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Nln neurolysin (metallopeptidase M3 family) [ Mus musculus (house mouse) ]

Gene ID: 75805, updated on 26-Sep-2022

Summary

Official Symbol
Nlnprovided by MGI
Official Full Name
neurolysin (metallopeptidase M3 family)provided by MGI
Primary source
MGI:MGI:1923055
See related
Ensembl:ENSMUSG00000021710 AllianceGenome:MGI:1923055
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4930472G13Rik
Summary
Enables peptidase activity and peptide binding activity. Acts upstream of or within regulation of gluconeogenesis and regulation of skeletal muscle fiber differentiation. Located in plasma membrane. Orthologous to human NLN (neurolysin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 12.4), whole brain E14.5 (RPKM 7.3) and 28 other tissues See more
Orthologs
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Genomic context

See Nln in Genome Data Viewer
Location:
13; 13 D1
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (104159558..104246170, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (104023050..104109673, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene splicing regulatory glutamine/lysine-rich protein 1 Neighboring gene predicted gene, 52054 Neighboring gene Erbb2 interacting protein Neighboring gene RIKEN cDNA D130037M23 gene Neighboring gene predicted gene, 30967 Neighboring gene small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta Neighboring gene trafficking protein particle complex 13 Neighboring gene shieldin complex subunit 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metalloendopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables oligopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables peptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables peptide binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in peptide catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in peptide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of gluconeogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of skeletal muscle fiber differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in mitochondrial intermembrane space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrial intermembrane space ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
neurolysin, mitochondrial
Names
MEP
microsomal endopeptidase
mitochondrial oligopeptidase M
neurotensin endopeptidase
NP_083723.1
XP_011243001.1
XP_011243002.1
XP_011243003.1
XP_030103312.1
XP_036014106.1
XP_036014107.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029447.2NP_083723.1  neurolysin, mitochondrial precursor

    See identical proteins and their annotated locations for NP_083723.1

    Status: PROVISIONAL

    Source sequence(s)
    AK079090
    Consensus CDS
    CCDS36772.1
    UniProtKB/Swiss-Prot
    Q8R3F4, Q91YP2
    Related
    ENSMUSP00000104938.4, ENSMUST00000109315.5
    Conserved Domains (2) summary
    cd06455
    Location:60699
    M3A_TOP; Peptidase M3 Thimet oligopeptidase (TOP) also includes neurolysin
    COG0339
    Location:54703
    Dcp; Zn-dependent oligopeptidase [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    104159558..104246170 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011244699.3XP_011243001.1  neurolysin, mitochondrial isoform X1

    Conserved Domains (1) summary
    cd09605
    Location:58741
    M3A; Peptidase M3A family includes thimet oligopeptidase, dipeptidyl carboxypeptidase and mitochondrial intermediate peptidase
  2. XM_011244700.2XP_011243002.1  neurolysin, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_011243002.1

    Conserved Domains (1) summary
    cd09605
    Location:35718
    M3A; Peptidase M3A family includes thimet oligopeptidase, dipeptidyl carboxypeptidase and mitochondrial intermediate peptidase
  3. XM_011244701.3XP_011243003.1  neurolysin, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_011243003.1

    Conserved Domains (1) summary
    cd09605
    Location:35718
    M3A; Peptidase M3A family includes thimet oligopeptidase, dipeptidyl carboxypeptidase and mitochondrial intermediate peptidase
  4. XM_036158213.1XP_036014106.1  neurolysin, mitochondrial isoform X2

    Conserved Domains (1) summary
    cd09605
    Location:35718
    M3A; Peptidase M3A family includes thimet oligopeptidase, dipeptidyl carboxypeptidase and mitochondrial intermediate peptidase
  5. XM_036158214.1XP_036014107.1  neurolysin, mitochondrial isoform X3

    Conserved Domains (1) summary
    cd09605
    Location:35676
    M3A; Peptidase M3A family includes thimet oligopeptidase, dipeptidyl carboxypeptidase and mitochondrial intermediate peptidase
  6. XM_030247452.2XP_030103312.1  neurolysin, mitochondrial isoform X3

    Conserved Domains (1) summary
    cd09605
    Location:35676
    M3A; Peptidase M3A family includes thimet oligopeptidase, dipeptidyl carboxypeptidase and mitochondrial intermediate peptidase

RNA

  1. XR_873797.4 RNA Sequence