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Hormad2 HORMA domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 75828, updated on 12-May-2024

Summary

Official Symbol
Hormad2provided by MGI
Official Full Name
HORMA domain containing 2provided by MGI
Primary source
MGI:MGI:1923078
See related
Ensembl:ENSMUSG00000020419 AllianceGenome:MGI:1923078
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930529M09Rik
Summary
Involved in meiotic sister chromatid cohesion. Acts upstream of or within meiotic cell cycle. Located in synaptonemal complex. Is expressed in ovary; spermatocyte; and testis. Orthologous to human HORMAD2 (HORMA domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 2.8) and liver E14 (RPKM 0.1) See more
Orthologs
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Genomic context

See Hormad2 in Genome Data Viewer
Location:
11 A1; 11 2.94 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (4295801..4391215, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (4345801..4441198, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 11958 Neighboring gene predicted gene, 53662 Neighboring gene predicted gene, 24803 Neighboring gene STARR-seq mESC enhancer starr_28383 Neighboring gene STARR-seq mESC enhancer starr_28385 Neighboring gene STARR-positive B cell enhancer ABC_E5204 Neighboring gene STARR-seq mESC enhancer starr_28386 Neighboring gene myotubularin related protein 3 Neighboring gene STARR-seq mESC enhancer starr_28391 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E728 Neighboring gene predicted gene 11961

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (4)  1 citation

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in meiotic cell cycle IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in meiotic sister chromatid cohesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in synaptonemal complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
HORMA domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417965.1NP_001404894.1  HORMA domain-containing protein 2

    Status: VALIDATED

    Source sequence(s)
    AL645910, AL731658
    UniProtKB/Swiss-Prot
    B7ZMW2, Q5SQP1, Q9D507
  2. NM_029458.2NP_083734.1  HORMA domain-containing protein 2

    See identical proteins and their annotated locations for NP_083734.1

    Status: VALIDATED

    Source sequence(s)
    AL645910, AL731658
    Consensus CDS
    CCDS36096.1
    UniProtKB/Swiss-Prot
    B7ZMW2, Q5SQP1, Q9D507
    Related
    ENSMUSP00000105575.2, ENSMUST00000109949.8
    Conserved Domains (1) summary
    pfam02301
    Location:31226
    HORMA; HORMA domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    4295801..4391215 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011243780.3XP_011242082.1  HORMA domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011242082.1

    UniProtKB/Swiss-Prot
    B7ZMW2, Q5SQP1, Q9D507
    Conserved Domains (1) summary
    pfam02301
    Location:31226
    HORMA; HORMA domain
  2. XM_011243777.3XP_011242079.1  HORMA domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011242079.1

    UniProtKB/Swiss-Prot
    B7ZMW2, Q5SQP1, Q9D507
    Conserved Domains (1) summary
    pfam02301
    Location:31226
    HORMA; HORMA domain
  3. XM_011243781.1XP_011242083.1  HORMA domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011242083.1

    UniProtKB/Swiss-Prot
    B7ZMW2, Q5SQP1, Q9D507
    Related
    ENSMUSP00000105574.2, ENSMUST00000109948.8
    Conserved Domains (1) summary
    pfam02301
    Location:31226
    HORMA; HORMA domain
  4. XM_017314818.1XP_017170307.1  HORMA domain-containing protein 2 isoform X3

    Conserved Domains (1) summary
    pfam02301
    Location:291
    HORMA; HORMA domain
  5. XM_017314817.2XP_017170306.1  HORMA domain-containing protein 2 isoform X2

    Conserved Domains (1) summary
    pfam02301
    Location:31226
    HORMA; HORMA domain