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ZNF33A zinc finger protein 33A [ Homo sapiens (human) ]

Gene ID: 7581, updated on 13-Mar-2020

Summary

Official Symbol
ZNF33Aprovided by HGNC
Official Full Name
zinc finger protein 33Aprovided by HGNC
Primary source
HGNC:HGNC:13096
See related
Ensembl:ENSG00000189180 MIM:194521
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KOX2; KOX5; KOX31; NF11A; ZNF11; ZNF33; ZZAPK; ZNF11A
Expression
Ubiquitous expression in thyroid (RPKM 6.2), prostate (RPKM 5.2) and 25 other tissues See more
Orthologs

Genomic context

See ZNF33A in Genome Data Viewer
Location:
10p11.1
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (38010483..38067834)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (38299578..38353946)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene zinc finger protein 25 Neighboring gene ZNF25 divergent transcript Neighboring gene RNA, U6 small nuclear 795, pseudogene Neighboring gene eukaryotic translation initiation factor 3 subunit L pseudogene 3 Neighboring gene FXYD domain containing ion transport regulator 6 pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23404, KIAA0065

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
nucleus NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 33A
Names
brain my041 protein
zinc finger and ZAK-associated protein with KRAB domain
zinc finger protein 11A
zinc finger protein 33a (KOX 31)
zinc finger protein KOX31

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278170.2NP_001265099.1  zinc finger protein 33A isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks the exon containing the translation start site and uses an alternate in-frame splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (c) has a longer and distinct N-terminus and lacks an aa near the C-terminus compared to isoform a.
    Source sequence(s)
    AK303445, CD679489, D31763
    Consensus CDS
    CCDS60514.1
    UniProtKB/Swiss-Prot
    Q06730
    Related
    ENSP00000485869.1, ENST00000628825.2
    Conserved Domains (5) summary
    smart00349
    Location:1978
    KRAB; krueppel associated box
    COG5048
    Location:429805
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:365385
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:1958
    KRAB; KRAB box
    pfam13465
    Location:377402
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001278171.2NP_001265100.1  zinc finger protein 33A isoform d

    See identical proteins and their annotated locations for NP_001265100.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate exon before the last exon compared to variant 1. This difference causes translation initiation at a downstream AUG and results in an isoform (d) with a shorter N-terminus compared to isoform a. Variants 4, 6, and 10-14 all encode the same isoform (d).
    Source sequence(s)
    AK292844, AL161931, AL712670, CD679489, D31763, DB235703
    Consensus CDS
    CCDS73089.1
    UniProtKB/Swiss-Prot
    Q06730
    UniProtKB/TrEMBL
    A0A0A0MRS1
    Conserved Domains (3) summary
    COG5048
    Location:217562
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:247267
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:259284
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001278173.1NP_001265102.1  zinc finger protein 33A isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains an alternate exon in the 5' end compared to variant 1. The resulting isoform (e) initiates translation in the alternate exon, so isoform e has a longer and distinct N-terminus compared to isoform a.
    Source sequence(s)
    CD679489, D31763, DB234051, DB235703
    Consensus CDS
    CCDS73088.1
    UniProtKB/Swiss-Prot
    Q06730
    UniProtKB/TrEMBL
    A0A0A0MR11
    Related
    ENSP00000304268.10, ENST00000307441.13
    Conserved Domains (5) summary
    smart00349
    Location:3089
    KRAB; krueppel associated box
    COG5048
    Location:347692
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:377397
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:3069
    KRAB; KRAB box
    pfam13465
    Location:389414
    zf-H2C2_2; Zinc-finger double domain
  4. NM_001278174.2NP_001265103.1  zinc finger protein 33A isoform d

    See identical proteins and their annotated locations for NP_001265103.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) contains an alternate exon before the last exon compared to variant 1. This difference causes translation initiation at a downstream AUG and results in an isoform (d) with a shorter N-terminus compared to isoform a. Variants 4, 6, and 10-14 all encode the same isoform (d).
    Source sequence(s)
    AL161931, CD679489, D31763, DA276183, DB235703
    Consensus CDS
    CCDS73089.1
    UniProtKB/Swiss-Prot
    Q06730
    UniProtKB/TrEMBL
    A0A0A0MRS1
    Conserved Domains (3) summary
    COG5048
    Location:217562
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:247267
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:259284
    zf-H2C2_2; Zinc-finger double domain
  5. NM_001278175.2NP_001265104.1  zinc finger protein 33A isoform f

    See identical proteins and their annotated locations for NP_001265104.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) contains an alternate exon before the last exon compared to variant 1. Translation of this variant begins in the alternate exon, so the resulting isoform (f) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AL161931, CD679489, D31763, DB134021, DB235703
    UniProtKB/Swiss-Prot
    Q06730
    Conserved Domains (3) summary
    COG5048
    Location:251596
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:281301
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:293318
    zf-H2C2_2; Zinc-finger double domain
  6. NM_001278176.2NP_001265105.1  zinc finger protein 33A isoform g

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) contains an alternate exon before the last exon compared to variant 1. Translation of this variant begins at a downstream AUG compared to variant 1, so the resulting isoform (g) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AI300433, AL161931, CD679489, D31763, DB235703
    UniProtKB/Swiss-Prot
    Q06730
    Conserved Domains (3) summary
    COG5048
    Location:286631
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:316336
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:328353
    zf-H2C2_2; Zinc-finger double domain
  7. NM_001278177.2NP_001265106.1  zinc finger protein 33A isoform h

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) uses an alternate splice junction at the 5' end of a coding exon compared to variant 1, that causes a frameshift. The resulting isoform (h) has a longer and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AL161931, BF435065, CD679489, D31763, DB235703
    UniProtKB/Swiss-Prot
    Q06730
    Conserved Domains (5) summary
    smart00349
    Location:3392
    KRAB; krueppel associated box
    COG5048
    Location:444820
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:380400
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:3372
    KRAB; KRAB box
    pfam13465
    Location:392417
    zf-H2C2_2; Zinc-finger double domain
  8. NM_001278178.1NP_001265107.1  zinc finger protein 33A isoform d

    See identical proteins and their annotated locations for NP_001265107.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) uses an alternate splice junction at the 3' end of a coding exon compared to variant 1. This difference causes translation initiation at a downstream AUG and results in an isoform (d) with a shorter N-terminus compared to isoform a. Variants 4, 6, and 10-14 all encode the same isoform (d).
    Source sequence(s)
    CD679489, D31763, DA757208, DB235703
    Consensus CDS
    CCDS73089.1
    UniProtKB/Swiss-Prot
    Q06730
    UniProtKB/TrEMBL
    A0A0A0MRS1
    Related
    ENSP00000363747.4, ENST00000374618.7
    Conserved Domains (3) summary
    COG5048
    Location:217562
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:247267
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:259284
    zf-H2C2_2; Zinc-finger double domain
  9. NM_001278179.2NP_001265108.1  zinc finger protein 33A isoform d

    See identical proteins and their annotated locations for NP_001265108.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) contains an alternate exon before the last exon and uses an alternate splice junction at the 5' end of the last exon compared to variant 1. These differences cause translation initiation at a downstream AUG and results in an isoform (d) with a shorter N-terminus compared to isoform a. Variants 4, 6, and 10-14 all encode the same isoform (d).
    Source sequence(s)
    AL712670, CD679489, D31763, DB235703
    Consensus CDS
    CCDS73089.1
    UniProtKB/Swiss-Prot
    Q06730
    UniProtKB/TrEMBL
    A0A0A0MRS1
    Conserved Domains (3) summary
    COG5048
    Location:217562
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:247267
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:259284
    zf-H2C2_2; Zinc-finger double domain
  10. NM_001324175.2NP_001311104.1  zinc finger protein 33A isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12), as well as variants 4, 6, 10-11, and 13-14, encodes isoform d.
    Source sequence(s)
    AL117337, AL161931
    Consensus CDS
    CCDS73089.1
    UniProtKB/TrEMBL
    A0A0A0MRS1
    Conserved Domains (3) summary
    COG5048
    Location:217562
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:247267
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:259284
    zf-H2C2_2; Zinc-finger double domain
  11. NM_001324176.2NP_001311105.1  zinc finger protein 33A isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13), as well as variants 4, 6, 10-12, and 14, encodes isoform d.
    Source sequence(s)
    AL117337, AL161931
    Consensus CDS
    CCDS73089.1
    UniProtKB/TrEMBL
    A0A0A0MRS1
    Conserved Domains (3) summary
    COG5048
    Location:217562
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:247267
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:259284
    zf-H2C2_2; Zinc-finger double domain
  12. NM_001324177.2NP_001311106.1  zinc finger protein 33A isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14), as well as variants 4, 6, and 10-13, encodes isoform d.
    Source sequence(s)
    AL117337, AL161931
    Consensus CDS
    CCDS73089.1
    UniProtKB/TrEMBL
    A0A0A0MRS1
    Conserved Domains (3) summary
    COG5048
    Location:217562
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:247267
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:259284
    zf-H2C2_2; Zinc-finger double domain
  13. NM_001324178.2NP_001311107.1  zinc finger protein 33A isoform i

    Status: VALIDATED

    Source sequence(s)
    AL117337, AL161931
  14. NM_006954.2NP_008885.1  zinc finger protein 33A isoform a

    See identical proteins and their annotated locations for NP_008885.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform a.
    Source sequence(s)
    AL161931, CD679489, D31763, DB235703
    Consensus CDS
    CCDS44372.1
    UniProtKB/Swiss-Prot
    Q06730
    Related
    ENSP00000402467.3, ENST00000432900.7
    Conserved Domains (5) summary
    smart00349
    Location:1271
    KRAB; krueppel associated box
    COG5048
    Location:423799
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:359379
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:1251
    KRAB; KRAB box
    pfam13465
    Location:371396
    zf-H2C2_2; Zinc-finger double domain
  15. NM_006974.3NP_008905.1  zinc finger protein 33A isoform b

    See identical proteins and their annotated locations for NP_008905.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is 1 aa shorter compared to isoform a.
    Source sequence(s)
    CD679489, D31763, DB235703
    Consensus CDS
    CCDS31182.1
    UniProtKB/Swiss-Prot
    Q06730
    Related
    ENSP00000387713.2, ENST00000458705.6
    Conserved Domains (5) summary
    smart00349
    Location:1271
    KRAB; krueppel associated box
    COG5048
    Location:328673
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:358378
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:1251
    KRAB; KRAB box
    pfam13465
    Location:370395
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_136709.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL117337, AL161931
  2. NR_136710.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL117337, AL161931

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    38010483..38067834
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011519650.2XP_011517952.1  zinc finger protein 33A isoform X1

    See identical proteins and their annotated locations for XP_011517952.1

    UniProtKB/Swiss-Prot
    Q06730
    Conserved Domains (5) summary
    smart00349
    Location:1271
    KRAB; krueppel associated box
    COG5048
    Location:423799
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:359379
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:1251
    KRAB; KRAB box
    pfam13465
    Location:371396
    zf-H2C2_2; Zinc-finger double domain
  2. XM_011519651.2XP_011517953.1  zinc finger protein 33A isoform X2

    See identical proteins and their annotated locations for XP_011517953.1

    UniProtKB/Swiss-Prot
    Q06730
    Conserved Domains (5) summary
    smart00349
    Location:1271
    KRAB; krueppel associated box
    COG5048
    Location:328673
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:358378
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:1251
    KRAB; KRAB box
    pfam13465
    Location:370395
    zf-H2C2_2; Zinc-finger double domain
  3. XM_017016617.1XP_016872106.1  zinc finger protein 33A isoform X3

  4. XM_011519653.2XP_011517955.1  zinc finger protein 33A isoform X4

    See identical proteins and their annotated locations for XP_011517955.1

    Conserved Domains (3) summary
    COG5048
    Location:251596
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:281301
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:293318
    zf-H2C2_2; Zinc-finger double domain
  5. XM_011519654.2XP_011517956.1  zinc finger protein 33A isoform X5

    Conserved Domains (3) summary
    COG5048
    Location:250595
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:280300
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:292317
    zf-H2C2_2; Zinc-finger double domain
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