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ZNF10 zinc finger protein 10 [ Homo sapiens (human) ]

Gene ID: 7556, updated on 5-Jul-2025
Official Symbol
ZNF10provided by HGNC
Official Full Name
zinc finger protein 10provided by HGNC
Primary source
HGNC:HGNC:12879
See related
Ensembl:ENSG00000256223 MIM:194538; AllianceGenome:HGNC:12879
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KOX1
Summary
The protein encoded by this gene contains a C2H2 zinc finger, and has been shown to function as a transcriptional repressor. The Kruppel-associated box (KRAB) domain of this protein is found to be responsible for its transcriptional repression activity. RING finger containing protein TIF1 was reported to interact with the KRAB domain, and may serve as a mediator for the repression activity of this protein. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 6.7), thyroid (RPKM 5.7) and 25 other tissues See more
Orthologs
all
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See ZNF10 in Genome Data Viewer
Location:
12q24.33
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (133130627..133159465)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (133187943..133216780)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (133707213..133736051)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7398 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7399 Neighboring gene zinc finger protein 140 Neighboring gene zinc finger protein 891 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_26217 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5135 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5136 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7400 Neighboring gene ribosomal protein L23a pseudogene 67 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_26228 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:133731795-133732994 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_26242 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:133757799-133758323 Neighboring gene zinc finger protein 268 Neighboring gene anomalous homeobox

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. ZNF10 inhibits HIV-1 LTR activity through interaction with NF-κB and Sp1 binding motifs. Nishitsuji H, et al. FEBS Lett, 2015 Jul 8. PMID 26096782
  2. Transcriptional repression mediated by the KRAB domain of the human C2H2 zinc finger protein Kox1/ZNF10 does not require histone deacetylation. Lorenz P, et al. Biol Chem, 2001 Apr. PMID 11405226
  3. The B-subdomain of the Xenopus laevis XFIN KRAB-AB domain is responsible for its weaker transcriptional repressor activity compared to human ZNF10/Kox1. Born N, et al. PLoS One, 2014. PMID 24498343, Free PMC Article
  4. The KRAB Domain of ZNF10 Guides the Identification of Specific Amino Acids That Transform the Ancestral KRAB-A-Related Domain Present in Human PRDM9 into a Canonical Modern KRAB-A Domain. Lorenz P, et al. Int J Mol Sci, 2022 Jan 19. PMID 35162997, Free PMC Article
  5. Silencing of RNA polymerases II and III-dependent transcription by the KRAB protein domain of KOX1, a Krüppel-type zinc finger factor. Moosmann P, et al. Biol Chem, 1997 Jul. PMID 9278146

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The KRAB Domain of ZNF10 Guides the Identification of Specific Amino Acids That Transform the Ancestral KRAB-A-Related Domain Present in Human PRDM9 into a Canonical Modern KRAB-A Domain.
    Title: The KRAB Domain of ZNF10 Guides the Identification of Specific Amino Acids That Transform the Ancestral KRAB-A-Related Domain Present in Human PRDM9 into a Canonical Modern KRAB-A Domain.
  2. results indicate that ZNF10 could be involved in a potent intrinsic antiretroviral defense
    Title: ZNF10 inhibits HIV-1 LTR activity through interaction with NF-κB and Sp1 binding motifs.
  3. Data indicate that Xenopus laevis XFIN-AB displayed reduced potency in repression compared to human ZNF10 KRAB-AB.
    Title: The B-subdomain of the Xenopus laevis XFIN KRAB-AB domain is responsible for its weaker transcriptional repressor activity compared to human ZNF10/Kox1.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Potential readthrough

Included gene: ZNF268

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
zinc finger protein 10
Names
zinc finger protein 10 (KOX 1)
zinc finger protein KOX1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015394.5 → NP_056209.2  zinc finger protein 10

    See identical proteins and their annotated locations for NP_056209.2

    Status: REVIEWED

    Source sequence(s)
    AC026786, AI972895, AL110188, BC024182, BE895826
    Consensus CDS
    CCDS9283.1
    UniProtKB/Swiss-Prot
    B2RBS1, P21506, Q8TC91
    Related
    ENSP00000248211.6, ENST00000248211.11
    Conserved Domains (3) summary
    smart00349
    Location:14 → 73
    KRAB; krueppel associated box
    COG5048
    Location:272 → 474
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:435 → 455
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    133130627..133159465
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    133187943..133216780
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P21506.3 GenPept UniProtKB/Swiss-Prot:P21506

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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