Cox8c cytochrome c oxidase subunit 8C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cox8cprovided by MGI
Official Full Name: cytochrome c oxidase subunit 8Cprovided by MGI
Primary source: MGI:MGI:1922733
See related: Ensembl:ENSMUSG00000043319 AllianceGenome:MGI:1922733
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: COX8-3; COXVIII-3; 1700007F21Rik
Summary: Predicted to enable cytochrome-c oxidase activity. Located in mitochondrion. Orthologous to human COX8C (cytochrome c oxidase subunit 8C). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward testis adult (RPKM 192.7) See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 12; 12 E

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (102865565..102866793)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (102899306..102900534)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1) 1 citation

General gene information

Go to the top of the page Help

Markers

Cox8c (e-PCR), detects polymorphism
- UniSTS:546707

Homology

Orthologs from Annotation Pipeline: 88 organisms have orthologs with human gene Cox8c
Orthologs

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in mitochondrial electron transport, cytochrome c to oxygen	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
part_of mitochondrial respiratory chain complex IV	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of respiratory chain complex IV	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: cytochrome c oxidase subunit 8C, mitochondrial

Names: COX VIII-3; cytochrome c oxidase polypeptide 8; cytochrome c oxidase polypeptide VIII; cytochrome c oxidase subunit 8-3; cytochrome c oxidase subunit VIIIc

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039049.1 → NP_001034138.1 cytochrome c oxidase subunit 8C, mitochondrial

See identical proteins and their annotated locations for NP_001034138.1

Status: VALIDATED

Source sequence(s)

CF106409

Consensus CDS

CCDS56857.1

UniProtKB/Swiss-Prot

A6H666

UniProtKB/TrEMBL

A0A8C6IIK5

Related

ENSMUSP00000056155.4, ENSMUST00000053611.5

Conserved Domains (1) summary

cd00930
Location:29 → 72

Cyt_c_Oxidase_VIII; Cytochrome oxidase c subunit VIII. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...