ZNF10 zinc finger protein 10 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ZNF10provided by HGNC
Official Full Name: zinc finger protein 10provided by HGNC
Primary source: HGNC:HGNC:12879
See related: Ensembl:ENSG00000256223 MIM:194538; AllianceGenome:HGNC:12879
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: KOX1
Summary: The protein encoded by this gene contains a C2H2 zinc finger, and has been shown to function as a transcriptional repressor. The Kruppel-associated box (KRAB) domain of this protein is found to be responsible for its transcriptional repression activity. RING finger containing protein TIF1 was reported to interact with the KRAB domain, and may serve as a mediator for the repression activity of this protein. [provided by RefSeq, Jul 2008]
Expression: Broad expression in testis (RPKM 6.7), thyroid (RPKM 5.7) and 25 other tissues See more
Orthologs: all
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Genomic context

Location:: 12q24.33

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
110	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (133130627..133159465)
110	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (133187943..133216780)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (133707213..133736051)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The KRAB Domain of ZNF10 Guides the Identification of Specific Amino Acids That Transform the Ancestral KRAB-A-Related Domain Present in Human PRDM9 into a Canonical Modern KRAB-A Domain.
Title: The KRAB Domain of ZNF10 Guides the Identification of Specific Amino Acids That Transform the Ancestral KRAB-A-Related Domain Present in Human PRDM9 into a Canonical Modern KRAB-A Domain.
results indicate that ZNF10 could be involved in a potent intrinsic antiretroviral defense
Title: ZNF10 inhibits HIV-1 LTR activity through interaction with NF-κB and Sp1 binding motifs.
Data indicate that Xenopus laevis XFIN-AB displayed reduced potency in repression compared to human ZNF10 KRAB-AB.
Title: The B-subdomain of the Xenopus laevis XFIN KRAB-AB domain is responsible for its weaker transcriptional repressor activity compared to human ZNF10/Kox1.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-H65839 (e-PCR)
- UniSTS:12623

RH81094 (e-PCR)
- UniSTS:93018

STS-R81342 (e-PCR)
- UniSTS:74884

ZNF10_7906 (e-PCR)
- UniSTS:468176

STS-R02295 (e-PCR)
- UniSTS:71130

Homology

Homologs of the ZNF10 gene: The ZNF10 gene is conserved in chimpanzee, Rhesus monkey, dog, and cow.
Orthologs from Annotation Pipeline: 138 organisms have orthologs with human gene ZNF10
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: zinc finger protein 10

Names: zinc finger protein 10 (KOX 1); zinc finger protein KOX1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_015394.5 → NP_056209.2 zinc finger protein 10

See identical proteins and their annotated locations for NP_056209.2

Status: REVIEWED

Source sequence(s)

AC026786, AI972895, AL110188, BC024182, BE895826

Consensus CDS

CCDS9283.1

UniProtKB/Swiss-Prot

P21506, Q8TC91

UniProtKB/TrEMBL

Q9UG14

Related

ENSP00000248211.6, ENST00000248211.11

Conserved Domains (3) summary

smart00349
Location:14 → 73

KRAB; krueppel associated box

COG5048
Location:272 → 474

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:435 → 455

ZF_C2H2; C2H2 Zn finger [structural motif]