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ZNF2 zinc finger protein 2 [ Homo sapiens (human) ]

Gene ID: 7549, updated on 1-Jun-2020

Summary

Official Symbol
ZNF2provided by HGNC
Official Full Name
zinc finger protein 2provided by HGNC
Primary source
HGNC:HGNC:12991
See related
Ensembl:ENSG00000275111 MIM:194500
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
A1-5; ZNF661; Zfp661
Summary
The protein encoded by this gene belongs to the C2H2-type zinc-finger protein family. The exact function of this gene is not known, however, zinc-finger proteins are known to interact with DNA and function as transcription regulators. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
Expression
Ubiquitous expression in testis (RPKM 1.8), thyroid (RPKM 1.6) and 25 other tissues See more
Orthologs

Genomic context

See ZNF2 in Genome Data Viewer
Location:
2q11.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (95165809..95184317)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (95831165..95850065)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein S5 Neighboring gene zinc finger protein 514 Neighboring gene zinc finger protein 2-like Neighboring gene solute carrier family 2 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger protein 2
Names
zinc finger protein 2.2
zinc finger protein 661

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033798.1 RefSeqGene

    Range
    5393..23901
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001017396.3NP_001017396.1  zinc finger protein 2 isoform b

    See identical proteins and their annotated locations for NP_001017396.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus than isoform a.
    Source sequence(s)
    AC092835, AI631860, AK295739, AV726545, X60152
    Consensus CDS
    CCDS42713.1
    UniProtKB/Swiss-Prot
    Q9BSG1
    UniProtKB/TrEMBL
    B0AZN8
    Related
    ENSP00000480057.1, ENST00000617923.4
    Conserved Domains (5) summary
    smart00349
    Location:132
    KRAB; krueppel associated box
    COG5048
    Location:144370
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:189209
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:299321
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:145170
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001282398.2NP_001269327.1  zinc finger protein 2 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AC092835, AI631860, AK295739, AV726545, X60152
    Consensus CDS
    CCDS62957.1
    UniProtKB/Swiss-Prot
    Q9BSG1
    UniProtKB/TrEMBL
    A0A087X063
    Related
    ENSP00000483131.1, ENST00000622059.4
    Conserved Domains (6) summary
    smart00349
    Location:1460
    KRAB; krueppel associated box
    COG5048
    Location:148374
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:193213
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:136157
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:1453
    KRAB; KRAB box
    pfam13465
    Location:149174
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001291604.2NP_001278533.1  zinc finger protein 2 isoform d

    See identical proteins and their annotated locations for NP_001278533.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two alternate exons in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (d) is shorter than isoform a.
    Source sequence(s)
    AC092835, AI631860, CR749650
    Consensus CDS
    CCDS77435.1
    UniProtKB/TrEMBL
    Q68CY6
    Related
    ENSP00000477960.1, ENST00000611463.1
    Conserved Domains (3) summary
    COG5048
    Location:106332
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:151171
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:107132
    zf-H2C2_2; Zinc-finger double domain
  4. NM_001291605.2NP_001278534.1  zinc finger protein 2 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (e) is longer than isoform a.
    Source sequence(s)
    AC092835, AI631860, AK299058, DA497792, KF459620
    Consensus CDS
    CCDS77434.1
    UniProtKB/TrEMBL
    A0A087WYR5, B4DR15
    Related
    ENSP00000482030.1, ENST00000611147.1
    Conserved Domains (6) summary
    smart00349
    Location:1474
    KRAB; krueppel associated box
    COG5048
    Location:199425
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:244264
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:187208
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:1453
    KRAB; KRAB box
    pfam13465
    Location:200225
    zf-H2C2_2; Zinc-finger double domain
  5. NM_021088.4NP_066574.2  zinc finger protein 2 isoform a

    See identical proteins and their annotated locations for NP_066574.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    AC092835, AI631860, AK295739, AV726545, BC005068
    Consensus CDS
    CCDS42712.1
    UniProtKB/Swiss-Prot
    Q9BSG1
    Related
    ENSP00000480297.1, ENST00000614034.5
    Conserved Domains (6) summary
    smart00349
    Location:1474
    KRAB; krueppel associated box
    COG5048
    Location:186412
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:231251
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:174195
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:1453
    KRAB; KRAB box
    pfam13465
    Location:187212
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    95165809..95184317
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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