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Lyrm7 LYR motif containing 7 [ Mus musculus (house mouse) ]

Gene ID: 75530, updated on 24-Jan-2023

Summary

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Official Symbol
Lyrm7provided by MGI
Official Full Name
LYR motif containing 7provided by MGI
Primary source
MGI:MGI:1922780
See related
Ensembl:ENSMUSG00000020268 AllianceGenome:MGI:1922780
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700024C24Rik; 9330147L21Rik
Summary
Predicted to be involved in cellular respiration and mitochondrial respiratory chain complex III assembly. Located in mitochondrion. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency nuclear type 8. Orthologous to human LYRM7 (LYR motif containing 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 4.6), cortex adult (RPKM 2.1) and 18 other tissues See more
Orthologs
human all
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Genomic context

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See Lyrm7 in Genome Data Viewer
Location:
11; 11 B1.3
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (54717692..54751738, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (54826866..54860921, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene CDC42 small effector 2 Neighboring gene predicted gene 12227 Neighboring gene LYR motif containing 7, opposite strand Neighboring gene ATPase family, AAA domain containing 1 pseudogene Neighboring gene predicted gene, 31490 Neighboring gene VISTA enhancer mm1343 Neighboring gene histidine triad nucleotide binding protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
  2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (16) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein folding chaperone IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular respiration IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in cellular respiration ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial respiratory chain complex III assembly IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in mitochondrial respiratory chain complex III assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
complex III assembly factor LYRM7
Names
LYR motif-containing protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363191.2 → NP_001350120.2  complex III assembly factor LYRM7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL954817
    Conserved Domains (1) summary
    pfam05347
    Location:5 → 58
    Complex1_LYR; Complex 1 protein (LYR family)

  2. NM_029327.5 → NP_083603.4  complex III assembly factor LYRM7 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL954817
    Consensus CDS
    CCDS36154.2
    UniProtKB/Swiss-Prot
    B7ZDF8
    Related
    ENSMUSP00000120778.2, ENSMUST00000144164.9
    Conserved Domains (1) summary
    pfam05347
    Location:5 → 59
    Complex1_LYR; Complex 1 protein (LYR family)

RNA

  1. NR_156460.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL954817

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    54717692..54751738 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314815.3 → XP_017170304.1  complex III assembly factor LYRM7 isoform X1

    Conserved Domains (1) summary
    cd20267
    Location:36 → 83
    Complex1_LYR_LYRM7; LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 7 (LYRM7) and similar proteins

RNA

  1. XR_388549.2 RNA Sequence

  2. XR_388548.2 RNA Sequence

  3. XR_003949526.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DA03.2 GenPept UniProtKB/Swiss-Prot:Q9DA03

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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