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1700013H16Rik RIKEN cDNA 1700013H16 gene [ Mus musculus (house mouse) ]

Gene ID: 75514, updated on 26-Sep-2022

Summary

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Official Symbol
1700013H16Rikprovided by MGI
Official Full Name
RIKEN cDNA 1700013H16 geneprovided by MGI
Primary source
MGI:MGI:1922764
See related
Ensembl:ENSMUSG00000054727 AllianceGenome:MGI:1922764
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Slx2; Xlr6
Summary
Predicted to be involved in meiotic cell cycle and spermatogenesis, exchange of chromosomal proteins. Located in XY body; chromatin; and nucleolus. Is expressed in ovary; primary spermatocyte; and testis. Human ortholog(s) of this gene implicated in spermatogenic failure 4. Orthologous to human SYCP3 (synaptonemal complex protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 1.5) See more
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Genomic context

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See 1700013H16Rik in Genome Data Viewer
Location:
X; X A5
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (52744868..52759936, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (53742901..53757970, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene expressed sequence AW822252 Neighboring gene cancer/testis antigen 55 Neighboring gene predicted pseudogene 6025 Neighboring gene zinc finger protein 36, C3H type-like 3 Neighboring gene 60S ribosomal protein L37 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CRISPR/Cas9 Promotes Functional Study of Testis Specific X-Linked Gene In Vivo. Li M, et al. PLoS One, 2015. PMID 26599493, Free PMC Article
  2. Trim27 interacts with Slx2, is associated with meiotic processes during spermatogenesis. Zhuang XJ, et al. Cell Cycle, 2016 Oct. PMID 27612028, Free PMC Article
  3. SLX2 interacting with BLOS2 is differentially expressed during mouse oocyte meiotic maturation. Zhuang XJ, et al. Cell Cycle, 2014. PMID 24870619, Free PMC Article
  4. Characterization of a novel mouse gene encoding an SYCP3-like protein that relocalizes from the XY body to the nucleolus during prophase of male meiosis I. Tsutsumi M, et al. Biol Reprod, 2011 Jul. PMID 21451147
  5. SYCP3-like X-linked 2 is expressed in meiotic germ cells and interacts with synaptonemal complex central element protein 2 and histone acetyltransferase TIP60. Shi YQ, et al. Gene, 2013 Sep 15. PMID 23810942

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Trim27 connecting Slx2 may regulate meiotic processes in multiple ways by influencing XY body formation and germ cell proliferation during spermatogenesis.
    Title: Trim27 interacts with Slx2, is associated with meiotic processes during spermatogenesis.
  2. SLX2 might be a novel gametogenesis-related protein that could play multiple roles in regulation of meiotic processes including synaptonemal complex assembly and chromosome segregation.
    Title: SLX2 interacting with BLOS2 is differentially expressed during mouse oocyte meiotic maturation.
  3. SLX2 interacts with synaptonemal complex central element protein 2 (SYCE2), an important component of synaptonemal complex.
    Title: SYCP3-like X-linked 2 is expressed in meiotic germ cells and interacts with synaptonemal complex central element protein 2 and histone acetyltransferase TIP60.
  4. accumulates at the XY body of early pachytene to midpachytene spermatocytes
    Title: Characterization of a novel mouse gene encoding an SYCP3-like protein that relocalizes from the XY body to the nucleolus during prophase of male meiosis I.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in meiotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in spermatid development IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Component Evidence Code Pubs
located_in XY body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synaptonemal complex IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 

General protein information

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Preferred Names
synaptonemal complex protein 3-like
Names
SYCP3-like X-linked 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001200013.1 → NP_001186942.1  synaptonemal complex protein 3-like

    See identical proteins and their annotated locations for NP_001186942.1

    Status: VALIDATED

    Source sequence(s)
    AK005953, AL691513
    Consensus CDS
    CCDS53071.1
    UniProtKB/TrEMBL
    Q9DAC5
    Related
    ENSMUSP00000063474.3, ENSMUST00000067940.3
    Conserved Domains (2) summary
    pfam04803
    Location:151 → 270
    Cor1; Cor1/Xlr/Xmr conserved region
    pfam15724
    Location:4 → 69
    TMEM119; TMEM119 family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    52744868..52759936 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006535361.4 → XP_006535424.1  synaptonemal complex protein 3-like isoform X1

    Conserved Domains (1) summary
    pfam04803
    Location:11 → 142
    Cor1; Cor1/Xlr/Xmr conserved region
Nucleotide Protein Strain
Heading Accession and Version

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