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Cul5 cullin 5 [ Mus musculus (house mouse) ]

Gene ID: 75717, updated on 26-Jun-2024

Summary

Official Symbol
Cul5provided by MGI
Official Full Name
cullin 5provided by MGI
Primary source
MGI:MGI:1922967
See related
Ensembl:ENSMUSG00000032030 AllianceGenome:MGI:1922967
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
VACM1; VACM-1; 4921514I20Rik; 8430423K24Rik; C030032G03Rik; C330021I08Rik
Summary
Predicted to enable ubiquitin protein ligase binding activity and ubiquitin-protein transferase activity. Acts upstream of or within cerebral cortex radially oriented cell migration; protein ubiquitination; and radial glia guided migration of Purkinje cell. Predicted to be located in several cellular components, including nucleus; plasma membrane; and site of DNA damage. Predicted to be part of Cul5-RING ubiquitin ligase complex and SCF ubiquitin ligase complex. Is expressed in several structures, including brain; eye; genitourinary system; gut; and limb bud. Orthologous to human CUL5 (cullin 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 7.1), CNS E18 (RPKM 5.9) and 28 other tissues See more
Orthologs
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Genomic context

See Cul5 in Genome Data Viewer
Location:
9 A5.3; 9 29.12 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (53525881..53578807, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (53614581..53667507, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene nuclear protein in the AT region Neighboring gene STARR-seq mESC enhancer starr_24146 Neighboring gene acetyl-Coenzyme A acetyltransferase 1 Neighboring gene STARR-positive B cell enhancer ABC_E1384 Neighboring gene predicted gene, 22304 Neighboring gene STARR-positive B cell enhancer ABC_E10546 Neighboring gene STARR-seq mESC enhancer starr_24147 Neighboring gene predicted gene 16124 Neighboring gene ribosomal protein S6, pseudogene 3 Neighboring gene STARR-positive B cell enhancer ABC_E1114 Neighboring gene RAB39, member RAS oncogene family Neighboring gene STARR-seq mESC enhancer starr_24150 Neighboring gene solute carrier family 35, member F2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (2) 
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-macromolecule adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of Cul5-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of Cul5-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of cullin-RING ubiquitin ligase complex IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in site of DNA damage ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cullin-5
Names
CUL-5
vasopressin-activated calcium-mobilizing receptor protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161618.2NP_001155090.2  cullin-5 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC158384
    Consensus CDS
    CCDS52798.1
    UniProtKB/TrEMBL
    E9PV12, G3X914
    Related
    ENSMUSP00000133144.3, ENSMUST00000166367.8
    Conserved Domains (2) summary
    pfam00888
    Location:19645
    Cullin; Cullin family
    pfam10557
    Location:686745
    Cullin_Nedd8; Cullin protein neddylation domain
  2. NM_027807.4NP_082083.3  cullin-5 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC158384
    Consensus CDS
    CCDS40638.2
    UniProtKB/Swiss-Prot
    Q8BMQ6, Q8BV53, Q8C098, Q9D5V5
    UniProtKB/TrEMBL
    G3X914, Q2M4H5
    Related
    ENSMUSP00000034529.8, ENSMUST00000034529.14
    Conserved Domains (2) summary
    pfam00888
    Location:19672
    Cullin; Cullin family
    pfam10557
    Location:713772
    Cullin_Nedd8; Cullin protein neddylation domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    53525881..53578807 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017313680.3XP_017169169.1  cullin-5 isoform X1

    UniProtKB/TrEMBL
    E9Q6Z0
    Related
    ENSMUSP00000113490.2, ENSMUST00000120122.8
    Conserved Domains (2) summary
    pfam00888
    Location:6543
    Cullin; Cullin family
    pfam10557
    Location:584641
    Cullin_Nedd8; Cullin protein neddylation domain