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Pank1 pantothenate kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 75735, updated on 26-Sep-2022

Summary

Official Symbol
Pank1provided by MGI
Official Full Name
pantothenate kinase 1provided by MGI
Primary source
MGI:MGI:1922985
See related
Ensembl:ENSMUSG00000033610 AllianceGenome:MGI:1922985
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pank; Pank1b
Summary
Enables pantothenate kinase activity. Acts upstream of or within coenzyme A biosynthetic process. Located in several cellular components, including cytosol; nucleus; and recycling endosome. Part of clathrin coat. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human PANK1 (pantothenate kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 4.1), liver adult (RPKM 3.2) and 28 other tissues See more
Orthologs
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Genomic context

See Pank1 in Genome Data Viewer
Location:
19 C1; 19
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (34784335..34862420, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (34806935..34883423, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 16 (monocarboxylic acid transporters), member 12 Neighboring gene predicted gene, 18425 Neighboring gene predicted gene, 22082 Neighboring gene microRNA 107 Neighboring gene kinesin family member 20B Neighboring gene microRNA 1950 Neighboring gene proteasome (prosome, macropain) subunit, alpha type 5 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

General gene information

Markers

Homology

Clone Names

  • 4632412I06Rik, 5430426F23Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables acetyl-CoA binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables pantothenate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables pantothenate kinase activity IDA
Inferred from Direct Assay
more info
 
enables pantothenate kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables pantothenate kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in coenzyme A biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within coenzyme A biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within coenzyme A biosynthetic process TAS
Traceable Author Statement
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell periphery IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
pantothenate kinase 1
Names
pantothenic acid kinase 1
NP_001107811.1
NP_076281.1
XP_006527490.1
XP_030106986.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114339.2NP_001107811.1  pantothenate kinase 1 isoform 1

    See identical proteins and their annotated locations for NP_001107811.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1, also known as alpha).
    Source sequence(s)
    AC113244, AC125259, AF200357, AK017345
    Consensus CDS
    CCDS50424.1
    UniProtKB/Swiss-Prot
    Q8K4K6, Q9QXM8
    Related
    ENSMUSP00000043562.6, ENSMUST00000036584.13
    Conserved Domains (1) summary
    pfam03630
    Location:189537
    Fumble; Fumble
  2. NM_023792.2NP_076281.1  pantothenate kinase 1 isoform 2

    See identical proteins and their annotated locations for NP_076281.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5'-terminal exon, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2, also known as beta) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC125259, AF200357
    Consensus CDS
    CCDS37966.1
    UniProtKB/Swiss-Prot
    Q8K4K6
    UniProtKB/TrEMBL
    A0A6P5NXE6, A0A8C6GIP7, Q543J7
    Related
    ENSMUSP00000108079.2, ENSMUST00000112460.3
    Conserved Domains (1) summary
    pfam03630
    Location:14362
    Fumble; Fumble

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    34784335..34862420 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527427.5XP_006527490.1  pantothenate kinase 1 isoform X1

    Conserved Domains (2) summary
    PHA03309
    Location:5185
    PHA03309; transcriptional regulator ICP4; Provisional
    pfam03630
    Location:189478
    Fumble
  2. XM_030251126.2XP_030106986.1  pantothenate kinase 1 isoform X2

    Conserved Domains (1) summary
    pfam03630
    Location:14303
    Fumble