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ZNF182 zinc finger protein 182 [ Homo sapiens (human) ]

Gene ID: 7569, updated on 23-Nov-2021

Summary

Official Symbol
ZNF182provided by HGNC
Official Full Name
zinc finger protein 182provided by HGNC
Primary source
HGNC:HGNC:13001
See related
Ensembl:ENSG00000147118 MIM:314993
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KOX14; ZNF21; HHZ150; Zfp182
Summary
Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This gene encodes a zinc finger protein, and belongs to the krueppel C2H2-type zinc-finger protein family. It may be involved in transcriptional regulation. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, May 2010]
Expression
Ubiquitous expression in thyroid (RPKM 3.7), lymph node (RPKM 3.6) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF182 in Genome Data Viewer
Location:
Xp11.23
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (47974851..48003989, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (47834250..47863388, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7 pseudogene 57 Neighboring gene zinc finger protein 81 Neighboring gene CRISPRi-FlowFISH-validated HDAC6 regulatory element Neighboring gene sperm acrosome associated 5 Neighboring gene ZNF630 antisense RNA 1 Neighboring gene zinc finger protein 630

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of zinc finger protein 182 (ZNF182) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ98691, MGC125383, MGC131713

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 182
Names
zinc finger protein 21 (KOX 14)
zinc finger protein KOX14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021254.1 RefSeqGene

    Range
    5007..34145
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001007088.2NP_001007089.1  zinc finger protein 182 isoform 2

    See identical proteins and their annotated locations for NP_001007089.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an internal exon in the 5' region, resulting in an upstream AUG start codon, as compared to variant 1. The encoded isoform 2 is shorter and has an alternate N-terminus, as compared to isoform 1.
    Source sequence(s)
    AC244636, AK122874, AW291763, BX648401, CN311292
    Consensus CDS
    CCDS35235.1
    UniProtKB/Swiss-Prot
    P17025
    Related
    ENSP00000366142.4, ENST00000376943.8
    Conserved Domains (3) summary
    smart00349
    Location:866
    KRAB; krueppel associated box
    COG5048
    Location:213601
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:525545
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_001178099.2NP_001171570.1  zinc finger protein 182 isoform 1

    See identical proteins and their annotated locations for NP_001171570.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an additional segment in the 5' UTR, as compared to variant 1. This variant and variant 1 encode the same isoform (1).
    Source sequence(s)
    AK122874, BC114216, DC377274
    Consensus CDS
    CCDS35236.1
    UniProtKB/Swiss-Prot
    P17025
    Related
    ENSP00000380165.1, ENST00000396965.5
    Conserved Domains (6) summary
    smart00349
    Location:2785
    KRAB; krueppel associated box
    COG5048
    Location:147553
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:544564
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:374396
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:2766
    KRAB; KRAB box
    pfam13465
    Location:587609
    zf-H2C2_2; Zinc-finger double domain
  3. NM_006962.2NP_008893.1  zinc finger protein 182 isoform 1

    See identical proteins and their annotated locations for NP_008893.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC244636, AK122874, AW291763, BX648401, CD642892
    Consensus CDS
    CCDS35236.1
    UniProtKB/Swiss-Prot
    P17025
    Conserved Domains (6) summary
    smart00349
    Location:2785
    KRAB; krueppel associated box
    COG5048
    Location:147553
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:544564
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:374396
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:2766
    KRAB; KRAB box
    pfam13465
    Location:587609
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    47974851..48003989 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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