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Svip small VCP/p97-interacting protein [ Mus musculus (house mouse) ]

Gene ID: 75744, updated on 13-Oct-2022

Summary

Official Symbol
Svipprovided by MGI
Official Full Name
small VCP/p97-interacting proteinprovided by MGI
Primary source
MGI:MGI:1922994
See related
Ensembl:ENSMUSG00000074093 AllianceGenome:MGI:1922994
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700006C13Rik; 6620401M08Rik
Summary
Predicted to enable ATPase binding activity and protein self-association. Predicted to be involved in several processes, including negative regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly; negative regulation of retrograde protein transport, ER to cytosol; and regulation of cellular catabolic process. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and plasma membrane. Predicted to be active in endoplasmic reticulum membrane. Predicted to be anchored component of membrane. Orthologous to human SVIP (small VCP interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 18.1), cerebellum adult (RPKM 11.6) and 21 other tissues See more
Orthologs
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Genomic context

See Svip in Genome Data Viewer
Location:
7; 7 B4
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (51646909..51655766, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (51997161..52006018, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm683 Neighboring gene predicted gene, 33290 Neighboring gene Fanconi anemia, complementation group F Neighboring gene growth arrest specific 2 Neighboring gene RIKEN cDNA 1700015G11 gene Neighboring gene karyopherin alpha 7 (importin alpha 8) pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATPase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein self-association ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
small VCP/p97-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001160345.1NP_001153817.1  small VCP/p97-interacting protein

    See identical proteins and their annotated locations for NP_001153817.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein..
    Source sequence(s)
    AK158571, BX511488
    Consensus CDS
    CCDS57551.1
    UniProtKB/Swiss-Prot
    Q3UZP4
    UniProtKB/TrEMBL
    A0A6P5Q0D7, A0A8C6MUL0, Q3TYK1
    Related
    ENSMUSP00000096014.4, ENSMUST00000098414.5
    Conserved Domains (1) summary
    pfam15811
    Location:171
    SVIP; Small VCP/p97-interacting protein

RNA

  1. NR_027704.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' exon compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the 5' coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AC122017, AK005663, BX511488, BY089978

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    51646909..51655766 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)