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Ckap5 cytoskeleton associated protein 5 [ Mus musculus (house mouse) ]

Gene ID: 75786, updated on 12-May-2024

Summary

Official Symbol
Ckap5provided by MGI
Official Full Name
cytoskeleton associated protein 5provided by MGI
Primary source
MGI:MGI:1923036
See related
Ensembl:ENSMUSG00000040549 AllianceGenome:MGI:1923036
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0097; 3110043H24Rik; 4930432B04Rik; D730027C18Rik
Summary
Predicted to enable microtubule binding activity; microtubule plus end polymerase; and ribonucleoprotein complex binding activity. Acts upstream of or within several processes, including central nervous system myelin formation; dendritic spine maintenance; and learning. Located in dendrite; neuronal ribonucleoprotein granule; and perikaryon. Is expressed in several structures, including nervous system; nose; respiratory system; thymus primordium; and tooth. Orthologous to human CKAP5 (cytoskeleton associated protein 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 33.2), CNS E14 (RPKM 22.3) and 21 other tissues See more
Orthologs
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Genomic context

See Ckap5 in Genome Data Viewer
Location:
2 E1; 2 50.63 cM
Exon count:
47
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (91357092..91451024)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (91526747..91620679)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene low density lipoprotein receptor-related protein 4 Neighboring gene STARR-positive B cell enhancer ABC_E5945 Neighboring gene predicted gene 13770 Neighboring gene small nucleolar RNA, C/D box 67 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:91475064-91475265 Neighboring gene coagulation factor II Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:91486007-91486292 Neighboring gene STARR-positive B cell enhancer ABC_E1007 Neighboring gene cytochrome c oxidase subunit 7B, mitochondrial pseudogene Neighboring gene zinc finger protein 408

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (4)  1 citation
  • Transgenic (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
 
enables microtubule plus end polymerase IBA
Inferred from Biological aspect of Ancestor
more info
 
enables microtubule plus-end binding IEA
Inferred from Electronic Annotation
more info
 
enables ribonucleoprotein complex binding ISO
Inferred from Sequence Orthology
more info
 
enables tubulin binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within central nervous system myelin formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within centrosome cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in centrosome duplication IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of cytoplasmic translation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cytoplasmic translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within dendritic spine maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment or maintenance of microtubule cytoskeleton polarity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in establishment or maintenance of microtubule cytoskeleton polarity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within excitatory postsynaptic potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within habituation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within long-term synaptic potentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mRNA localization resulting in post-transcriptional regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in microtubule polymerization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of microtubule nucleation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein-RNA complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein-RNA complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in spindle organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within visual learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with microtubule plus-end IBA
Inferred from Biological aspect of Ancestor
more info
 
colocalizes_with microtubule plus-end ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in perikaryon IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
PubMed 
is_active_in spindle pole IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in spindle pole ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cytoskeleton-associated protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001165989.2NP_001159461.1  cytoskeleton-associated protein 5 isoform 1

    See identical proteins and their annotated locations for NP_001159461.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL691489
    Consensus CDS
    CCDS50640.1
    UniProtKB/Swiss-Prot
    A0PJ77, A2AGT5, A2AGT6, B2RRC4, Q0VGR0, Q3TML9, Q3UDY6, Q4VAE7, Q9CUN0
    UniProtKB/TrEMBL
    K3W4R5
    Related
    ENSMUSP00000106970.4, ENSMUST00000111338.10
    Conserved Domains (1) summary
    pfam12348
    Location:8561048
    CLASP_N; CLASP N terminal
  2. NM_029437.2NP_083713.2  cytoskeleton-associated protein 5 isoform 2

    See identical proteins and their annotated locations for NP_083713.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    BC089032, BC096422
    Consensus CDS
    CCDS16433.1
    UniProtKB/Swiss-Prot
    A0PJ77, A2AGT5, A2AGT6, B2RRC4, Q0VGR0, Q3TML9, Q3UDY6, Q4VAE7, Q9CUN0
    UniProtKB/TrEMBL
    A0A0R4J0K2
    Related
    ENSMUSP00000046263.10, ENSMUST00000046769.16
    Conserved Domains (1) summary
    pfam12348
    Location:8561048
    CLASP_N; CLASP N terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    91357092..91451024
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500342.1XP_006500405.1  cytoskeleton-associated protein 5 isoform X1

    See identical proteins and their annotated locations for XP_006500405.1

    UniProtKB/Swiss-Prot
    A0PJ77, A2AGT5, A2AGT6, B2RRC4, Q0VGR0, Q3TML9, Q3UDY6, Q4VAE7, Q9CUN0
    Conserved Domains (1) summary
    pfam12348
    Location:8561048
    CLASP_N; CLASP N terminal
  2. XM_030252170.1XP_030108030.1  cytoskeleton-associated protein 5 isoform X1

    UniProtKB/Swiss-Prot
    A0PJ77, A2AGT5, A2AGT6, B2RRC4, Q0VGR0, Q3TML9, Q3UDY6, Q4VAE7, Q9CUN0
  3. XM_036162654.1XP_036018547.1  cytoskeleton-associated protein 5 isoform X2

    UniProtKB/Swiss-Prot
    A0PJ77, A2AGT5, A2AGT6, B2RRC4, Q0VGR0, Q3TML9, Q3UDY6, Q4VAE7, Q9CUN0
    UniProtKB/TrEMBL
    K3W4R5
  4. XM_006500343.4XP_006500406.1  cytoskeleton-associated protein 5 isoform X1

    See identical proteins and their annotated locations for XP_006500406.1

    UniProtKB/Swiss-Prot
    A0PJ77, A2AGT5, A2AGT6, B2RRC4, Q0VGR0, Q3TML9, Q3UDY6, Q4VAE7, Q9CUN0
    Conserved Domains (1) summary
    pfam12348
    Location:8561048
    CLASP_N; CLASP N terminal
  5. XM_036162653.1XP_036018546.1  cytoskeleton-associated protein 5 isoform X2

    UniProtKB/Swiss-Prot
    A0PJ77, A2AGT5, A2AGT6, B2RRC4, Q0VGR0, Q3TML9, Q3UDY6, Q4VAE7, Q9CUN0
    UniProtKB/TrEMBL
    K3W4R5
  6. XM_030252169.2XP_030108029.1  cytoskeleton-associated protein 5 isoform X1

    UniProtKB/Swiss-Prot
    A0PJ77, A2AGT5, A2AGT6, B2RRC4, Q0VGR0, Q3TML9, Q3UDY6, Q4VAE7, Q9CUN0