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Gns glucosamine (N-acetyl)-6-sulfatase [ Mus musculus (house mouse) ]

Gene ID: 75612, updated on 12-May-2024

Summary

Official Symbol
Gnsprovided by MGI
Official Full Name
glucosamine (N-acetyl)-6-sulfataseprovided by MGI
Primary source
MGI:MGI:1922862
See related
Ensembl:ENSMUSG00000034707 AllianceGenome:MGI:1922862
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
G6S; 2610016K11Rik
Summary
Predicted to enable N-acetylglucosamine-6-sulfatase activity; glycosaminoglycan binding activity; and sulfate binding activity. Predicted to be involved in keratan sulfate catabolic process. Located in lysosome. Is expressed in several structures, including eye; nervous system; skeleton; and spleen primordium. Used to study mucopolysaccharidosis III. Human ortholog(s) of this gene implicated in mucopolysaccharidosis III and mucopolysaccharidosis type IIID. Orthologous to human GNS (glucosamine (N-acetyl)-6-sulfatase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 66.2), kidney adult (RPKM 51.5) and 28 other tissues See more
Orthologs
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Genomic context

See Gns in Genome Data Viewer
Location:
10 D2; 10 69.62 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (121200995..121233159)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (121365090..121397254)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene TBC1 domain family, member 30 Neighboring gene STARR-seq mESC enhancer starr_28084 Neighboring gene ribosomal protein L21 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9808 Neighboring gene STARR-positive B cell enhancer ABC_E11462 Neighboring gene predicted gene, 40785 Neighboring gene STARR-positive B cell enhancer ABC_E9809 Neighboring gene mitochondrial ribosomal protein S11 pseudogene Neighboring gene Ras association (RalGDS/AF-6) domain family member 3 Neighboring gene STARR-positive B cell enhancer ABC_E5194 Neighboring gene predicted gene, 53638

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-acetylglucosamine-6-sulfatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables N-acetylglucosamine-6-sulfatase activity ISO
Inferred from Sequence Orthology
more info
 
enables glycosaminoglycan binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables glycosaminoglycan binding ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables sulfate binding ISO
Inferred from Sequence Orthology
more info
 
enables sulfuric ester hydrolase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
involved_in glycosaminoglycan metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in keratan sulfate catabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in lysosome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
N-acetylglucosamine-6-sulfatase
NP_001351624.1
NP_083640.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364695.1NP_001351624.1  N-acetylglucosamine-6-sulfatase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC140264
    Conserved Domains (1) summary
    cd16147
    Location:1269
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
  2. NM_029364.4NP_083640.1  N-acetylglucosamine-6-sulfatase isoform 1 precursor

    See identical proteins and their annotated locations for NP_083640.1

    Status: VALIDATED

    Source sequence(s)
    AC140264
    Consensus CDS
    CCDS24210.1
    UniProtKB/Swiss-Prot
    Q3TWT0, Q8BFR4, Q8BJJ7, Q8BK91
    UniProtKB/TrEMBL
    Q3UBB0
    Related
    ENSMUSP00000043167.7, ENSMUST00000040344.7
    Conserved Domains (2) summary
    COG3119
    Location:35496
    AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
    cd16147
    Location:38487
    G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    121200995..121233159
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)