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ZNF10 zinc finger protein 10 [ Homo sapiens (human) ]

Gene ID: 7556, updated on 23-Nov-2021

Summary

Official Symbol
ZNF10provided by HGNC
Official Full Name
zinc finger protein 10provided by HGNC
Primary source
HGNC:HGNC:12879
See related
Ensembl:ENSG00000256223 MIM:194538
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KOX1
Summary
The protein encoded by this gene contains a C2H2 zinc finger, and has been shown to function as a transcriptional repressor. The Kruppel-associated box (KRAB) domain of this protein is found to be responsible for its transcriptional repression activity. RING finger containing protein TIF1 was reported to interact with the KRAB domain, and may serve as a mediator for the repression activity of this protein. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 6.7), thyroid (RPKM 5.7) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF10 in Genome Data Viewer
Location:
12q24.33
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (133130627..133159465)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (133707213..133736051)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene zinc finger protein 140 Neighboring gene zinc finger protein 891 Neighboring gene ribosomal protein L23a pseudogene 67 Neighboring gene zinc finger protein 268 Neighboring gene anomalous homeobox

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: ZNF268

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 10
Names
zinc finger protein 10 (KOX 1)
zinc finger protein KOX1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015394.5NP_056209.2  zinc finger protein 10

    See identical proteins and their annotated locations for NP_056209.2

    Status: REVIEWED

    Source sequence(s)
    AC026786, AI972895, AL110188, BC024182, BE895826
    Consensus CDS
    CCDS9283.1
    UniProtKB/Swiss-Prot
    P21506
    UniProtKB/TrEMBL
    Q9UG14
    Related
    ENSP00000248211.6, ENST00000248211.11
    Conserved Domains (3) summary
    smart00349
    Location:1473
    KRAB; krueppel associated box
    COG5048
    Location:272474
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:435455
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    133130627..133159465
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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