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Amotl1 angiomotin-like 1 [ Mus musculus (house mouse) ]

Gene ID: 75723, updated on 12-Aug-2018

Summary

Official Symbol
Amotl1provided by MGI
Official Full Name
angiomotin-like 1provided by MGI
Primary source
MGI:MGI:1922973
See related
Ensembl:ENSMUSG00000013076 Vega:OTTMUSG00000034188
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
JEAP; mFLJ00155; 2310010G08Rik; 2310067L22Rik; 4932416D09Rik
Expression
Ubiquitous expression in subcutaneous fat pad adult (RPKM 21.7), mammary gland adult (RPKM 16.7) and 25 other tissues See more
Orthologs

Genomic context

See Amotl1 in Genome Data Viewer
Location:
9; 9 A2
Exon count:
19
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (14541966..14662960, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (14346410..14419444, complement)

Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene lysine (K)-specific demethylase 4D Neighboring gene CWC15 spliceosome-associated protein Neighboring gene predicted gene, 34263 Neighboring gene cyclin-dependent kinases regulatory subunit 2 pseudogene Neighboring gene predicted gene 7607

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Pathways from BioSystems

  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling by Hippo, organism-specific biosystem (from REACTOME)
    Signaling by Hippo, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Tight junction, organism-specific biosystem (from KEGG)
    Tight junction, organism-specific biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
  • Tight junction, conserved biosystem (from KEGG)
    Tight junction, conserved biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ00155

Gene Ontology Provided by MGI

Function Evidence Code Pubs
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
establishment of cell polarity involved in ameboidal cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
establishment of cell polarity involved in ameboidal cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
hippo signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hippo signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of blood vessel endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with COP9 signalosome ISO
Inferred from Sequence Orthology
more info
 
apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
bicellular tight junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
bicellular tight junction IDA
Inferred from Direct Assay
more info
PubMed 
bicellular tight junction ISO
Inferred from Sequence Orthology
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
angiomotin-like protein 1
Names
junction-enriched and -associated protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081395.1NP_001074864.1  angiomotin-like protein 1

    See identical proteins and their annotated locations for NP_001074864.1

    Status: PROVISIONAL

    Source sequence(s)
    CT030247, CT485607
    Consensus CDS
    CCDS40535.1
    UniProtKB/Swiss-Prot
    Q9D4H4
    Related
    ENSMUSP00000013220.6, OTTMUSP00000046960, ENSMUST00000013220.7, OTTMUST00000086703
    Conserved Domains (3) summary
    pfam12240
    Location:616818
    Angiomotin_C; Angiomotin C terminal
    cl02475
    Location:1651
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    cl12013
    Location:478650
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

    Range
    14541966..14662960 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510667.2XP_006510730.1  angiomotin-like protein 1 isoform X2

    Conserved Domains (2) summary
    pfam12240
    Location:652854
    Angiomotin_C; Angiomotin C terminal
    cl12013
    Location:514686
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  2. XM_006510666.2XP_006510729.1  angiomotin-like protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A1Y7VM69
    Related
    ENSMUSP00000152834.1, ENSMUST00000223132.1
    Conserved Domains (2) summary
    pfam12240
    Location:653855
    Angiomotin_C; Angiomotin C terminal
    cl12013
    Location:515687
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  3. XM_006510670.1XP_006510733.1  angiomotin-like protein 1 isoform X3

    See identical proteins and their annotated locations for XP_006510733.1

    UniProtKB/Swiss-Prot
    Q9D4H4
    Conserved Domains (2) summary
    pfam12240
    Location:530732
    Angiomotin_C; Angiomotin C terminal
    cl12013
    Location:392564
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  4. XM_006510668.1XP_006510731.1  angiomotin-like protein 1 isoform X3

    See identical proteins and their annotated locations for XP_006510731.1

    UniProtKB/Swiss-Prot
    Q9D4H4
    Conserved Domains (2) summary
    pfam12240
    Location:530732
    Angiomotin_C; Angiomotin C terminal
    cl12013
    Location:392564
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  5. XM_006510669.3XP_006510732.1  angiomotin-like protein 1 isoform X3

    See identical proteins and their annotated locations for XP_006510732.1

    UniProtKB/Swiss-Prot
    Q9D4H4
    Conserved Domains (2) summary
    pfam12240
    Location:530732
    Angiomotin_C; Angiomotin C terminal
    cl12013
    Location:392564
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
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