein 41 isoform X1

    UniProtKB/Swiss-Prot
    P51814
    Conserved Domains (6) summary
    smart00349
    Location:61121
    KRAB; krueppel associated box
    COG5048
    Location:338760
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:447467
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:669691
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:61100
    KRAB; KRAB box
    pfam13465
    Location:628652
    zf-H2C2_2; Zinc-finger double domain
  8. XM_017029817.1XP_016885306.1  zinc finger protein 41 isoform X3

    UniProtKB/Swiss-Prot
    P51814
    UniProtKB/TrEMBL
    A0A024R1C4
    Conserved Domains (3) summary
    smart00349
    Location:2787
    KRAB; krueppel associated box
    COG5048
    Location:304726
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:413433
    ZF_C2H2; C2H2 Zn finger [structural motif]
  9. XM_017029816.1XP_016885305.1  zinc finger protein 41 isoform X2

    UniProtKB/Swiss-Prot
    P51814
    Conserved Domains (5) summary
    smart00349
    Location:3797
    KRAB; krueppel associated box
    COG5048
    Location:314736
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:423443
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:3776
    KRAB; KRAB box
    pfam13465
    Location:604628
    zf-H2C2_2; Zinc-finger double domain
  10. XM_017029813.1XP_016885302.1  zinc finger protein 41 isoform X1

    UniProtKB/Swiss-Prot
    P51814
    Conserved Domains (6) summary
    smart00349
    Location:61121
    KRAB; krueppel associated box
    COG5048
    Location:338760
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:447467
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:669691
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:61100
    KRAB; KRAB box
    pfam13465
    Location:628652
    zf-H2C2_2; Zinc-finger double domain
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