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ZFX zinc finger protein X-linked [ Homo sapiens (human) ]

Gene ID: 7543, updated on 27-Dec-2018

Summary

Official Symbol
ZFXprovided by HGNC
Official Full Name
zinc finger protein X-linkedprovided by HGNC
Primary source
HGNC:HGNC:12869
See related
Ensembl:ENSG00000005889 MIM:314980
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF926
Summary
This gene on the X chromosome is structurally similar to a related gene on the Y chromosome. It encodes a member of the krueppel C2H2-type zinc-finger protein family. The full-length protein contains an acidic transcriptional activation domain (AD), a nuclear localization sequence (NLS) and a DNA binding domain (DBD) consisting of 13 C2H2-type zinc fingers. Studies in mouse embryonic and adult hematopoietic stem cells showed that this gene was required as a transcriptional regulator for self-renewal of both stem cell types, but it was dispensable for growth and differentiation of their progeny. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2010]
Expression
Ubiquitous expression in endometrium (RPKM 5.2), thyroid (RPKM 4.9) and 25 other tissues See more
Orthologs

Genomic context

See ZFX in Genome Data Viewer
Location:
Xp22.11
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) X NC_000023.11 (24148989..24216255)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (24167047..24234372)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene kelch like family member 15 Neighboring gene eukaryotic translation initiation factor 2 subunit gamma Neighboring gene ZFX antisense RNA 1 Neighboring gene SUPT20H like 2 Neighboring gene SUPT20H like 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific NAS
Non-traceable Author Statement
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
transcription coactivator activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
fertilization IEA
Inferred from Electronic Annotation
more info
 
homeostasis of number of cells IEA
Inferred from Electronic Annotation
more info
 
multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
oocyte development IEA
Inferred from Electronic Annotation
more info
 
ovarian follicle development IEA
Inferred from Electronic Annotation
more info
 
parental behavior IEA
Inferred from Electronic Annotation
more info
 
positive regulation of nucleic acid-templated transcription IEA
Inferred from Electronic Annotation
more info
 
post-embryonic development IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
zinc finger X-chromosomal protein
Names
X-linked zinc finger protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021253.2 RefSeqGene

    Range
    5001..71519
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178084.1NP_001171555.1  zinc finger X-chromosomal protein isoform 1

    See identical proteins and their annotated locations for NP_001171555.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two exons in the 5' UTR, as compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).
    Source sequence(s)
    AB209892, AC002404, DA995443, X59739
    Consensus CDS
    CCDS14211.1
    UniProtKB/Swiss-Prot
    P17010
    UniProtKB/TrEMBL
    A0A024RC04, Q59EB9
    Conserved Domains (5) summary
    COG5048
    Location:543805
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:490510
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:548570
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:70410
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:562584
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001178085.1NP_001171556.1  zinc finger X-chromosomal protein isoform 1

    See identical proteins and their annotated locations for NP_001171556.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an additional exon in the 5' UTR, as compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).
    Source sequence(s)
    AB209892, AC002404, M30608, X59740
    Consensus CDS
    CCDS14211.1
    UniProtKB/Swiss-Prot
    P17010
    UniProtKB/TrEMBL
    A0A024RC04, Q59EB9
    Related
    ENSP00000368475.1, ENST00000379177.5
    Conserved Domains (5) summary
    COG5048
    Location:543805
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:490510
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:548570
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:70410
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:562584
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001178086.1NP_001171557.1  zinc finger X-chromosomal protein isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks several exons in the 5' region, resulting in a downstream AUG start codon, as compared to variant 1. The resulting isoform (2) has a shorter N-terminus, as compared to isoform 1.
    Source sequence(s)
    AB209892, AC002404, X59738
    Consensus CDS
    CCDS55390.1
    UniProtKB/Swiss-Prot
    P17010
    UniProtKB/TrEMBL
    Q59EB9
    Related
    ENSP00000438233.1, ENST00000539115.5
    Conserved Domains (4) summary
    COG5048
    Location:314438
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:261281
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam04704
    Location:1181
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    cl19880
    Location:169216
    ROS_MUCR; ROS/MUCR transcriptional regulator protein
  4. NM_001178095.1NP_001171566.1  zinc finger X-chromosomal protein isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks two exons in the 5' UTR and has an additional segment in the 3' CDS, as compared to variant 1. The resulting isoform (3) is shorter and has a distinct C-terminus, as compared to isoform 1.
    Source sequence(s)
    AB209892, AC002404
    UniProtKB/TrEMBL
    Q59EB9
    Conserved Domains (1) summary
    pfam04704
    Location:70410
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
  5. NM_001330327.1NP_001317256.1  zinc finger X-chromosomal protein isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and includes an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (4) is longer than isoform 1.
    Source sequence(s)
    AA873535, AB209892, AC002404, BC136309, BP311445, BP374479, DA847701
    Consensus CDS
    CCDS83461.1
    UniProtKB/Swiss-Prot
    P17010
    UniProtKB/TrEMBL
    Q59EB9
  6. NM_003410.3NP_003401.2  zinc finger X-chromosomal protein isoform 1

    See identical proteins and their annotated locations for NP_003401.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) and variants 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AC002404, AF454950, DA848249, M30608
    Consensus CDS
    CCDS14211.1
    UniProtKB/Swiss-Prot
    P17010
    UniProtKB/TrEMBL
    A0A024RC04, Q8WXB7
    Related
    ENSP00000304985.5, ENST00000304543.9
    Conserved Domains (5) summary
    COG5048
    Location:543805
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:490510
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:548570
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:70410
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:562584
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p12 Primary Assembly

    Range
    24148989..24216255
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005274592.3XP_005274649.1  zinc finger X-chromosomal protein isoform X3

    See identical proteins and their annotated locations for XP_005274649.1

    UniProtKB/Swiss-Prot
    P17010
    UniProtKB/TrEMBL
    A0A024RC04
    Conserved Domains (5) summary
    COG5048
    Location:543805
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:490510
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:548570
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:70410
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:562584
    zf-H2C2_2; Zinc-finger double domain
  2. XM_017029799.1XP_016885288.1  zinc finger X-chromosomal protein isoform X6

    Conserved Domains (6) summary
    COG5048
    Location:496633
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:443463
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:672694
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:70357
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:515537
    zf-H2C2_2; Zinc-finger double domain
    cl19880
    Location:380396
    ROS_MUCR; ROS/MUCR transcriptional regulator protein
  3. XM_017029792.1XP_016885281.1  zinc finger X-chromosomal protein isoform X1

    UniProtKB/Swiss-Prot
    P17010
    Conserved Domains (5) summary
    COG5048
    Location:582719
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:529549
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:758780
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:109449
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:601623
    zf-H2C2_2; Zinc-finger double domain
  4. XM_011545581.2XP_011543883.1  zinc finger X-chromosomal protein isoform X3

    See identical proteins and their annotated locations for XP_011543883.1

    UniProtKB/Swiss-Prot
    P17010
    UniProtKB/TrEMBL
    A0A024RC04
    Conserved Domains (5) summary
    COG5048
    Location:543805
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:490510
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:548570
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:70410
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:562584
    zf-H2C2_2; Zinc-finger double domain
  5. XM_006724513.3XP_006724576.1  zinc finger X-chromosomal protein isoform X1

    See identical proteins and their annotated locations for XP_006724576.1

    UniProtKB/Swiss-Prot
    P17010
    Conserved Domains (5) summary
    COG5048
    Location:582719
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:529549
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:758780
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:109449
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:601623
    zf-H2C2_2; Zinc-finger double domain
  6. XM_017029790.1XP_016885279.1  zinc finger X-chromosomal protein isoform X1

    UniProtKB/Swiss-Prot
    P17010
    Conserved Domains (5) summary
    COG5048
    Location:582719
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:529549
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:758780
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:109449
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:601623
    zf-H2C2_2; Zinc-finger double domain
  7. XM_017029791.2XP_016885280.1  zinc finger X-chromosomal protein isoform X1

    UniProtKB/Swiss-Prot
    P17010
    Related
    ENSP00000368486.4, ENST00000379188.7
    Conserved Domains (5) summary
    COG5048
    Location:582719
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:529549
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:758780
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:109449
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:601623
    zf-H2C2_2; Zinc-finger double domain
  8. XM_017029800.2XP_016885289.1  zinc finger X-chromosomal protein isoform X7

  9. XM_017029797.2XP_016885286.1  zinc finger X-chromosomal protein isoform X5

    Conserved Domains (5) summary
    COG5048
    Location:518655
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:465485
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:694716
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:45385
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:537559
    zf-H2C2_2; Zinc-finger double domain
  10. XM_005274591.4XP_005274648.1  zinc finger X-chromosomal protein isoform X3

    See identical proteins and their annotated locations for XP_005274648.1

    UniProtKB/Swiss-Prot
    P17010
    UniProtKB/TrEMBL
    A0A024RC04
    Conserved Domains (5) summary
    COG5048
    Location:543805
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:490510
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:548570
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:70410
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:562584
    zf-H2C2_2; Zinc-finger double domain
  11. XM_017029798.2XP_016885287.1  zinc finger X-chromosomal protein isoform X5

    Conserved Domains (5) summary
    COG5048
    Location:518655
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:465485
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:694716
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:45385
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:537559
    zf-H2C2_2; Zinc-finger double domain
  12. XM_017029794.1XP_016885283.1  zinc finger X-chromosomal protein isoform X3

    UniProtKB/Swiss-Prot
    P17010
    UniProtKB/TrEMBL
    A0A024RC04
    Conserved Domains (5) summary
    COG5048
    Location:543805
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:490510
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:548570
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:70410
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:562584
    zf-H2C2_2; Zinc-finger double domain
  13. XM_017029789.1XP_016885278.1  zinc finger X-chromosomal protein isoform X1

    UniProtKB/Swiss-Prot
    P17010
    Conserved Domains (5) summary
    COG5048
    Location:582719
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:529549
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:758780
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:109449
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:601623
    zf-H2C2_2; Zinc-finger double domain
  14. XM_011545579.1XP_011543881.1  zinc finger X-chromosomal protein isoform X3

    See identical proteins and their annotated locations for XP_011543881.1

    UniProtKB/Swiss-Prot
    P17010
    UniProtKB/TrEMBL
    A0A024RC04
    Conserved Domains (5) summary
    COG5048
    Location:543805
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:490510
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:548570
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:70410
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:562584
    zf-H2C2_2; Zinc-finger double domain
  15. XM_017029788.1XP_016885277.1  zinc finger X-chromosomal protein isoform X1

    UniProtKB/Swiss-Prot
    P17010
    Conserved Domains (5) summary
    COG5048
    Location:582719
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:529549
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:758780
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:109449
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:601623
    zf-H2C2_2; Zinc-finger double domain
  16. XM_024452440.1XP_024308208.1  zinc finger X-chromosomal protein isoform X4

    Conserved Domains (5) summary
    COG5048
    Location:535672
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:482502
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:711733
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:109396
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:725749
    zf-H2C2_2; Zinc-finger double domain
  17. XM_017029793.1XP_016885282.1  zinc finger X-chromosomal protein isoform X1

    UniProtKB/Swiss-Prot
    P17010
    Conserved Domains (5) summary
    COG5048
    Location:582719
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:529549
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:758780
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:109449
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:601623
    zf-H2C2_2; Zinc-finger double domain
  18. XM_017029795.1XP_016885284.1  zinc finger X-chromosomal protein isoform X3

    UniProtKB/Swiss-Prot
    P17010
    UniProtKB/TrEMBL
    A0A024RC04
    Related
    ENSP00000343384.3, ENST00000338565.3
    Conserved Domains (5) summary
    COG5048
    Location:543805
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:490510
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:548570
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:70410
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:562584
    zf-H2C2_2; Zinc-finger double domain
  19. XM_017029796.1XP_016885285.1  zinc finger X-chromosomal protein isoform X4

    Conserved Domains (5) summary
    COG5048
    Location:535672
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:482502
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:711733
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:109396
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:725749
    zf-H2C2_2; Zinc-finger double domain
  20. XM_011545583.3XP_011543885.2  zinc finger X-chromosomal protein isoform X2

    Conserved Domains (4) summary
    COG5048
    Location:554816
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:501521
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:436458
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:81421
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
  21. XM_005274594.5XP_005274651.1  zinc finger X-chromosomal protein isoform X5

    See identical proteins and their annotated locations for XP_005274651.1

    Conserved Domains (5) summary
    COG5048
    Location:518655
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:465485
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:694716
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:45385
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:537559
    zf-H2C2_2; Zinc-finger double domain
  22. XM_017029801.1XP_016885290.1  zinc finger X-chromosomal protein isoform X8

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