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ZNF26 zinc finger protein 26 [ Homo sapiens (human) ]

Gene ID: 7574, updated on 12-Oct-2019

Summary

Official Symbol
ZNF26provided by HGNC
Official Full Name
zinc finger protein 26provided by HGNC
Primary source
HGNC:HGNC:13053
See related
Ensembl:ENSG00000198393 MIM:194537
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KOX20; HEL-179
Expression
Ubiquitous expression in bone marrow (RPKM 2.0), lymph node (RPKM 1.7) and 25 other tissues See more
Orthologs

Genomic context

See ZNF26 in Genome Data Viewer
Location:
12q24.33
Exon count:
9
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (132986365..133027102)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (133562934..133589154)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene zinc finger protein 605 Neighboring gene NANOGNB pseudogene 2 Neighboring gene RNA, U4atac small nuclear 12, pseudogene Neighboring gene ZNF84 divergent transcript Neighboring gene PTP4A1 pseudogene 2 Neighboring gene zinc finger protein 84

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
capsid gag The interaction of HIV-1 CA with human cellular zinc finger protein 26 (ZNF26) is identified by yeast two-hybrid screen PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20755

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific NAS
Non-traceable Author Statement
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger protein 26
Names
epididymis luminal protein 179
zinc finger protein KOX20

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256279.2NP_001243208.1  zinc finger protein 26 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC073911
    Conserved Domains (5) summary
    smart00349
    Location:47107
    KRAB; krueppel associated box
    COG5048
    Location:209557
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:489509
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4786
    KRAB; KRAB box
    pfam13465
    Location:501526
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001256280.2NP_001243209.1  zinc finger protein 26 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AC073911
    Conserved Domains (5) summary
    smart00349
    Location:1454
    KRAB; krueppel associated box
    COG5048
    Location:144492
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:424444
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:1453
    KRAB; KRAB box
    pfam13465
    Location:436461
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001330513.2NP_001317442.1  zinc finger protein 26 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in its 5' UTR and lacks an alternate exon in the 5' coding region compared to variant 1. This variant represents translation initiation at a downstream start codon compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream start codon to encode an isoform (4) that has a shorter N-terminus, compared to isoform 1. Variants 4 and 5 encode the same isoform (4).
    Source sequence(s)
    AC073911, BM718210, DA022426, DA107937, DA737586, DB239332, EU668356
    Consensus CDS
    CCDS81756.1
    UniProtKB/TrEMBL
    F5H6R4, V9HW07
  4. NM_001330514.2NP_001317443.1  zinc finger protein 26 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in its 5' UTR and lacks an alternate exon in the 5' coding region compared to variant 1. This variant represents translation initiation at a downstream start codon compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream start codon to encode an isoform (4) that has a shorter N-terminus, compared to isoform 1. Variants 4 and 5 encode the same isoform (4).
    Source sequence(s)
    AC073911, BM718210, DA107937, DA737586, DB232386, EU668356
    Consensus CDS
    CCDS81756.1
    UniProtKB/TrEMBL
    F5H6R4, V9HW07
  5. NM_019591.4NP_062537.2  zinc finger protein 26 isoform 2

    See identical proteins and their annotated locations for NP_062537.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC073911
    Consensus CDS
    CCDS31939.1
    UniProtKB/Swiss-Prot
    P17031
    UniProtKB/TrEMBL
    V9HW07
    Related
    ENSP00000333725.5, ENST00000328654.10
    Conserved Domains (3) summary
    smart00349
    Location:1474
    KRAB; krueppel associated box
    COG5048
    Location:200512
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:456476
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    132986365..133027102
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017019920.1XP_016875409.1  zinc finger protein 26 isoform X1

  2. XM_017019921.1XP_016875410.1  zinc finger protein 26 isoform X2

  3. XM_017019922.1XP_016875411.1  zinc finger protein 26 isoform X3

    UniProtKB/TrEMBL
    F5H6R4
    Related
    ENSP00000437420.1, ENST00000534834.1
    Conserved Domains (5) summary
    smart00349
    Location:154
    KRAB; krueppel associated box
    COG5048
    Location:156504
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:436456
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:133
    KRAB; KRAB box
    pfam13465
    Location:448473
    zf-H2C2_2; Zinc-finger double domain
  4. XM_005266183.3XP_005266240.1  zinc finger protein 26 isoform X3

    See identical proteins and their annotated locations for XP_005266240.1

    UniProtKB/TrEMBL
    F5H6R4
    Conserved Domains (5) summary
    smart00349
    Location:154
    KRAB; krueppel associated box
    COG5048
    Location:156504
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:436456
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:133
    KRAB; KRAB box
    pfam13465
    Location:448473
    zf-H2C2_2; Zinc-finger double domain
  5. XM_017019923.1XP_016875412.1  zinc finger protein 26 isoform X3

    UniProtKB/TrEMBL
    F5H6R4
    Conserved Domains (5) summary
    smart00349
    Location:154
    KRAB; krueppel associated box
    COG5048
    Location:156504
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:436456
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:133
    KRAB; KRAB box
    pfam13465
    Location:448473
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. XR_001748865.1 RNA Sequence

  2. XR_001748866.2 RNA Sequence

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