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ZNF28 zinc finger protein 28 [ Homo sapiens (human) ]

Gene ID: 7576, updated on 12-Oct-2019

Summary

Official Symbol
ZNF28provided by HGNC
Official Full Name
zinc finger protein 28provided by HGNC
Primary source
HGNC:HGNC:13073
See related
Ensembl:ENSG00000198538
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KOX24
Expression
Ubiquitous expression in thyroid (RPKM 2.8), colon (RPKM 1.6) and 25 other tissues See more
Orthologs

Genomic context

See ZNF28 in Genome Data Viewer
Location:
19q13.41
Exon count:
8
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (52797408..52821637, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (53300661..53324922, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372452 Neighboring gene uncharacterized LOC105372451 Neighboring gene zinc finger protein 600 Neighboring gene poly(A) binding protein nuclear 1 pseudogene Neighboring gene zinc finger protein 468 Neighboring gene zinc finger protein 320

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from BioSystems

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp781D0275

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific NAS
Non-traceable Author Statement
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger protein 28
Names
zinc finger protein KOX24

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001369761.1NP_001356690.1  zinc finger protein 28 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC008813
    Related
    ENSP00000469381.1, ENST00000594602.5
    Conserved Domains (1) summary
    pfam01352
    Location:748
    KRAB; KRAB box
  2. NM_001369762.1NP_001356691.1  zinc finger protein 28 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC008813
    Related
    ENSP00000375661.2, ENST00000391783.6
    Conserved Domains (3) summary
    COG5048
    Location:300661
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:211321
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:500520
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. NM_001369763.1NP_001356692.1  zinc finger protein 28 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC008813
    Conserved Domains (3) summary
    COG5048
    Location:350711
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:261371
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:550570
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. NM_001369764.1NP_001356693.1  zinc finger protein 28 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC008813
    Conserved Domains (4) summary
    COG5048
    Location:339700
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:250360
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:539559
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:748
    KRAB; KRAB box
  5. NM_001369765.1NP_001356694.1  zinc finger protein 28 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC008813
    Conserved Domains (3) summary
    COG5048
    Location:317678
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:228338
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:517537
    ZF_C2H2; C2H2 Zn finger [structural motif]
  6. NM_001369766.1NP_001356695.1  zinc finger protein 28 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC008813
    Conserved Domains (1) summary
    pfam01352
    Location:748
    KRAB; KRAB box
  7. NM_001369767.1NP_001356696.1  zinc finger protein 28 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC008813
  8. NM_001369768.1NP_001356697.1  zinc finger protein 28 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC008813, BC070146
    Conserved Domains (1) summary
    pfam01352
    Location:748
    KRAB; KRAB box
  9. NM_006969.5NP_008900.3  zinc finger protein 28 isoform 1

    See identical proteins and their annotated locations for NP_008900.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC008813
    Consensus CDS
    CCDS33093.2
    UniProtKB/Swiss-Prot
    P17035
    Related
    ENSP00000397693.2, ENST00000457749.7
    Conserved Domains (5) summary
    smart00349
    Location:848
    KRAB; krueppel associated box
    COG5048
    Location:267655
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:553573
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:397422
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_163139.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008813

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    52797408..52821637 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451686.1XP_024307454.1  zinc finger protein 28 isoform X3

    Conserved Domains (3) summary
    COG5048
    Location:241602
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:152262
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:441461
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. XM_024451688.1XP_024307456.1  zinc finger protein 28 isoform X4

    Conserved Domains (3) summary
    COG5048
    Location:300661
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:211321
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:500520
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. XM_011527262.2XP_011525564.1  zinc finger protein 28 isoform X1

    See identical proteins and their annotated locations for XP_011525564.1

    UniProtKB/Swiss-Prot
    P17035
    Conserved Domains (5) summary
    smart00349
    Location:848
    KRAB; krueppel associated box
    COG5048
    Location:267655
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:553573
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:397422
    zf-H2C2_2; Zinc-finger double domain
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