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ZNF12 zinc finger protein 12 [ Homo sapiens (human) ]

Gene ID: 7559, updated on 5-Jan-2022

Summary

Official Symbol
ZNF12provided by HGNC
Official Full Name
zinc finger protein 12provided by HGNC
Primary source
HGNC:HGNC:12902
See related
Ensembl:ENSG00000164631 MIM:194536
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KOX3; HZF11; GIOT-3; ZNF325
Summary
This gene is a member of the krueppel C2H2-type zinc-finger protein family and encodes a protein with eight C2H2-type zinc fingers and a KRAB domain. This nuclear protein is involved in developmental control of gene expression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 9.8), endometrium (RPKM 8.4) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF12 in Genome Data Viewer
Location:
7p22.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (6688433..6706947, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (6728064..6746578, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 15225 Neighboring gene zinc finger protein 316 Neighboring gene zinc finger protein 33B pseudogene Neighboring gene speedy/RINGO cell cycle regulator family member E20, pseudogene Neighboring gene PMS2 C-terminal like pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of zinc finger protein 12 (ZNF12) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in centrosome IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 12
Names
gonadotropin inducible transcription repressor 3
gonadotropin-inducible ovary transcription repressor 3
zinc finger protein 11
zinc finger protein 325
zinc finger protein KOX3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006956.3NP_008887.2  zinc finger protein 12 isoform b

    See identical proteins and their annotated locations for NP_008887.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment, compared to variant 1, resulting in a shorter protein (isoform b), compared to isoform a.
    Source sequence(s)
    AC073343, AI879099, BC051892, BX114779
    Consensus CDS
    CCDS47539.1
    UniProtKB/Swiss-Prot
    P17014
    Related
    ENSP00000344745.5, ENST00000342651.9
    Conserved Domains (6) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:269645
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:289309
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:539561
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:441466
    zf-H2C2_2; Zinc-finger double domain
  2. NM_016265.4NP_057349.2  zinc finger protein 12 isoform a

    See identical proteins and their annotated locations for NP_057349.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC073343, AF505656, AI879099, BC051892, BX114779
    Consensus CDS
    CCDS47538.1
    UniProtKB/Swiss-Prot
    P17014
    Related
    ENSP00000385939.1, ENST00000405858.6
    Conserved Domains (6) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:307683
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:327347
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:577599
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:479504
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    6688433..6706947 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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