Format

Send to:

Choose Destination

ZNF8 zinc finger protein 8 [ Homo sapiens (human) ]

Gene ID: 7554, updated on 4-Jul-2021

Summary

Official Symbol
ZNF8provided by HGNC
Official Full Name
zinc finger protein 8provided by HGNC
Primary source
HGNC:HGNC:13154
See related
Ensembl:ENSG00000278129 MIM:194532
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HF.18; Zfp128
Expression
Ubiquitous expression in testis (RPKM 2.9), bone marrow (RPKM 2.3) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See ZNF8 in Genome Data Viewer
Location:
19q13.43
Exon count:
4
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (58278955..58302791)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58790321..58814157)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 436 pseudogene Neighboring gene zinc finger protein 544 Neighboring gene ZNF8 divergent transcript Neighboring gene ZNF8-ERVK3-1 readthrough Neighboring gene endogenous retrovirus group K3 member 1 Neighboring gene uncharacterized LOC105372480 Neighboring gene zinc finger protein 470 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough ZNF8-ERVK3-1

Readthrough gene: ZNF8-ERVK3-1, Included gene: ERVK3-1

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding NAS
Non-traceable Author Statement
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 8
Names
zinc finger protein 272
zinc finger protein 8 (clone HF.18)
zinc finger protein HF.18

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021089.3NP_066575.2  zinc finger protein 8

    See identical proteins and their annotated locations for NP_066575.2

    Status: VALIDATED

    Source sequence(s)
    AC020915, AK093110, AK225825
    Consensus CDS
    CCDS12974.1
    UniProtKB/Swiss-Prot
    P17098
    UniProtKB/TrEMBL
    B3KS94
    Related
    ENSP00000477716.1, ENST00000621650.2
    Conserved Domains (4) summary
    smart00349
    Location:2585
    KRAB; krueppel associated box
    COG5048
    Location:167404
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:259279
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:467489
    zf-C2H2; Zinc finger, C2H2 type

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    58278955..58302791
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center