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Cfap126 cilia and flagella associated protein 126 [ Mus musculus (house mouse) ]

Gene ID: 75472, updated on 12-May-2024

Summary

Official Symbol
Cfap126provided by MGI
Official Full Name
cilia and flagella associated protein 126provided by MGI
Primary source
MGI:MGI:1922722
See related
Ensembl:ENSMUSG00000026649 AllianceGenome:MGI:1922722
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fltp; Flattop; 1700009P17Rik
Summary
Involved in cilium organization. Located in apical plasma membrane and ciliary basal body. Is expressed in several structures, including choroid plexus; floor plate; genitourinary system; hemolymphoid system gland; and intestine. Orthologous to human CFAP126 (cilia and flagella associated protein 126). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 58.3), lung adult (RPKM 6.2) and 1 other tissue See more
Orthologs
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Genomic context

See Cfap126 in Genome Data Viewer
Location:
1 H3; 1 78.96 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (170941326..170954525)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (171113912..171126956)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3328 Neighboring gene nuclear encoded tRNA glutamic acid 6 (anticodon CTC) Neighboring gene STARR-positive B cell enhancer ABC_E2017 Neighboring gene nuclear encoded tRNA valine 6 (anticodon CAC) Neighboring gene STARR-positive B cell enhancer ABC_E222 Neighboring gene succinate dehydrogenase complex, subunit C, integral membrane protein Neighboring gene predicted gene, 46172 Neighboring gene STARR-seq mESC enhancer starr_03017 Neighboring gene STARR-positive B cell enhancer ABC_E2018 Neighboring gene myelin protein zero

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Clone Names

  • MGC74123

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell projection organization IEA
Inferred from Electronic Annotation
more info
 
involved_in cilium organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cilium organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in axonemal B tubule inner sheath IDA
Inferred from Direct Assay
more info
PubMed 
located_in axonemal microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in ciliary basal body IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
PubMed 
located_in cilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein Flattop
Names
UPF0740 protein C1orf192 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081275.2NP_001074744.1  protein Flattop isoform 1

    See identical proteins and their annotated locations for NP_001074744.1

    Status: VALIDATED

    Source sequence(s)
    AC163497
    Consensus CDS
    CCDS35771.1
    UniProtKB/Swiss-Prot
    Q6P8X9, Q9DAJ1
    UniProtKB/TrEMBL
    D3Z0N5
    Related
    ENSMUSP00000027959.5, ENSMUST00000027959.11
  2. NM_001379426.2NP_001366355.1  protein Flattop isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC163497
    UniProtKB/Swiss-Prot
    Q6P8X9, Q9DAJ1
    UniProtKB/TrEMBL
    D3Z0N5
  3. NM_001379427.1NP_001366356.1  protein Flattop isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC163497
    UniProtKB/Swiss-Prot
    Q6P8X9, Q9DAJ1
    UniProtKB/TrEMBL
    D3Z0N5
    Related
    ENSMUSP00000123188.2, ENSMUST00000151340.8
  4. NM_001410692.1NP_001397621.1  protein Flattop isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC163497
    Related
    ENSMUSP00000114967.3, ENSMUST00000129651.8
  5. NM_001410693.1NP_001397622.1  protein Flattop isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC163497

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    170941326..170954525
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011238879.4XP_011237181.1  protein Flattop isoform X3

    See identical proteins and their annotated locations for XP_011237181.1

  2. XM_036154106.1XP_036009999.1  protein Flattop isoform X2

  3. XM_011238880.3XP_011237182.1  protein Flattop isoform X3

    See identical proteins and their annotated locations for XP_011237182.1

  4. XM_006497020.2XP_006497083.1  protein Flattop isoform X1

    See identical proteins and their annotated locations for XP_006497083.1

    UniProtKB/Swiss-Prot
    Q6P8X9, Q9DAJ1
    UniProtKB/TrEMBL
    D3Z0N5
  5. XM_017312596.1XP_017168085.1  protein Flattop isoform X1

    UniProtKB/Swiss-Prot
    Q6P8X9, Q9DAJ1
    UniProtKB/TrEMBL
    D3Z0N5