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ZNF708 zinc finger protein 708 [ Homo sapiens (human) ]

Gene ID: 7562, updated on 23-Nov-2021

Summary

Official Symbol
ZNF708provided by HGNC
Official Full Name
zinc finger protein 708provided by HGNC
Primary source
HGNC:HGNC:12945
See related
Ensembl:ENSG00000182141
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KOX8; ZNF15; ZNF15L1
Expression
Ubiquitous expression in brain (RPKM 4.2), ovary (RPKM 3.4) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF708 in Genome Data Viewer
Location:
19p12
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (21290385..21329437, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (21473962..21512212, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase assembly protein COX16 homolog, mitochondrial pseudogene Neighboring gene vomeronasal 1 receptor 83 pseudogene Neighboring gene BCL2 interacting protein 3 pseudogene 25 Neighboring gene zinc finger protein 738 Neighboring gene iron-sulfur cluster assembly 1 homolog (S. cerevisiae) pseudogene Neighboring gene zinc finger protein 493

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ16755, FLJ46310, DKFZp686L10267

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger protein 708
Names
ZNF15, ZNF15L1
zinc finger protein 15-like 1 (KOX 8)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001297560.2NP_001284489.1  zinc finger protein 708 isoform 2

    See identical proteins and their annotated locations for NP_001284489.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. Variants 2 and 3 encode the same isoform (2), which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC022432, AK311130, BX103920, BX647526, CD704852, DB216212
    UniProtKB/Swiss-Prot
    P17019
    Conserved Domains (3) summary
    COG5048
    Location:78488
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:190210
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:258282
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001297561.2NP_001284490.1  zinc finger protein 708 isoform 2

    See identical proteins and their annotated locations for NP_001284490.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. Variants 2 and 3 encode the same isoform (2), which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC022432, AK311130, BX103920, BX647526, CD704852
    UniProtKB/Swiss-Prot
    P17019
    Conserved Domains (3) summary
    COG5048
    Location:78488
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:190210
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:258282
    zf-H2C2_2; Zinc-finger double domain
  3. NM_021269.3NP_067092.2  zinc finger protein 708 isoform 1

    See identical proteins and their annotated locations for NP_067092.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC022432
    Consensus CDS
    CCDS32980.1
    Related
    ENSP00000349401.2, ENST00000356929.3
    Conserved Domains (5) summary
    smart00349
    Location:464
    KRAB; krueppel associated box
    COG5048
    Location:142552
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:254274
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:443
    KRAB; KRAB box
    pfam13465
    Location:322346
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    21290385..21329437 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027203.2XP_016882692.1  zinc finger protein 708 isoform X2

  2. XM_017027202.2XP_016882691.1  zinc finger protein 708 isoform X2

  3. XM_017027204.2XP_016882693.1  zinc finger protein 708 isoform X3

  4. XM_017027201.1XP_016882690.1  zinc finger protein 708 isoform X1

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