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Wnk2 WNK lysine deficient protein kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 75607, updated on 12-Aug-2019

Summary

Official Symbol
Wnk2provided by MGI
Official Full Name
WNK lysine deficient protein kinase 2provided by MGI
Primary source
MGI:MGI:1922857
See related
Ensembl:ENSMUSG00000037989
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ESTM15; X83337; AW122246; mKIAA1760; 1810073P09Rik
Expression
Broad expression in whole brain E14.5 (RPKM 9.8), cerebellum adult (RPKM 9.2) and 20 other tissues See more
Orthologs

Genomic context

See Wnk2 in Genome Data Viewer
Location:
13 A5; 13 25.07 cM
Exon count:
33
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (49036302..49148574, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (49131671..49243383, complement)

Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 120A, opposite strand Neighboring gene kinesin family member 11 pseudogene Neighboring gene predicted gene, 40942 Neighboring gene predicted gene, 40943

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
chloride channel inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
potassium channel inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of sodium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of potassium ion import IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of sodium ion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of sodium ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase WNK2
Names
protein kinase lysine-deficient 2
protein kinase with no lysine 2
NP_001277240.1
NP_001277242.1
NP_083637.2
XP_006517037.1
XP_006517040.1
XP_006517042.1
XP_011242717.1
XP_011242718.1
XP_011242719.1
XP_011242720.1
XP_011242721.1
XP_011242722.1
XP_011242723.1
XP_011242724.1
XP_011242725.1
XP_011242726.1
XP_011242727.1
XP_011242728.1
XP_011242729.1
XP_017171115.1
XP_017171116.1
XP_030103304.1
XP_030103305.1
XP_030103306.1
XP_030103307.1
XP_030103308.1
XP_030103309.1
XP_030103310.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290311.1NP_001277240.1  serine/threonine-protein kinase WNK2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). This variant is partially supported by the mRNA AK044381.1; the 5' exon structure is inferred based on other transcript alignments at this gene.
    Source sequence(s)
    AA145730, AC160126, AK044381, AK147550, BM941970
    Consensus CDS
    CCDS70454.1
    UniProtKB/Swiss-Prot
    Q3UH66
    UniProtKB/TrEMBL
    E9QM73
    Related
    ENSMUSP00000089212.3, ENSMUST00000091623.9
    Conserved Domains (3) summary
    smart00220
    Location:200453
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14032
    Location:193458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474511
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  2. NM_001290313.1NP_001277242.1  serine/threonine-protein kinase WNK2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains alternate 3' exon structure, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a. This variant is partially supported by the mRNA BC060187.1; the 5' exon structure is inferred based on other transcript alignments at this gene.
    Source sequence(s)
    AC160126, AI464179, AK147550, BC060187, BM941970
    Consensus CDS
    CCDS70455.1
    UniProtKB/Swiss-Prot
    Q3UH66
    UniProtKB/TrEMBL
    E9QMI8
    Related
    ENSMUSP00000105724.2, ENSMUST00000110097.8
    Conserved Domains (3) summary
    smart00220
    Location:200453
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14032
    Location:193458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474511
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  3. NM_029361.4NP_083637.2  serine/threonine-protein kinase WNK2 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons and contains alternate 3' exon structure, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (c) has a distinct C-terminus and is shorter than isoform a. This variant is mostly supported by the mRNA AK147550.1, but with correction of a non-consensus splice site.
    Source sequence(s)
    AC160126, AI464179, AK147550, BM941970
    UniProtKB/Swiss-Prot
    Q3UH66
    Related
    ENSMUSP00000047231.6, ENSMUST00000035538.12
    Conserved Domains (3) summary
    smart00220
    Location:200453
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14032
    Location:193458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474511
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000079.6 Reference GRCm38.p6 C57BL/6J

    Range
    49036302..49148574 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516979.3XP_006517042.1  serine/threonine-protein kinase WNK2 isoform X24

    Related
    ENSMUSP00000125539.1, ENSMUST00000162403.7
    Conserved Domains (3) summary
    smart00220
    Location:200453
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14032
    Location:193458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474511
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  2. XM_030247449.1XP_030103309.1  serine/threonine-protein kinase WNK2 isoform X20

  3. XM_030247446.1XP_030103306.1  serine/threonine-protein kinase WNK2 isoform X13

  4. XM_011244426.2XP_011242728.1  serine/threonine-protein kinase WNK2 isoform X22

    Conserved Domains (3) summary
    smart00220
    Location:200453
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14032
    Location:193458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474511
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  5. XM_017315627.2XP_017171116.1  serine/threonine-protein kinase WNK2 isoform X19

  6. XM_030247448.1XP_030103308.1  serine/threonine-protein kinase WNK2 isoform X17

  7. XM_011244425.2XP_011242727.1  serine/threonine-protein kinase WNK2 isoform X15

    Related
    ENSMUSP00000049327.8, ENSMUST00000049265.14
    Conserved Domains (3) summary
    smart00220
    Location:200453
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14032
    Location:193458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474511
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  8. XM_017315626.2XP_017171115.1  serine/threonine-protein kinase WNK2 isoform X12

  9. XM_030247445.1XP_030103305.1  serine/threonine-protein kinase WNK2 isoform X10

  10. XM_011244422.2XP_011242724.1  serine/threonine-protein kinase WNK2 isoform X9

    Conserved Domains (3) summary
    smart00220
    Location:200453
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14032
    Location:193458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474511
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  11. XM_030247447.1XP_030103307.1  serine/threonine-protein kinase WNK2 isoform X16

  12. XM_011244415.3XP_011242717.1  serine/threonine-protein kinase WNK2 isoform X1

    Conserved Domains (3) summary
    smart00220
    Location:200453
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14032
    Location:193458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474511
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  13. XM_006516977.3XP_006517040.1  serine/threonine-protein kinase WNK2 isoform X21

    UniProtKB/TrEMBL
    E9QMI9
    Related
    ENSMUSP00000105723.1, ENSMUST00000110096.7
    Conserved Domains (3) summary
    smart00220
    Location:200453
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14032
    Location:193458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474511
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  14. XM_006516974.4XP_006517037.1  serine/threonine-protein kinase WNK2 isoform X18

    Conserved Domains (3) summary
    smart00220
    Location:200453
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14032
    Location:193458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474511
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  15. XM_011244416.3XP_011242718.1  serine/threonine-protein kinase WNK2 isoform X2

    Conserved Domains (3) summary
    smart00220
    Location:200453
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14032
    Location:193458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474511
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  16. XM_011244424.3XP_011242726.1  serine/threonine-protein kinase WNK2 isoform X14

    Conserved Domains (3) summary
    smart00220
    Location:200453
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14032
    Location:193458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474511
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  17. XM_011244423.3XP_011242725.1  serine/threonine-protein kinase WNK2 isoform X11

    Conserved Domains (3) summary
    smart00220
    Location:200453
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14032
    Location:193458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474511
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  18. XM_011244421.3XP_011242723.1  serine/threonine-protein kinase WNK2 isoform X8

    Conserved Domains (3) summary
    smart00220
    Location:200453
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14032
    Location:193458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474511
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  19. XM_011244420.3XP_011242722.1  serine/threonine-protein kinase WNK2 isoform X6

    Conserved Domains (3) summary
    smart00220
    Location:200453
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14032
    Location:193458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474511
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  20. XM_030247444.1XP_030103304.1  serine/threonine-protein kinase WNK2 isoform X7

  21. XM_011244419.3XP_011242721.1  serine/threonine-protein kinase WNK2 isoform X5

    Conserved Domains (3) summary
    smart00220
    Location:200453
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14032
    Location:193458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474511
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  22. XM_011244417.3XP_011242719.1  serine/threonine-protein kinase WNK2 isoform X3

    Conserved Domains (3) summary
    smart00220
    Location:200453
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14032
    Location:193458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474511
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  23. XM_011244418.2XP_011242720.1  serine/threonine-protein kinase WNK2 isoform X4

    Conserved Domains (3) summary
    smart00220
    Location:200453
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14032
    Location:193458
    STKc_WNK2_like; Catalytic domain of With No Lysine (WNK) 2-like Serine/Threonine kinases
    pfam12202
    Location:474511
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  24. XM_011244427.3XP_011242729.1  serine/threonine-protein kinase WNK2 isoform X23

    Conserved Domains (3) summary
    smart00220
    Location:1209
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam12202
    Location:230267
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
    cl21453
    Location:1214
    PKc_like; Protein Kinases, catalytic domain
  25. XM_030247450.1XP_030103310.1  serine/threonine-protein kinase WNK2 isoform X25

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