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Amotl1 angiomotin-like 1 [ Mus musculus (house mouse) ]

Gene ID: 75723, updated on 24-Apr-2022

Summary

Official Symbol
Amotl1provided by MGI
Official Full Name
angiomotin-like 1provided by MGI
Primary source
MGI:MGI:1922973
See related
Ensembl:ENSMUSG00000013076 AllianceGenome:MGI:1922973
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
JEAP; mFLJ00155; 2310010G08Rik; 2310067L22Rik; 4932416D09Rik
Summary
Predicted to enable identical protein binding activity. Acts upstream of or within establishment of cell polarity involved in ameboidal cell migration and positive regulation of blood vessel endothelial cell migration. Located in several cellular components, including apical plasma membrane; bicellular tight junction; and lamellipodium. Is expressed in brain and head. Orthologous to human AMOTL1 (angiomotin like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in subcutaneous fat pad adult (RPKM 21.7), mammary gland adult (RPKM 16.7) and 25 other tissues See more
Orthologs
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Genomic context

See Amotl1 in Genome Data Viewer
Location:
9; 9 A2
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (14453262..14574408, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (14541966..14662974, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (14346410..14419444, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene lysine (K)-specific demethylase 4D Neighboring gene CWC15 spliceosome-associated protein Neighboring gene predicted gene, 34263 Neighboring gene predicted gene 7607 Neighboring gene cyclin-dependent kinases regulatory subunit 2 pseudogene Neighboring gene NSA2 ribosome biogenesis homolog pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ00155

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of COP9 signalosome ISO
Inferred from Sequence Orthology
more info
 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in bicellular tight junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in bicellular tight junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in bicellular tight junction ISO
Inferred from Sequence Orthology
more info
 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
angiomotin-like protein 1
Names
junction-enriched and -associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081395.1NP_001074864.1  angiomotin-like protein 1

    See identical proteins and their annotated locations for NP_001074864.1

    Status: PROVISIONAL

    Source sequence(s)
    CT030247, CT485607
    Consensus CDS
    CCDS40535.1
    UniProtKB/Swiss-Prot
    Q9D4H4
    Related
    ENSMUSP00000013220.7, ENSMUST00000013220.8
    Conserved Domains (3) summary
    pfam12240
    Location:616818
    Angiomotin_C; Angiomotin C terminal
    cl02475
    Location:1651
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    cl12013
    Location:478650
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    14453262..14574408 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510666.4XP_006510729.1  angiomotin-like protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A1Y7VM69
    Related
    ENSMUSP00000152834.2, ENSMUST00000223132.2
    Conserved Domains (2) summary
    COG1196
    Location:486741
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12240
    Location:653855
    Angiomotin_C; Angiomotin C terminal
  2. XM_036155371.1XP_036011264.1  angiomotin-like protein 1 isoform X4

    Conserved Domains (2) summary
    TIGR02169
    Location:358619
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam12240
    Location:530736
    Angiomotin_C; Angiomotin C terminal
  3. XM_006510667.4XP_006510730.1  angiomotin-like protein 1 isoform X1

    Conserved Domains (2) summary
    COG1196
    Location:485740
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12240
    Location:652854
    Angiomotin_C; Angiomotin C terminal
  4. XM_030244693.2XP_030100553.1  angiomotin-like protein 1 isoform X4

    Conserved Domains (2) summary
    TIGR02169
    Location:358619
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam12240
    Location:530736
    Angiomotin_C; Angiomotin C terminal
  5. XM_006510670.3XP_006510733.1  angiomotin-like protein 1 isoform X4

    See identical proteins and their annotated locations for XP_006510733.1

    UniProtKB/Swiss-Prot
    Q9D4H4
    Conserved Domains (2) summary
    TIGR02169
    Location:358619
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam12240
    Location:530736
    Angiomotin_C; Angiomotin C terminal
  6. XM_006510668.2XP_006510731.1  angiomotin-like protein 1 isoform X4

    See identical proteins and their annotated locations for XP_006510731.1

    UniProtKB/Swiss-Prot
    Q9D4H4
    Conserved Domains (2) summary
    TIGR02169
    Location:358619
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam12240
    Location:530736
    Angiomotin_C; Angiomotin C terminal
  7. XM_030244692.2XP_030100552.1  angiomotin-like protein 1 isoform X3

    Conserved Domains (3) summary
    COG1196
    Location:448703
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl02475
    Location:1651
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    pfam12240
    Location:615817
    Angiomotin_C; Angiomotin C terminal
  8. XM_006510669.4XP_006510732.1  angiomotin-like protein 1 isoform X4

    See identical proteins and their annotated locations for XP_006510732.1

    UniProtKB/Swiss-Prot
    Q9D4H4
    Conserved Domains (2) summary
    TIGR02169
    Location:358619
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam12240
    Location:530736
    Angiomotin_C; Angiomotin C terminal