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Shld2 shieldin complex subunit 2 [ Mus musculus (house mouse) ]

Gene ID: 75698, updated on 8-Dec-2022

Summary

Official Symbol
Shld2provided by MGI
Official Full Name
shieldin complex subunit 2provided by MGI
Primary source
MGI:MGI:1922948
See related
Ensembl:ENSMUSG00000041471 AllianceGenome:MGI:1922948
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fam35a; 3110001K24Rik
Summary
Predicted to be involved in negative regulation of double-strand break repair via homologous recombination; positive regulation of double-strand break repair via nonhomologous end joining; and positive regulation of isotype switching. Predicted to act upstream of or within DNA repair. Predicted to be located in chromosome. Predicted to be active in nucleus and site of double-strand break. Orthologous to human SHLD2 (shieldin complex subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E18 (RPKM 3.2), liver adult (RPKM 2.5) and 26 other tissues See more
Orthologs
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Genomic context

See Shld2 in Genome Data Viewer
Location:
14; 14 B
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (33958905..34032528, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (34236948..34310651, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm340 Neighboring gene G protein regulated inducer of neurite outgrowth 2 Neighboring gene synaptotagmin XV Neighboring gene zinc finger, DHHC domain containing 17 pseudogene Neighboring gene glutamate dehydrogenase 1 Neighboring gene B-cell CLL/lymphoma 7C pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Component Evidence Code Pubs
located_in chromatin NAS
Non-traceable Author Statement
more info
PubMed 
located_in chromosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in site of double-strand break IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in site of double-strand break ISO
Inferred from Sequence Orthology
more info
 
located_in site of double-strand break NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
shieldin complex subunit 2
Names
RINN1-REV7-interacting novel NHEJ regulator 2
family with sequence similarity 35, member A
protein FAM35A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360074.1NP_001347003.1  shieldin complex subunit 2

    Status: VALIDATED

    Source sequence(s)
    AC154738, AK149442, BE630700, BE648821, BE848901, BF467362, BQ829235, BU756157
    Consensus CDS
    CCDS36874.1
    UniProtKB/Swiss-Prot
    E9Q8K3
    Conserved Domains (1) summary
    pfam15793
    Location:695866
    FAM35_C; Protein family FAM35, C-terminal
  2. NM_029389.3NP_083665.2  shieldin complex subunit 2

    See identical proteins and their annotated locations for NP_083665.2

    Status: VALIDATED

    Source sequence(s)
    AI451789, AK149442, BF467362, BU756157, CD547520
    Consensus CDS
    CCDS36874.1
    UniProtKB/Swiss-Prot
    E9Q8K3, Q3UEN2
    Related
    ENSMUSP00000107548.2, ENSMUST00000111917.3
    Conserved Domains (1) summary
    pfam15793
    Location:695866
    FAM35_C; Protein family FAM35, C-terminal

RNA

  1. NR_153399.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154738, AC160930, AK149442, BE630700, BE848901, BF467362, BQ829235, BU756157

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    33958905..34032528 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006519652.5XP_006519715.1  shieldin complex subunit 2 isoform X4

    See identical proteins and their annotated locations for XP_006519715.1

    Conserved Domains (1) summary
    pfam15793
    Location:143314
    FAM35_C; Protein family FAM35, C-terminal
  2. XM_017316219.3XP_017171708.1  shieldin complex subunit 2 isoform X4

    Conserved Domains (1) summary
    pfam15793
    Location:143314
    FAM35_C; Protein family FAM35, C-terminal
  3. XM_011245218.4XP_011243520.1  shieldin complex subunit 2 isoform X2

    Conserved Domains (1) summary
    pfam15793
    Location:659830
    FAM35_C; Protein family FAM35, C-terminal
  4. XM_006519650.5XP_006519713.1  shieldin complex subunit 2 isoform X3

    Conserved Domains (1) summary
    pfam15793
    Location:178349
    FAM35_C; Protein family FAM35, C-terminal
  5. XM_006519651.4XP_006519714.1  shieldin complex subunit 2 isoform X4

    See identical proteins and their annotated locations for XP_006519714.1

    Conserved Domains (1) summary
    pfam15793
    Location:143314
    FAM35_C; Protein family FAM35, C-terminal
  6. XM_011245216.4XP_011243518.1  shieldin complex subunit 2 isoform X1

    See identical proteins and their annotated locations for XP_011243518.1

    UniProtKB/Swiss-Prot
    E9Q8K3, Q3UEN2
    Conserved Domains (1) summary
    pfam15793
    Location:695866
    FAM35_C; Protein family FAM35, C-terminal
  7. XM_006519646.5XP_006519709.1  shieldin complex subunit 2 isoform X1

    See identical proteins and their annotated locations for XP_006519709.1

    UniProtKB/Swiss-Prot
    E9Q8K3, Q3UEN2
    Conserved Domains (1) summary
    pfam15793
    Location:695866
    FAM35_C; Protein family FAM35, C-terminal
  8. XM_006519648.5XP_006519711.1  shieldin complex subunit 2 isoform X1

    See identical proteins and their annotated locations for XP_006519711.1

    UniProtKB/Swiss-Prot
    E9Q8K3, Q3UEN2
    Conserved Domains (1) summary
    pfam15793
    Location:695866
    FAM35_C; Protein family FAM35, C-terminal
  9. XM_006519645.5XP_006519708.1  shieldin complex subunit 2 isoform X1

    See identical proteins and their annotated locations for XP_006519708.1

    UniProtKB/Swiss-Prot
    E9Q8K3, Q3UEN2
    Conserved Domains (1) summary
    pfam15793
    Location:695866
    FAM35_C; Protein family FAM35, C-terminal

RNA

  1. XR_001781163.3 RNA Sequence